Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Scott W Simpkins"'
Autor:
Scott W Simpkins, Justin Nelson, Raamesh Deshpande, Sheena C Li, Jeff S Piotrowski, Erin H Wilson, Abraham A Gebre, Hamid Safizadeh, Reika Okamoto, Mami Yoshimura, Michael Costanzo, Yoko Yashiroda, Yoshikazu Ohya, Hiroyuki Osada, Minoru Yoshida, Charles Boone, Chad L Myers
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 10, p e1006532 (2018)
Chemical-genetic interactions-observed when the treatment of mutant cells with chemical compounds reveals unexpected phenotypes-contain rich functional information linking compounds to their cellular modes of action. To systematically identify these
Externí odkaz:
https://doaj.org/article/cc4b7ae2190a401d93c6e05659c6a94d
Autor:
Mami Yoshimura, Yoko Yashiroda, Hiroyuki Osada, Scott W. Simpkins, Chad L. Myers, Minoru Yoshida, Jeff S. Piotrowski, Charles Boone, Hamid Safizadeh, Justin Nelson, Sheena C. Li, Hiroyuki Hirano
Publikováno v:
Journal of Chemical Information and Modeling
A common strategy for identifying molecules likely to possess a desired biological activity is to search large databases of compounds for high structural similarity to a query molecule that demonstrates this activity, under the assumption that struct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4b1d0ca1e81c28f13234dc1c9ee7a28
https://doi.org/10.1021/acs.jcim.0c00993
https://doi.org/10.1021/acs.jcim.0c00993
Autor:
Amy Li, Jose A. Seoane, Peter K. Jackson, Micah Olivas, Scott W. Simpkins, Grace R. Anderson, Michael C. Bassik, Kaja Kostyrko, Marcus R. Kelly, Christina Curtis, Monte M. Winslow, Andrew J. Gentles, David Yao, Michael M. Dubreuil, Calvin J. Kuo, Keonil Lee, Michael Wainberg, Kaitlyn Spees, Maryam Yousefi, Anshul Kundaje, Kyuho Han, Alejandro Sweet-Cordero, Sarah E. Pierce, Yuan-Hung Lo, Roarke A. Kamber
Publikováno v:
Nature
Cancer genomics studies have identified thousands of putative cancer driver genes1. Development of high-throughput and accurate models to define the functions of these genes is a major challenge. Here we devised a scalable cancer-spheroid model and p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::814a0e6c24f49fbae32a463f81172744
http://europepmc.org/articles/PMC7368463
http://europepmc.org/articles/PMC7368463
Autor:
Fauna Yarza, Duke Hong, Yi Zhang, James Boocock, Scott W. Simpkins, Nathan B. Lubock, Leonid Kruglyak, Bianca Judy Choe, Aaron R. Cooper, Molly Gasperini, Manish J. Butte, Isabella Lin, Valerie A. Arboleda, Laila Sathe, Nathan LaPierre, Jonathan Flint, Oliver F. Brandenberg, Evann E. Hilt, Robert Damoiseaux, Jimin Park, Sukantha Chandrasekaran, Lior Pachter, Eric T. Jones, Tre Quan Love, Sriram Kosuri, Mark Lucas, Dawn Marquette, Clifford Kravit, Gabriel Oland, Stephania Kay, Kyle M. Kovary, A. Sina Booeshaghi, Chongyuan Luo, Joshua S. Bloom, Longhua Guo, Erin M. Thompson, Yi Yin, Omai B. Garner, Myles Hochman, Eleazar Eskin, Chetan Munugala
Publikováno v:
medRxiv
article-version (status) pre
article-version (number) 2
article-version (status) pre
article-version (number) 2
The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is due to the high rates of transmission by individuals who are asymptomatic at the time of transmission1,2. Frequent, widespread testing of the asymptomatic population
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fbd40c7106e112bb4624cbb4d11fee3
https://resolver.caltech.edu/CaltechAUTHORS:20201119-132151980
https://resolver.caltech.edu/CaltechAUTHORS:20201119-132151980
Autor:
Charles Boone, Henry N. Ward, Minoru Yoshida, Scott W. Simpkins, Hiroyuki Osada, Justin Nelson, Sheena C. Li, Yoko Yashiroda, Jeff S. Piotrowski, Chad L. Myers, Raamesh Deshpande
Publikováno v:
Nature Protocols. 14:415-440
