Zobrazeno 1 - 10
of 222
pro vyhledávání: '"Scott W. Hiebert"'
Autor:
Rachel E. Brown, Justin Jacobse, Shruti A. Anant, Koral M. Blunt, Bob Chen, Paige N. Vega, Chase T. Jones, Jennifer M. Pilat, Frank Revetta, Aidan H. Gorby, Kristy R. Stengel, Yash A. Choksi, Kimmo Palin, M. Blanca Piazuelo, Mary Kay Washington, Ken S. Lau, Jeremy A. Goettel, Scott W. Hiebert, Sarah P. Short, Christopher S. Williams
Publikováno v:
JCI Insight, Vol 7, Iss 10 (2022)
Aberrant epithelial differentiation and regeneration contribute to colon pathologies, including inflammatory bowel disease (IBD) and colitis-associated cancer (CAC). Myeloid translocation gene 16 (MTG16, also known as CBFA2T3) is a transcriptional co
Externí odkaz:
https://doaj.org/article/5d314fb9ae044fb497de866e2b6326f8
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100530- (2021)
Summary: Transcriptional changes happen within minutes; however, RNAi or genetic deletion requires days to weeks before transcription networks can be analyzed. This limitation has made it challenging to distinguish direct from indirect targets of seq
Externí odkaz:
https://doaj.org/article/546831677cc14fa4bd874ec9d3d609e2
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-18 (2018)
Abstract Background Enhancers are distal cis-regulatory elements that control gene expression. Despite an increasing appreciation of the importance of enhancers in cellular function and disease, our knowledge of enhancer-regulated transcription is ve
Externí odkaz:
https://doaj.org/article/05443fe2874e4f63a3689dcfaf2da9d6
Autor:
Alessandra Ferrari, Raffaella Longo, Erika Fiorino, Rui Silva, Nico Mitro, Gaia Cermenati, Federica Gilardi, Béatrice Desvergne, Annapaola Andolfo, Cinzia Magagnotti, Donatella Caruso, Emma De Fabiani, Scott W. Hiebert, Maurizio Crestani
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Histone deacetylases, such as HDAC3, have been shown to alter cellular metabolism in various tissues. Here the authors show that HDAC3 regulates WAT metabolism by activating a futile cycle of fatty acid synthesis and oxidation, which supports WAT bro
Externí odkaz:
https://doaj.org/article/e79e6f94830242d2a35e5f6ab7dac919
Autor:
Erin R. Aho, Jing Wang, Rocco D. Gogliotti, Gregory C. Howard, Jason Phan, Pankaj Acharya, Jonathan D. Macdonald, Ken Cheng, Shelly L. Lorey, Bin Lu, Sabine Wenzel, Audra M. Foshage, Joseph Alvarado, Feng Wang, J. Grace Shaw, Bin Zhao, April M. Weissmiller, Lance R. Thomas, Christopher R. Vakoc, Matthew D. Hall, Scott W. Hiebert, Qi Liu, Shaun R. Stauffer, Stephen W. Fesik, William P. Tansey
Publikováno v:
Cell Reports, Vol 26, Iss 11, Pp 2916-2928.e13 (2019)
Summary: The chromatin-associated protein WDR5 is a promising target for pharmacological inhibition in cancer. Drug discovery efforts center on the blockade of the “WIN site” of WDR5, a well-defined pocket that is amenable to small molecule inhib
Externí odkaz:
https://doaj.org/article/624392b24e9c465daac627e90b1195e5
Autor:
Tatiana Y. Hargrove, Laura Friggeri, Zdzislaw Wawrzak, Suneethi Sivakumaran, Eugenia M. Yazlovitskaya, Scott W. Hiebert, F. Peter Guengerich, Michael R. Waterman, Galina I. Lepesheva
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 8, Pp 1552-1563 (2016)
