Výsledky vyhledávání - "Scott Wolfrom"

Characterization of Protein Kinase C θ Activation Loop Autophosphorylation and the Kinase Domain Catalytic Mechanism

Autor: Lin Liu, Ron Kriz, Rita Greco, Mark Stahl, Karl Malakian, Divya Chaudhary, Robert M. Czerwinski, Laura Lin, Scott Wolfrom, Ann Aulabaugh, Stephane Olland, Ying Huang

Publikováno v: Biochemistry. 44:9563-9573

Protein kinase C theta (PKCtheta), a member of the Ca(2+)-independent novel subfamily of PKCs, is required for T-cell receptor (TCR) signaling and IL2 production. PKCtheta-deficient mice have impaired Th2 responses in a murine ova-induced asthma mode

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38970adad106eea6b854349f8f0ae93e
https://doi.org/10.1021/bi050608q

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Structure-Based Design of Estrogen Receptor-β Selective Ligands

Autor: Chu-Lai Hsiao, Ramesh A. Bhat, Rayomand J Unwalla, Zhang B. Xu, Karl Malakian, William S. Somers, Tatos N. Akopian, Wah-Tung Hum, Heather A. Harris, Eric S. Manas, Michael S. Malamas, Juan C. Alvarez, Ashok R. Bapat, Scott Wolfrom, Chris P. Miller, Mark Stahl

Publikováno v: Journal of the American Chemical Society. 126:15106-15119

We present the structure-based optimization of a series of estrogen receptor-beta (ERbeta) selective ligands. X-ray cocrystal structures of these ligands complexed to both ERalpha and ERbeta are described. We also discuss how molecular modeling was u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8fb882810df1e98eddbab62daae6f1a
https://doi.org/10.1021/ja047633o

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Catalytic Domain Crystal Structure of Protein Kinase C-θ (PKCθ)

Autor: Christina Benander, William S. Somers, Laura Lin, Mark Stahl, Diane Joseph-McCarthy, Karl Malakian, Rita Greco, Stephane Olland, Lori Fitz, Lidia Mosyak, Robert M. Czerwinski, Zhang-Bao Xu, Scott Wolfrom, Divya Chaudhary

Publikováno v: Journal of Biological Chemistry. 279:50401-50409

A member of the novel protein kinase C (PKC) subfamily, PKCθ, is an essential component of the T cell synapse and is required for optimal T cell activation and interleukin-2 production. Selective involvement of PKCθ in TCR signaling makes this enzy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffec59ab2a6376bd6ad4fb5f33aab08b
https://doi.org/10.1074/jbc.m409216200

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Catalytically Active MAP KAP Kinase 2 Structures in Complex with Staurosporine and ADP Reveal Differences with the Autoinhibited Enzyme

Autor: Kristine Svenson, Kevin D. Parris, Robert M. Czerwinski, Elizabeth Federico, Scott Wolfrom, Jasbir Seehra, Jean-Baptiste Telliez, William S. Somers, Michelle Maguire, Karl Malakian, Mark Stahl, Ronald W. Kriz, Kathryn W. Underwood, Chu-Lai Hsiao, Tania Shane, Lih-Ling Lin, Meggin Taylor, Yan Liu, Lidia Mosyak

Publikováno v: Structure. 11(6):627-636

MAP KAP kinase 2 (MK2), a Ser/Thr kinase, plays a crucial role in the inflammatory process. We have determined the crystal structures of a catalytically active C-terminal deletion form of human MK2, residues 41–364, in complex with staurosporine at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::097acf64f2226a080302c56bfbe63f41

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Solution structure of wild-type human matrix metalloproteinase 12 (MMP-12) in complex with a tight-binding inhibitor

Autor: Brian Dwyer, Michelle A. Markus, Karl Malakian, Scott Wolfrom, Jianchang Li, Wei Li, Désirée H. H. Tsao, James E. Wilhelm

Publikováno v: Journal of biomolecular NMR. 41(1)

MMP-12 (macrophage elastase) is a member of a family of proteases that target proteins of the extracellular matrix. Matrix metalloproteinases (MMPs) influence tissue remodeling both in healthy growth and development and in the progression of patholog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ae61de7192e2bf46ec7f558e982ca58
https://pubmed.ncbi.nlm.nih.gov/18425585

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