Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Scott W Morrical"'
Autor:
Carolyn G Marsden, Ryan B Jensen, Jennifer Zagelbaum, Eli Rothenberg, Scott W Morrical, Susan S Wallace, Joann B Sweasy
Publikováno v:
PLoS Genetics, Vol 12, Iss 8, p e1006208 (2016)
The RAD51 protein plays a key role in the homology-directed repair of DNA double-strand breaks and is important for maintaining genome stability. Here we report on a novel human RAD51 variant found in an aggressive and therapy-refractive breast carci
Externí odkaz:
https://doaj.org/article/862a410adb6e4d8390160c03ec59b5dd
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e112656 (2014)
Isothermal nucleic acid amplification technologies offer significant advantages over polymerase chain reaction (PCR) in that they do not require thermal cycling or sophisticated laboratory equipment. However, non-target-dependent amplification has li
Externí odkaz:
https://doaj.org/article/6edd7e693c7f453baa6352f6d07cf8cf
Autor:
Robyn L Maher, Scott W Morrical
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66654 (2013)
Homologous recombination is important for the error-free repair of DNA double-strand breaks and for replication fork restart. Recombinases of the RecA/Rad51 family perform the central catalytic role in this process. UvsX recombinase is the RecA/Rad51
Externí odkaz:
https://doaj.org/article/86782b6137814ef4ae22b846769f5ea9
Autor:
Adrian P Wiegmans, Ambber Ward, Ekaterina Ivanova, Pascal H G Duijf, Mark N Adams, Idris Mohd Najib, Romy Van Oosterhout, Martin C Sadowski, Greg Kelly, Scott W Morrical, Ken O’Byrne, Jason S Lee, Derek J Richard
Publikováno v:
NAR Cancer
Autor:
Ambber Ward, Mark N. Adams, Romy Van Oosterhout, Idris Mohd Najib, Derek J. Richard, Pascal H.G. Duijf, Ekaterina Ivanova, Kenneth J. O'Byrne, Jason Sang Hun Lee, Scott W. Morrical, Martin C. Sadowski, Adrian P. Wiegmans, Greg Kelly
Publikováno v:
NAR Cancer
Wiegmans, Adrian P; Ward, Ambber; Ivanova, Ekaterina; Duijf, Pascal H G; Adams, Mark N; Najib, Idris Mohd; Van Oosterhout, Romy; Sadowski, Martin C; Kelly, Greg; Morrical, Scott W; O'Byrne, Ken; Lee, Jason S; Richard, Derek J (2021). Genome instability and pressure on non-homologous end joining drives chemotherapy resistance via a DNA repair crisis switch in triple negative breast cancer. NAR cancer, 3(2), zcab022. Oxford University Press 10.1093/narcan/zcab022
Wiegmans, Adrian P; Ward, Ambber; Ivanova, Ekaterina; Duijf, Pascal H G; Adams, Mark N; Najib, Idris Mohd; Van Oosterhout, Romy; Sadowski, Martin C; Kelly, Greg; Morrical, Scott W; O'Byrne, Ken; Lee, Jason S; Richard, Derek J (2021). Genome instability and pressure on non-homologous end joining drives chemotherapy resistance via a DNA repair crisis switch in triple negative breast cancer. NAR cancer, 3(2), zcab022. Oxford University Press 10.1093/narcan/zcab022
Chemotherapy is used as a standard-of-care against cancers that display high levels of inherent genome instability. Chemotherapy induces DNA damage and intensifies pressure on the DNA repair pathways that can lead to deregulation. There is an urgent
Autor:
Michelle C. Silva, Adrian P. Wiegmans, April M. Averill, Julie A. Dragon, Scott W. Morrical, Katie E. Bryan, Milagros D. Morrical
Publikováno v:
DNA repair. 60
The human RAD51 recombinase possesses DNA pairing and strand exchange activities that are essential for the error-free, homology-directed repair of DNA double-strand breaks. The recombination activities of RAD51 are activated upon its assembly into p
Autor:
Ryan B. Jensen, Eli Rothenberg, Carolyn G. Marsden, Jennifer Zagelbaum, Joann B. Sweasy, Susan S. Wallace, Scott W. Morrical
Publikováno v:
PLoS Genetics, Vol 12, Iss 8, p e1006208 (2016)
PLoS Genetics
PLoS Genetics
The RAD51 protein plays a key role in the homology-directed repair of DNA double-strand breaks and is important for maintaining genome stability. Here we report on a novel human RAD51 variant found in an aggressive and therapy-refractive breast carci
Autor:
Milagros D. Morrical, Katie E. Bryan, Julie A. Dragon, Scott W. Morrical, April M. Averill, Michelle C. Silva, Jeffrey P. Bond
In human cells, error-free repair of DNA double-strand breaks requires the DNA pairing and strand exchange activities of RAD51 recombinase. Activation of RAD51 recombination activities requires the assembly of RAD51 presynaptic filaments on the singl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7f6d3c47caec2ef7f093e3dfeba2026
https://europepmc.org/articles/PMC4884548/
https://europepmc.org/articles/PMC4884548/
Publikováno v:
Journal of Cellular Biochemistry. 112:2672-2682
Across the evolutionary spectrum, living organisms depend on high-fidelity DNA replication and recombination mechanisms to maintain genome stability and thus to avoid mutation and disease. The repair of severe lesions in the DNA such as double-strand
Publikováno v:
Nucleic Acids Research
To carry out homologous recombination events in the cell, recombination proteins must be able to recognize and form presynaptic filaments on single-stranded DNA (ssDNA) in the presence of a vast excess of double-stranded DNA (dsDNA). Therefore recomb