Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Scott W. Mittelstadt"'
Autor:
Mohan S. Rao, Terry R. Van Vleet, Rita Ciurlionis, Wayne R. Buck, Scott W. Mittelstadt, Eric A. G. Blomme, Michael J. Liguori
Publikováno v:
Frontiers in Genetics, Vol 9 (2019)
Gene expression profiling is a useful tool to predict and interrogate mechanisms of toxicity. RNA-Seq technology has emerged as an attractive alternative to traditional microarray platforms for conducting transcriptional profiling. The objective of t
Externí odkaz:
https://doaj.org/article/8f54e5a06be041a38c8aef764788a34c
Autor:
Amanda S. Wilsey, Yevgeniya E. Koshman, Aimee L. Endemann, Sabine Sadilek, Scott W. Mittelstadt, James S. Polakowski, Brandan M. Bird, Jessica Treadway, Ruth L. Martin, Gary Gintant
Publikováno v:
Journal of pharmacological and toxicological methods. 103
Introduction The Comprehensive In Vitro Proarrhythmia Assay (CiPA) initiative differentiates torsadogenic risk of 28 drugs affecting ventricular repolarization based on multiple in vitro human derived ionic currents. However, a standardized prospecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b22faf6acdce4244a927e927e6fe257
https://pubmed.ncbi.nlm.nih.gov/32360993
https://pubmed.ncbi.nlm.nih.gov/32360993
Autor:
Bruce E. Leroy, Amanda S. Wilsey, Paige A. Ebert, Jie Lai-Zhang, Brandan M. Bird, Scott W. Mittelstadt, James S. Polakowski, Sabine Sadilek, Yevgeniya E. Koshman, Debra A. Weisbecker, C. Michael Foley
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 112:107115
Introduction This manuscript presents a successful integration of multi-timepoint biomarker blood sampling (e.g., cytokines) in a conscious dog cardiovascular study using automated blood sampling via vascular access ports in telemetry instrumented do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a1386dd3d321374a34b88a51a69c238
https://doi.org/10.1016/j.vascn.2021.107115
https://doi.org/10.1016/j.vascn.2021.107115
Autor:
Yevgeniya E. Koshman, Amanda S. Wilsey, Brandan M. Bird, Sabine Sadilek, Debra A. Weisbecker, Paige A. Ebert, Kuldip K. Mirakhur, James S. Polakowski, Gary A. Gintant, C. Michael Foley, Scott W. Mittelstadt
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 111:107003
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c45e5c67a8c524de97cc0c0a12b9ec2b
https://doi.org/10.1016/j.vascn.2021.107003
https://doi.org/10.1016/j.vascn.2021.107003
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 87:108-126
Most pharmaceutical companies test their discovery-stage proprietary molecules in a battery of in vitro pharmacology assays to try to determine off-target interactions. During all phases of drug discovery and development, various questions arise rega
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5881e7c79dd7e2fb949ecab44a5d3bd9
https://doi.org/10.1016/j.vascn.2017.02.020
https://doi.org/10.1016/j.vascn.2017.02.020
Autor:
Dustan R. Sarazan, Peter Hoffmann, Jean-Michel Guillon, Eric I. Rossman, Jennifer Doyle, Stanley T. Parish, Brian Guth, Alan Y. Chiang, John Koerner, Michael K. Pugsley, Jennifer B. Pierson, Scott W. Mittelstadt, Michael J. Engwall
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 85:1-21
Introduction The importance of drug-induced effects on the inotropic state of the heart is well known. Unlike hemodynamic and cardiac electrophysiological methods, which have been routinely used in drug safety testing for years, the non-clinical asse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b3c2f7b728d69556cae8c82df2aca66
https://doi.org/10.1016/j.vascn.2017.01.002
https://doi.org/10.1016/j.vascn.2017.01.002
Autor:
Scott W. Mittelstadt, Eric A. G. Blomme, Mufeng Hu, Srinivasa R. Mantena, Mohan S. Rao, Xin Huang, Terry R. Van Vleet, Rishi R Gupta, Michael J. Liguori
Publikováno v:
Frontiers in Big Data
Most small molecule drugs interact with unintended, often unknown, biological targets and these off-target interactions may lead to both preclinical and clinical toxic events. Undesired off-target interactions are often not detected using current dru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7ae2ac5bd03530d200ed210bd9ad037
http://europepmc.org/articles/PMC7931946
http://europepmc.org/articles/PMC7931946
Autor:
Scott W. Mittelstadt, Yevgeniya E. Koshman, Amanda S. Wilsey, Brandan M. Bird, C. Michael Foley, Paige A. Ebert, Gary Gintant, Sabine Sadilek, Debra A. Weisbecker, James S. Polakowski
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 109:107066
Introduction A successful integration of automated blood sampling (ABS) into the telemetry instrumented canine cardiovascular model is presented in this study. This combined model provides an efficient means to quickly gain understanding of potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a14693a7fd9f263998f9a4a019d9f927
https://doi.org/10.1016/j.vascn.2021.107066
https://doi.org/10.1016/j.vascn.2021.107066
Autor:
Yevgeniya E. Koshman, James S. Polakowski, Scott W. Mittelstadt, Amanda S. Wilsey, Gary A. Gintant, Brandan M. Bird
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 105:106757
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16af4ef8607279cfe6af3209f57b508b
https://doi.org/10.1016/j.vascn.2020.106757
https://doi.org/10.1016/j.vascn.2020.106757
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 101:106653
Introduction The pentylenetetrazole (PTZ)-induced seizure assay in rodents is an established method for investigating drug-induced alterations in seizure threshold such as proconvulsant effects. The standard procedure in our laboratory was to adminis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa14b5be05d4b8cc43c46367ba417712
https://doi.org/10.1016/j.vascn.2019.106653
https://doi.org/10.1016/j.vascn.2019.106653