Rapidly multiplying cancer cells synthesize greater amounts of cholesterol to build their membranes. Cholesterol-lowering drugs (statins) are currently in clinical trials for anticancer chemotherapy. However, given at higher doses, statins cause seri
Externí odkaz:
https://doaj.org/article/968e408f60a54a6ab3edc1f98e3a4e63
Autor:
Yue Zhao, Qi Liu, Pankaj Acharya, Kristy R. Stengel, Quanhu Sheng, Xiaofan Zhou, Hojoong Kwak, Melissa A. Fischer, James E. Bradner, Stephen A. Strickland, Sanjay R. Mohan, Michael R. Savona, Bryan J. Venters, Ming-Ming Zhou, John T. Lis, Scott W. Hiebert
Publikováno v:
Cell Reports, Vol 16, Iss 7, Pp 2003-2016 (2016)
Bromodomain and extra-terminal domain (BET) family inhibitors offer an approach to treating hematological malignancies. We used precision nuclear run-on transcription sequencing (PRO-seq) to create high-resolution maps of active RNA polymerases acros
Externí odkaz:
https://doaj.org/article/cf9b89b3be554977ab7d018484f46c0c
Autor:
Katerina Hatzi, Yanwen Jiang, Chuanxin Huang, Francine Garrett-Bakelman, Micah D. Gearhart, Eugenia G. Giannopoulou, Paul Zumbo, Kevin Kirouac, Srividya Bhaskara, Jose M. Polo, Matthias Kormaksson, Alexander D. MacKerell, Jr., Fengtian Xue, Christopher E. Mason, Scott W. Hiebert, Gilbert G. Prive, Leandro Cerchietti, Vivian J. Bardwell, Olivier Elemento, Ari Melnick
Publikováno v:
Cell Reports, Vol 4, Iss 3, Pp 578-588 (2013)
The BCL6 transcriptional repressor is required for the development of germinal center (GC) B cells and diffuse large B cell lymphomas (DLBCLs). Although BCL6 can recruit multiple corepressors, its transcriptional repression mechanism of action in nor
Externí odkaz:
https://doaj.org/article/9cd7d9fe59494c7fbf2a87fbc864e290
Autor:
Ari M. Melnick, Hans-Guido Wendel, Olivier Elemento, Wayne Tam, Randy D. Gascoyne, Scott W. Hiebert, Rita Shaknovich, Robert G. Roeder, Chi-Shuen Chu, James W. Young, Sneh Sharma, Edward Holson, Janice E. Kranz, Kristy R. Stengel, David W. Scott, Daisuke Ennishi, Shenqiu Wang, David Poloway, Zhuoning Li, Cem Meydan, Matt Teater, Xabier Agirre, Ashley S. Doane, Ling Wang, Dylan McNally, Sara Parsa, Katerina Hatzi, Hsia-Yuan Ying, Huimin Geng, Ana Ortega-Molina, Yanwen Jiang
Supplementary Figure S1. Crebbp deficiency results in accelerated germinal center derived B-cell lymphoma development in mice. Supplementary Figure S2. Ep300 deficiency results in accelerated germinal center derived B-cell lymphoma development in mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::454b834f82e2ea2602f9d0f040226cbc
https://doi.org/10.1158/2159-8290.22531458.v1
https://doi.org/10.1158/2159-8290.22531458.v1
Autor:
Ari M. Melnick, Hans-Guido Wendel, Olivier Elemento, Wayne Tam, Randy D. Gascoyne, Scott W. Hiebert, Rita Shaknovich, Robert G. Roeder, Chi-Shuen Chu, James W. Young, Sneh Sharma, Edward Holson, Janice E. Kranz, Kristy R. Stengel, David W. Scott, Daisuke Ennishi, Shenqiu Wang, David Poloway, Zhuoning Li, Cem Meydan, Matt Teater, Xabier Agirre, Ashley S. Doane, Ling Wang, Dylan McNally, Sara Parsa, Katerina Hatzi, Hsia-Yuan Ying, Huimin Geng, Ana Ortega-Molina, Yanwen Jiang
A list of CREBBP mutations in cohorts 1 and 2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::170541a36aea2225266b7c0ac1cd81df
https://doi.org/10.1158/2159-8290.22531446
https://doi.org/10.1158/2159-8290.22531446