Safety of rAAV2/2-ND4 Gene Therapy for Leber Hereditary Optic Neuropathy

Autor: Nitza Thomasson, Serge Fitoussi, Sandrine Meunier, Jean-François Girmens, Barrett Katz, Bernard Gilly, Anne Galy, José-Alain Sahel, Samuel Bidot, Jean Philippe Combal, Sonia Valero, Laure Blouin, Céline Bouquet, Scott Uretsky, Catherine Vignal

Publikováno v: Ophthalmology: Journal of The American Academy of Ophthalmology
Ophthalmology: Journal of The American Academy of Ophthalmology, 2018, 125 (6), pp.945-947. ⟨10.1016/j.ophtha.2017.12.036⟩

International audience; No abstract available

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e9584754d64e8fcb64cf7a424575550
https://www.hal.inserm.fr/inserm-03721131

83. Relationship Between Immune Responses and Ocular Inflammation: What Is Learnt from Intravitreal Injection of rAAV2-2-ND4 (GS010) in Non-Human Primates and Leber Hereditary Optic Neuropathy (LHON) Patients

Autor: Céline Bouquet, Anne Galy, Catherine Vignal, Nitza Thomasson, Serge Fitoussi, Jean-Philippe Combal, Scott Uretsky, José Sahel, Roxane Noel, Sandrine Meunier

Publikováno v: Molecular Therapy. 24:S36-S37

GenSight Biologics develops a rAAV2/2-ND4 vector (GS010) administered via intravitreal route (IVI) against vision loss in LHON patients bearing ND4 mutation. Gene therapy Adeno Associated Viral vectors are known to trigger host immune response which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8bf1a8003eab5a453a087bfe748ed678
https://doi.org/10.1016/s1525-0016(16)32892-1

Nitrogen bisphosphonate-induced orbital inflammatory disease: gamma delta T cells--a report and review of 2 cases

Autor: Scott Uretsky, I Rand Rodgers, Monisha M. Vora

Publikováno v: Ophthalmic plastic and reconstructive surgery. 30(4)

With the increased use of nitrogen bisphosphonate therapy for osteoporosis, multiple myeloma, metastatic prostate carcinoma, and Paget disease, it is now recognized that orbital inflammation is a potential sequelae of treatment. To date, 15 isolated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c071e44e0487d0f22a0e73e81ef7bcbe
https://pubmed.ncbi.nlm.nih.gov/24814269

Visual field deficits

Autor: Scott Uretsky

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aebe17906704aff3acd5dbd44eb46b13
https://doi.org/10.1017/cbo9781139028899.079

Black as night

Autor: Teri T. Kleinberg, Ann P. Murchison, Jurij R. Bilyk, Adam E. Flanders, Scott Uretsky

Publikováno v: Survey of ophthalmology. 60(3)

A 30-year-old man presented with painless total visual loss in the right eye. Fundus exam and imaging was consistent with total internal carotid artery occlusion and hemispheric stroke. The presentation and management options of retinal vascular occl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c2e13486cf9e844d20986a3d6af630e
https://pubmed.ncbi.nlm.nih.gov/25311430