The construction of genome-wide mutant collections has enabled high-throughput, high-dimensional quantitative characterization of gene and chemical function, particularly via genetic and chemical–genetic interaction experiments. As the throughput o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90822d6a0564d445e2aa6a0ba0f68c65
https://doi.org/10.1038/s41596-018-0099-1
https://doi.org/10.1038/s41596-018-0099-1
Autor:
Laura Luebbert, Scott W. Simpkins, Nathan B. Lubock, A. Sina Booeshaghi, Aaron R. Cooper, Joshua S. Bloom, Sriram Kosuri, Jase Gehring, Lior Pachter
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-7 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-7 (2020)
Scalable, inexpensive, and secure testing for SARS-CoV-2 infection is crucial for control of the novel coronavirus pandemic. Recently developed highly multiplexed sequencing assays (HMSAs) that rely on high-throughput sequencing can, in principle, me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad40dedc3a57805f317688687c7eb74a
Autor:
Nathan LaPierre, Chongyuan Luo, Sukantha Chandrasekaran, Sriram Kosuri, Erin M. Thompson, Gabriel Oland, Mark Lucas, Chetan Munugala, Duke Hong, Manish J. Butte, Scott W. Simpkins, Jonathan Flint, Isabella Lin, Lior Pachter, Omai B. Garner, Stephania Kay, James Boocock, Molly Gasperini, Leonid Kruglyak, Bianca Judy Choe, Laila Sathe, Robert Damoiseaux, A. Sina Booeshaghi, Yi Yin, Longhua Guo, Kyle M. Kovary, Myles Hochman, Eleazar Eskin, Valerie A. Arboleda, Joshua S. Bloom, Nathan B. Lubock, Yi Zhang, Dawn Marquette, Fauna Yarza, Eric T. Jones, Clifford Kravit, Aaron R. Cooper, TreQuan Love, Oliver F. Brandenberg, Evann E. Hilt, Jimin Park
Publikováno v:
medRxiv, vol 1, iss 09-09
Author(s): Bloom, Joshua; Sathe, Laila; Munugala, Chetan; Jones, Eric; Gasperini, Molly; Lubock, Nathan; Yarza, Fauna; Thompson, Erin; Kovary, Kyle; Park, Jimin; Marquette, Dawn; Kay, Stephania; Lucas, Mark; Love, TreQuan; Booeshaghi, Sina; Brandenbe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::568a99d2399dab4da00c6569c91d4d46
Autor:
Scott W. Simpkins, Nathan B. Lubock, A. Sina Booeshaghi, Laura Luebbert, Jase Gehring, Aaron R. Cooper, Lior Pachter, Sriram Kosuri, Joshua S. Bloom
Scalable, inexpensive, accurate, and secure testing for SARS-CoV-2 infection is crucial for control of the novel coronavirus pandemic. Recently developed highly multiplexed sequencing assays that rely on high-throughput sequencing (HMSAs) can, in pri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c5902b2039923360d202996ef65de6d
Autor:
Scott W. Simpkins, Fan Zhang, Marc G. Chevrette, Lingjun Li, Scott R. Rajski, Cameron R. Currie, Christopher J. Thompson, Srikar N. Adibhatla, Doug R. Braun, Bradon R. McDonald, Justin Nelson, Tim S. Bugni, Navid Adnani, Qing Yu, Chad L. Myers, Jeff S. Piotrowski
Publikováno v:
ACS Chemical Biology. 12:3093-3102
Advances in genomics and metabolomics have made clear in recent years that microbial biosynthetic capacities on Earth far exceed previous expectations. This is attributable, in part, to the realization that most microbial natural product (NP) produce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97e8bff6632ff08602c60eb94bfc3440
https://doi.org/10.1021/acschembio.7b00688
https://doi.org/10.1021/acschembio.7b00688
Autor:
Yao yue Fan, Minoru Yoshida, Jin biao Xu, Yue Zhu, Fu lai Zhou, Scott W. Simpkins, Justin Nelson, Sheena C. Li, Yoko Yashiroda, Wan jing Guo, Li jun Shao, Qing Liu, Ming-Wei Wang, Charles Boone, Jian min Yue, Tian Xia, Chad L. Myers, De hua Yang
Publikováno v:
Acta Pharmacologica Sinica
Chemical genomics has been applied extensively to evaluate small molecules that modulate biological processes in Saccharomyces cerevisiae. Here, we use yeast as a surrogate system for studying compounds that are active against metazoan targets. Large
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abdf603c5dd6447fee4abc46a3e547f0
https://pubmed.ncbi.nlm.nih.gov/32081979
https://pubmed.ncbi.nlm.nih.gov/32081979