Výsledky vyhledávání - "Scott W. Harden"

Akademický článek

Topographical mapping of catecholaminergic axon innervation in the flat-mounts of the mouse atria: a quantitative analysis

Autor: Yuanyuan Zhang, Ariege Bizanti, Scott W. Harden, Jin Chen, Kohlton Bendowski, Donald B. Hoover, David Gozal, Kalyanam Shivkumar, Maci Heal, Susan Tappan, Zixi Jack Cheng

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-21 (2023)

Abstract The sympathetic nervous system is crucial for controlling multiple cardiac functions. However, a comprehensive, detailed neuroanatomical map of the sympathetic innervation of the heart is unavailable. Here, we used a combination of state-of-

Externí odkaz: https://doaj.org/article/e340f3bc4a02456abe92439c9d8f290f

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Akademický článek

A rapid in vitro assay for evaluating the effects of acetylcholinesterase inhibitors and reactivators in the rat basolateral amygdala

Autor: Jeffrey S. Thinschmidt, Scott W. Harden, Michael A. King, James D. Talton, Charles J. Frazier

Publikováno v: Frontiers in Cellular Neuroscience, Vol 16 (2022)

We established a novel brain slice assay to test the ability of acetylcholinesterase (AChE) reactivators to prevent ACh-induced M1 muscarinic acetylcholine receptor (mAChR) dependent hyperexcitability observed after exposure to the organophosphate (O

Externí odkaz: https://doaj.org/article/3545c7d60f87475388b0638bb2d7565a

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Akademický článek

A Novel Organ-Specific Approach to Selectively Target Sensory Afferents Innervating the Aortic Arch

Autor: Khalid Elsaafien, Scott W. Harden, Dominique N. Johnson, Aecha K. Kimball, Wanhui Sheng, Justin A. Smith, Karen A. Scott, Charles J. Frazier, Annette D. de Kloet, Eric G. Krause

Publikováno v: Frontiers in Physiology, Vol 13 (2022)

The brain maintains cardiovascular homeostasis, in part, via the arterial baroreflex which senses changes in blood pressure (BP) at the level of the aortic arch. Sensory afferents innervating the aortic arch employ baroreceptors to convert stretch ex

Externí odkaz: https://doaj.org/article/0d05e03e04494f7ea60e27dbb7215a69

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Catecholaminergic axon innervation and morphology in flat‐mounts of atria and ventricles of mice

Autor: Ariege Bizanti, Yuanyuan Zhang, Scott W. Harden, Jin Chen, Donald B. Hoover, David Gozal, Kalyanam Shivkumar, Zixi Jack Cheng

Publikováno v: Journal of Comparative Neurology. 531:596-617

Sympathetic efferent axons regulate cardiac functions. However, the topographical distribution and morphology of cardiac sympathetic efferent axons remain insufficiently characterized due to the technical challenges involved in immunohistochemical la

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd40b23cb92b09419da7bfa04ced97b2
https://doi.org/10.1002/cne.25444

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Cover Image, Volume 531, Issue 5

Autor: Ariege Bizanti, Yuanyuan Zhang, Scott W. Harden, Jin Chen, Donald B. Hoover, David Gozal, Kalyanam Shivkumar, Zixi Jack Cheng

Publikováno v: Journal of Comparative Neurology. 531

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e33b3ea2bda52b01ccbb8732982f60a8
https://doi.org/10.1002/cne.25464

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A rapid

Autor: Jeffrey S, Thinschmidt, Scott W, Harden, Michael A, King, James D, Talton, Charles J, Frazier

Publikováno v: Frontiers in cellular neuroscience. 16

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a0c0019a3170b82e68bdf4e2747f9678
https://pubmed.ncbi.nlm.nih.gov/36479275

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Abstract 060: Angiotensin Type-2 Receptors In The Median Preoptic Nucleus Demarcate A Novel Depressor Neural Circuit In Mice

Autor: Khalid Elsaafien, Sophia A Eikenberry, Scott W Harden, Wanhui Sheng, Karen A Scott, Charles J Frazier, Colin Sumners, Eric G Krause, Annette D De Kloet

Publikováno v: Hypertension. 79

Blood pressure (BP) is under constant control and regulation by an extensive neural network that spans a number of brain regions. This includes the median preoptic nucleus (MnPO) which directly projects to the pre-autonomic neurons of the hypothalamu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::53ac4d49d70a6473ffbc523e74bd70ab
https://doi.org/10.1161/hyp.79.suppl_1.060

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Targeting angiotensin type-2 receptors located on pressor neurons in the nucleus of the solitary tract to relieve hypertension in mice

Autor: Eliot A. Spector, Dominique Johnson, U. Muscha Steckelings, Wanhui Sheng, Michael Bader, Khalid Elsaafien, Colin Sumners, Scott W Harden, Charles J. Frazier, Lei Wang, Mazher Mohammed, Eric G. Krause, Karen A. Scott, Annette D. de Kloet

Publikováno v: Cardiovasc Res
Mohammed, M, Johnson, D N, Wang, L A, Harden, S W, Sheng, W, Spector, E A, Elsaafien, K, Bader, M, Steckelings, U M, Scott, K A, Frazier, C J, Sumners, C, Krause, E G & de Kloet, A D 2022, ' Targeting angiotensin type-2 receptors located on pressor neurons in the nucleus of the solitary tract to relieve hypertension in mice ', Cardiovascular Research, vol. 118, no. 3, pp. 883-896 . https://doi.org/10.1093/cvr/cvab085

Aims These studies evaluate whether angiotensin type-2 receptors (AT2Rs) that are expressed on γ-aminobutyric acid (GABA) neurons in the nucleus of the solitary tract (NTS) represent a novel endogenous blood pressure lowering mechanism. Methods and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01aac8c2f28e2d59aaf124a742553095
https://doi.org/10.1093/cvr/cvab085

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