Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Scott Tanghe"'
Autor:
Frederick Annang, Guiomar Pérez-Moreno, Caridad Díaz, Victor González-Menéndez, Nuria de Pedro Montejo, José Pérez del Palacio, Paula Sánchez, Scott Tanghe, Ana Rodriguez, Ignacio Pérez-Victoria, Juan Cantizani, Luis M. Ruiz-Pérez, Olga Genilloud, Fernando Reyes, Francisca Vicente, Dolores González-Pacanowska
Publikováno v:
Malaria Journal, Vol 20, Iss 1, Pp 1-10 (2021)
Abstract Background Malaria is a global health problem for which novel therapeutic compounds are needed. To this end, a recently published novel family of antiplasmodial macrolides, strasseriolides A–D, was herein subjected to in vivo efficacy stud
Externí odkaz:
https://doaj.org/article/19452ec86bc944d3bca7f97ac48433c7
Autor:
Pollyanna Stephanie Gomes, Scott Tanghe, Julio Gallego-Delgado, Luciana Conde, Leonardo Freire-de-Lima, Ana Carolina Lima, Célio Geraldo Freire-de-Lima, Josué da Costa Lima Junior, Otacílio Moreira, Paulo Totino, Ana Rodriguez, Adriane Regina Todeschini, Alexandre Morrot
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
Cerebral malaria (CM) is a clinical syndrome involving irreversible and lethal signs of brain injury associated to infection by parasites of the genus Plasmodium. The pathogenesis of CM derives from infection-induced proinflammatory cytokines associa
Externí odkaz:
https://doaj.org/article/e2b23a236a7c48a8977cca5596783d2e
Autor:
Lori Ferrins, Amrita Sharma, Sarah M Thomas, Naimee Mehta, Jessey Erath, Scott Tanghe, Susan E Leed, Ana Rodriguez, Kojo Mensa-Wilmot, Richard J Sciotti, Kirsten Gillingwater, Michael P Pollastri
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 12, Iss 11, p e0006834 (2018)
We recently reported the medicinal chemistry re-optimization of a series of compounds derived from the human tyrosine kinase inhibitor, lapatinib, for activity against Plasmodium falciparum. From this same library of compounds, we now report potent c
Externí odkaz:
https://doaj.org/article/7cdba245bb1545f0a3fa0706ebb2f1b2
Autor:
Kimberly G. Brady, Richard J. Sciotti, Mitchell F. Gallerstein, Jessey Erath, Jennifer L. Woodring, Kelly A. Bachovchin, Ana Rodriguez, Susan E. Leed, Kojo Mensa-Wilmot, Scott Tanghe, Michael P. Pollastri
Publikováno v:
European Journal of Medicinal Chemistry. 141:446-459
Human African trypanosomiasis (HAT) is a deadly disease in need of new chemotherapeutics that can cross into the central nervous system. We previously reported the discovery of 2 (NEU-617), a small molecule with activity against T. brucei bloodstream
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80ac3197a1f70ef8d9d7ab13e0674a32
https://doi.org/10.1016/j.ejmech.2017.10.007
https://doi.org/10.1016/j.ejmech.2017.10.007
Autor:
Ana Rodriguez, Scott Tanghe, Ralf Erdmann, Marcel Kaiser, Marta Kolonko, Wolfgang Schliebs, Leonidas Emmanouilidis, Konstantinos Tripsianes, Pascal Mäser, Michael Sattler, Grzegorz M Popowicz, Kenji Schorpp, Vishal C. Kalel, Maciej Dawidowski, Kamyar Hadian
Publikováno v:
Science. 355:1416-1420
The parasitic protists of the Trypanosoma genus infect humans and domestic mammals, causing severe mortality and huge economic losses. The most threatening trypanosomiasis is Chagas disease, affecting up to 12 million people in the Americas. We repor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5675f4f56831663488b7ad7c244e75c8
https://doi.org/10.1126/science.aal1807
https://doi.org/10.1126/science.aal1807
Autor:
