Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Scott Wilkie"'
Autor:
J. Scott Wilkie
Publikováno v:
Canadian Tax Journal/Revue fiscale canadienne. :615-622
Publikováno v:
Toxicology Communications. 2:81-84
Intravenous N-acetylcysteine (IV NAC) is currently the approved treatment for acetaminophen (APAP) overdose with a three-step regimen totaling 300 mg/kg over 21 hours. Due to the complexity of this...
Akademický článek
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Publikováno v:
Canadian Tax Journal/Revue fiscale canadienne. :613-614
Autor:
Jane K. Sosabowski, Sadaf Ghaem-Maghami, Lynsey M. Whilding, Jean-Pierre Jeannon, Jerome Burnet, Sjoukje J. C. van der Stegen, Stephen J. Mather, Roseanna Maria Petrovic, Ana C. Parente-Pereira, David M. Davies, Julie Foster, John Maher, Scott Wilkie
Publikováno v:
The Journal of Immunology. 191:4589-4598
The ErbB network is dysregulated in many solid tumors. To exploit this, we have developed a chimeric Ag receptor (CAR) named T1E28z that targets several pathogenetically relevant ErbB dimers. T1E28z is coexpressed with a chimeric cytokine receptor na
Autor:
Joy Burchell, Joyce Taylor-Papadimitriou, Gianfranco Picco, David M. Davies, Julie Foster, John Maher, Sefina Arif, Sylvain Julien, Scott Wilkie
Publikováno v:
Immunity. 45(5)
We read with interest the manuscript by June and colleagues published recently in Immunity in which they describe targeting of aberrantly glycosylated tumor-associated cell membrane mucin MUC1 using chimeric antigen receptor-engineered human T cells
Autor:
John Maher, S M Hobbs, May C I van Schalkwyk, Sjoukje J. C. van der Stegen, Sophie Burbridge, Carol Box, Scott Wilkie, Ana Parente Pereira, Suzanne A. Eccles, David M. Davies
Publikováno v:
Journal of Clinical Immunology. 32:1059-1070
Chimeric antigen receptor (CAR) engineered T-cells occupy an increasing niche in cancer immunotherapy. In this context, CAR-mediated CD3ζ signaling is sufficient to elicit cytotoxicity and interferon-γ production while the additional provision of C
Autor:
Vincent Kao, David M. Davies, May C I van Schalkwyk, Sjoukje J. C. van der Stegen, Zhe Liu, Ana C. Parente-Pereira, Laura Chiapero-Stanke, Carol Box, Sophie Burbridge, George J. Delinassios, Leticia Bosshard-Carter, Suzanne A. Eccles, Julie Foster, John Maher, Scott Wilkie, Stephen J. Mather
Publikováno v:
Molecular Medicine. 18:565-576
Pharmacological targeting of individual ErbB receptors elicits antitumor activity, but is frequently compromised by resistance leading to therapeutic failure. Here, we describe an immunotherapeutic approach that exploits prevalent and fundamental mec
Autor:
Joy Burchell, Joyce Taylor-Papadimitriou, John Maher, Daisy Sproviero, Scott Wilkie, Richard Beatson
Publikováno v:
Biotechnology and Bioengineering. 108:2759-2764
Chinese hamster ovary (CHO) cells are widely used for the production of recombinant proteins for clinical use as well as academic research. They are particularly important for the production of glycoproteins where bacteria cannot be used. TGFβ1 is a