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pro vyhledávání: '"Scott VandePol"'
Autor:
Scott VandePol, John J. Holland
Publikováno v:
Journal of General Virology. 67:441-451
Summary BHK-21 cells readily produce tumours in athymic nude mice, but BHK-21 cells persistently infected with wild-type vesicular stomatitis virus (VSV) do not. However, rare persistently infected virus-shedding tumours (VSV-P tumour cells) were ind
Autor:
Scott VandePol, Cecilio López-Galíndez, Juan Ortín, Pilar Pérez-Breña, Esteban Domingo, Rafael Nájera, Agustín Portela, John J. Holland, David A. Steinhauer, Juan Carlos de la Torre, Francisco Sobrino, Nieves Villanueva, Encarnación Martínez-Salas, Nicholas J. Depolo
Publikováno v:
Scopus-Elsevier
We review evidence that cloned (or uncloned) populations of most RNA viruses do not consist of a single genome species of defined sequence, but rather of heterogeneous mixtures of related genomes (quasispecies). Due to very high mutation rates, genom
Publikováno v:
Virology. 148(2)
A panel of neutralizing and nonneutralizing monoclonal antibodies (MAbs) to the Indiana strain of vesicular stomatitis virus (VSV-IND) were used to select nonbinding VSV-IND mutants. In addition, virus was passaged against high titered polyclonal ant
Autor:
Frank M. Horodyski, Katherine R. Spindler, John J. Holland, Stuart T. Nichol, Elizabeth A. Grabau, Scott VandePol
Publikováno v:
Science (New York, N.Y.). 215(4540)
RNA viruses show high mutation frequencies partly because of a lack of the proofreading enzymes that assure fidelity of DNA replication. This high mutation frequency is coupled with high rates of replication reflected in rates of RNA genome evolution