Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Scott Thacher"'
Publikováno v:
Journal of the Endocrine Society. 6:A894-A895
Background Adrenocortical cancer (ACC) is a rare endocrine malignancy frequently diagnosed at an advanced stage when prognosis is dismal. Mitotane, the only approved therapy for locally advanced or metastatic disease, is minimally effective, and rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93ec6ab252a0ac577132f07d5933e43c
https://doi.org/10.1210/jendso/bvac150.1853
https://doi.org/10.1210/jendso/bvac150.1853
Autor:
Masayuki Kotoku, Makoto Shiozaki, Akihiro Nomura, Takayuki Yamaguchi, Scott Thacher, Haiyan Tao, Paul Crowe, Satoki Doi, Keishi Yamaguchi, Shintaro Hirashima, Katsuya Maeda, Masato Noguchi, Tsuyoshi Adachi, Yoshiaki Katsuda, Kazuyuki Hirata
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
Scientific Reports
Scientific Reports
Retinoic acid-related orphan receptor gamma (RORγ) plays pivotal roles in autoimmune diseases by controlling the lineage of interleukin 17 (IL-17)-producing CD4+ T cells (Th17 cells). Structure-based drug design has proven fruitful in the developmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd8a3773ea748399c2e67ba680c3af4f
http://link.springer.com/article/10.1038/s41598-018-35783-9
http://link.springer.com/article/10.1038/s41598-018-35783-9
Autor:
Yoshiaki Katsuda, Erin Bradley, Masato Noguchi, Masafumi Kamada, Kazuyuki Hirata, Haiyan Tao, Xioalin Li, Paul Crowe, Bruno Tse, Masayuki Kotoku, Akihiro Nomura, Ken Murase, Tsuyoshi Adachi, Ruo Steensma, Takayuki Yamaguchi, Makoto Shiozaki, Keishi Yamaguchi, Morgan Fenn, Scott Thacher, Satoki Doi, Shintaro Hirashima, Robert Babine
Publikováno v:
Genes to cells : devoted to molecularcellular mechanisms. 22(6)
Retinoid-related orphan receptor gamma (RORγ) directly controls the differentiation of Th17 cell and the production of interleukin-17, which plays an integral role in autoimmune diseases. To obtain insight into RORγ, we have determined the first cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a5d2c9cb5064cdd4916b16d8cf238cb
https://pubmed.ncbi.nlm.nih.gov/28493531
https://pubmed.ncbi.nlm.nih.gov/28493531
Autor:
Naoki Miyagawa, Kota Asahina, Shintaro Hirashima, Scott Thacher, Satoki Doi, Masayuki Kotoku, Yukihiro Nomura, Katsuya Maeda, Shingo Obika, Haiyan Tao, Erin Bradley, Yoshiaki Katsuda, Paul Crowe, Seki Noriyoshi, Ruo Steensma, Takahiro Hata, Tsuyoshi Adachi, Robert Babine, Sakai Takayuki, Makoto Shiozaki, Kojo Arita, Masato Noguchi, Takaki Maeba, Xiaolin Li, Yasunori Hase, Morgan Fenn, Kazuyuki Hirata, Masafumi Kamada, Yusuke Aratsu, Akimi Hori, Takayuki Yamaguchi, Hiromasa Hashimoto
A novel series of RORγ inhibitors was identified starting with the HTS hit 1. After SAR investigation based on a prospective consideration of two drug-likeness metrics, ligand efficiency (LE) and fraction of sp(3) carbon atoms (Fsp(3)), significant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a980bfa040ac0bdac6e9c6c9a5fd8c0
https://europepmc.org/articles/PMC4716592/
https://europepmc.org/articles/PMC4716592/
Autor:
Michael D. Cameron, Juliana J. Conkright, Gina M. Zastrow, Peter Hodder, Xiaolin Li, Patrick R. Griffin, Franck Madoux, Scott Thacher, Peter Chase
Publikováno v:
Molecular pharmacology. 73(6)
The steroidogenic factor 1 (SF-1, also known as NR5A1) is a transcription factor belonging to the nuclear receptor superfamily. Whereas most of the members of this family have been extensively characterized, the therapeutic potential and pharmacology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d5fa8fd4970c27b7d71c8afd0b7ec21
https://pubmed.ncbi.nlm.nih.gov/18334597
https://pubmed.ncbi.nlm.nih.gov/18334597
Autor:
Bob, Park, Scott, Thacher
Publikováno v:
Science for the people. 9(5)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b61393d49e45258987875fcbc4ce61c7
https://pubmed.ncbi.nlm.nih.gov/11662396
https://pubmed.ncbi.nlm.nih.gov/11662396