Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Scott W Rogers"'
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0175367 (2017)
Nicotine modulates multiple inflammatory responses in the lung through the nicotinic acetylcholine receptor subtype alpha7 (α7). Previously we reported that α7 modulates both the hematopoietic and epithelium responses in the lung to the bacterial i
Externí odkaz:
https://doaj.org/article/6184f33eb6f34ec1bbc690dc3c8a6092
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0187773 (2017)
Cigarette smoking (CS) is a principal contributor to a spectrum of devastating lung diseases whose occurrence and severity may vary between individuals and not appear for decades after prolonged use. One explanation for the variability and delay in d
Externí odkaz:
https://doaj.org/article/b0fc045f62d24e86b4f4c7e7116b8bf0
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0123218 (2015)
The IfitmDel mouse lacks all five of the Ifitm genes via LoxP deletion. This animal breeds normally with no obvious defect in development. The IfitmDel animals exhibit a steady and significantly enhanced weight gain relative to wild-type controls beg
Externí odkaz:
https://doaj.org/article/7395adf61e844165ac1bae2b274981aa
Autor:
Scott W Rogers, Lorise C Gahring
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0143319 (2015)
High affinity nicotine-binding sites in the mammalian brain are neuronal nicotinic acetylcholine receptors (nAChR) assembled from at least alpha4 and beta2 subunits into pentameric ion channels. When exposed to ligands such as nicotine, these recepto
Externí odkaz:
https://doaj.org/article/a111ee530f354f1a808bf9e2a6b71e80
Autor:
Elena Y Enioutina, Elizabeth J Myers, Petr Tvrdik, John R Hoidal, Scott W Rogers, Lorise C Gahring
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0121128 (2015)
The nicotinic acetylcholine receptor alpha7 (α7) is expressed by neuronal and non-neuronal cells throughout the body. We examined the mechanisms of the lung inflammatory response to intranasal (i.n.) lipopolysaccharide (LPS) regulated by α7. This w
Externí odkaz:
https://doaj.org/article/1da234aa146a450c8b6f7638010dd6e6
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e103861 (2014)
The nicotinic acetylcholine receptor alpha 7 (α7) is a ligand-activated ion channel that contributes to a diversity of cellular processes involved in development, neurotransmission and inflammation. In this report the expression of α7 was examined
Externí odkaz:
https://doaj.org/article/e50c9027dcc64dd7a3701ff766588e81
Autor:
Lorise C Gahring, Elena Y Enioutina, Elizabeth J Myers, Gerald J Spangrude, Olga V Efimova, Todd W Kelley, Petr Tvrdik, Mario R Capecchi, Scott W Rogers
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e57481 (2013)
How inflammatory responses are mechanistically modulated by nicotinic acetylcholine receptors (nAChR), especially by receptors composed of alpha7 (α7) subunits, is poorly defined. This includes a precise definition of cells that express α7 and how
Externí odkaz:
https://doaj.org/article/d1ef7d8b58034a3d89f3176649d9eed0
Autor:
Scott W Rogers, Lorise C Gahring
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e36467 (2012)
The expression of nicotinic acetylcholine receptor (nAChR) subtype, alpha7, was investigated in the developing teeth of mice that were modified through homologous recombination to express a bi-cistronic IRES-driven tau-enhanced green fluorescent prot
Externí odkaz:
https://doaj.org/article/df3f155645c046529576f520feb65049
Autor:
Robert B Weiss, Timothy B Baker, Dale S Cannon, Andrew von Niederhausern, Diane M Dunn, Nori Matsunami, Nanda A Singh, Lisa Baird, Hilary Coon, William M McMahon, Megan E Piper, Michael C Fiore, Mary Beth Scholand, John E Connett, Richard E Kanner, Lorise C Gahring, Scott W Rogers, John R Hoidal, Mark F Leppert
Publikováno v:
PLoS Genetics, Vol 4, Iss 7, p e1000125 (2008)
People who begin daily smoking at an early age are at greater risk of long-term nicotine addiction. We tested the hypothesis that associations between nicotinic acetylcholine receptor (nAChR) genetic variants and nicotine dependence assessed in adult
Externí odkaz:
https://doaj.org/article/967db3d79cd44178b104b1f07b91bd4b
Autor:
Andrew N. Freedman, Elizabeth M. Gillanders, Kelly K. Filipski, Scott W. Rogers, Tram Kim Lam, Damali N. Martin, Stefanie A. Nelson, Rolando Barajas, Melissa Rotunno, Danielle Daee, Lisa Gallicchio, Rao L. Divi, Mukesh Verma, Danielle M. Carrick, Sarah Fagan
Publikováno v:
Cancer Epidemiol Biomarkers Prev
Background: The goals of this project were to assess the status of NCI's rare cancer–focused population science research managed by the Division of Cancer Control and Population Sciences (DCCPS), to develop a framework for evaluation of rare cancer