Leonardo Freire-de-Lima, Julio Gallego-Delgado, Luciana Conde, Scott Tanghe, Paulo Renato Rivas Totino, Adriane R. Todeschini, Josué da Costa Lima Junior, Ana Rodriguez, Alexandre Morrot, Ana Carolina Bastos de Lima, Pollyanna Stephanie Gomes, Celio Geraldo Freire-de-Lima, Otacilio C. Moreira
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
Cerebral malaria (CM) is a clinical syndrome involving irreversible and lethal signs of brain injury associated to infection by parasites of the genus Plasmodium. The pathogenesis of CM derives from infection-induced proinflammatory cytokines associa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::491d482515a6e63c766e114ef3afdc38
https://doi.org/10.3389/fmicb.2019.00305
https://doi.org/10.3389/fmicb.2019.00305
Autor:
Dana M. Klug, Richard J. Sciotti, Baljinder Singh, Seema Bag, Kojo Mensa-Wilmot, Jeremiah D. Momper, Hitesh B. Jalani, Ana Rodriguez, Melissa J. Buskes, Kelly A. Bachovchin, Katherine M. Schneider, Michael P. Pollastri, Scott Tanghe, Lori Ferrins, Amrita Sharma, Naimee Mehta
Publikováno v:
Journal of medicinal chemistry, vol 62, iss 2
Lapatinib, an approved epidermal growth factor receptor inhibitor, was explored as a starting point for the synthesis of new hits against Trypanosoma brucei, the causative agent of human African trypanosomiasis (HAT). Previous work culminated in 1 (N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b9d04f11b4d25eb3432d3d37479f934
https://escholarship.org/uc/item/0qv0q4v1
https://escholarship.org/uc/item/0qv0q4v1
Autor:
Ana Rodriguez, Scott Tanghe, Mason S. Deinema, Kay Perry, Timothy A. Roy, Hanna S. Gracz, Edward L. D'Antonio, Jennifer D’Antonio, Tyler A. Frey, Sean P. Kearns
Publikováno v:
Molecular and Biochemical Parasitology. 204:64-76
Glucokinase and hexokinase from pathogenic protozoa Trypanosoma cruzi are potential drug targets for antiparasitic chemotherapy of Chagas’ disease. These glucose kinases phosphorylate D-glucose with co-substrate ATP and yields glucose 6-phosphate a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3f1b9e9a38f715aee70d8c250151069
https://doi.org/10.1016/j.molbiopara.2015.12.004
https://doi.org/10.1016/j.molbiopara.2015.12.004
Autor:
Pollyanna Stephanie, Gomes, Scott, Tanghe, Julio, Gallego-Delgado, Luciana, Conde, Leonardo, Freire-de-Lima, Ana Carolina, Lima, Célio Geraldo, Freire-de-Lima, Josué da Costa, Lima Junior, Otacílio, Moreira, Paulo, Totino, Ana, Rodriguez, Adriane Regina, Todeschini, Alexandre, Morrot
Publikováno v:
Frontiers in Microbiology
Cerebral malaria (CM) is a clinical syndrome involving irreversible and lethal signs of brain injury associated to infection by parasites of the genus Plasmodium. The pathogenesis of CM derives from infection-induced proinflammatory cytokines associa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0861453bd3ec675fc286cc6abcb3fc86
https://pubmed.ncbi.nlm.nih.gov/30873136
https://pubmed.ncbi.nlm.nih.gov/30873136
Autor:
Richard J. Sciotti, Sarah M. Thomas, Lori Ferrins, Amrita Sharma, Michael P. Pollastri, Kirsten Gillingwater, Jessey Erath, Scott Tanghe, Kojo Mensa-Wilmot, Ana Rodriguez, Naimee Mehta, Susan E. Leed
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 12, Iss 11, p e0006834 (2018)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases
We recently reported the medicinal chemistry re-optimization of a series of compounds derived from the human tyrosine kinase inhibitor, lapatinib, for activity against Plasmodium falciparum. From this same library of compounds, we now report potent c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a7126b42a80f5f9bcadfbd89f67c822
https://edoc.unibas.ch/67069/
https://edoc.unibas.ch/67069/