Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Scott Struthers"'
Autor:
Jian Zhao, Shimiao Wang, Stacy Markison, Sun Hee Kim, Sangdon Han, Mi Chen, Ana Karin Kusnetzow, Elizabeth Rico-Bautista, Michael Johns, Rosa Luo, R. Scott Struthers, Ajay Madan, Yunfei Zhu, Stephen F. Betz
Publikováno v:
ACS Medicinal Chemistry Letters. 14:66-74
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a11c0a55f0670850cd8a44d1e01d93a
https://doi.org/10.1021/acsmedchemlett.2c00431
https://doi.org/10.1021/acsmedchemlett.2c00431
Autor:
Monica R Gadelha, Murray B Gordon, Mirjana Doknic, Emese Mezősi, Miklós Tóth, Harpal Randeva, Tonya Marmon, Theresa Jochelson, Rosa Luo, Michael Monahan, Ajay Madan, Christine Ferrara-Cook, R Scott Struthers, Alan Krasner
Publikováno v:
The Journal of clinical endocrinology and metabolism.
Context Paltusotine is a once-daily, oral, nonpeptide small-molecule somatostatin receptor type 2 (SST2) agonist in clinical development for treatment of acromegaly. Objective This work aimed to evaluate change in insulin-like growth factor I (IGF-I)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be9d7b46a2bde5060b0a9b5ef4c5a48b
https://pubmed.ncbi.nlm.nih.gov/36582134
https://pubmed.ncbi.nlm.nih.gov/36582134
Autor:
Zhao, Jian, Wang, Shimiao, Hee Kim, Sun, Han, Sangdon, Rico-Bautista, Elizabeth, Sturchler, Emmanuel, Nguyen, Julie, Tan, Hannah, Staley, Christine, Karin Kusnetzow, Ana, Betz, Stephen F., Johns, Michael, Goulet, Lance, Luo, Rosa, Fowler, Melissa, Athanacio, Jon, Markison, Stacy, Scott Struthers, R., Zhu, Yunfei
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 1 September 2022 71
Autor:
Christine Ferrara-Cook, Rosa Luo, Eduardo De La Torre, Yang Wang, Stephen Betz, Ajay Madan, Scott Struthers, Ulrike Hövelmann, Tim Heise, Alan Krasner
Publikováno v:
Journal of the Endocrine Society. 6:A408-A409
Congenital hyperinsulinism (HI) is the most common cause of persistent hypoglycemia in neonates, infants, and children, and is caused by genetic mutations in the insulin secretion pathway in pancreatic beta-cells. Current medical and surgical treatme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4adb17055f1a66b7dd175fc55840b5a4
https://doi.org/10.1210/jendso/bvac150.850
https://doi.org/10.1210/jendso/bvac150.850
Autor:
Monica R Gadelha, Harpal Randeva, Murray B Gordon, Emese Mezosi, Mirjana Doknic, Miklos Toth, Cesar L Boguszewski, Melissa Nichols, Theresa Jochelson, Scott Henley, Meenal Patel, Debbie Koh Mendez, Christine Ferrara-Cook, Alan Krasner, Alessandra Casagrande, R Scott Struthers
Publikováno v:
Endocrine Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3b1d7d1957436406076d6a51cd12b1d
https://doi.org/10.1530/endoabs.81.oc4.6
https://doi.org/10.1530/endoabs.81.oc4.6
Autor:
Jian Zhao, Shimiao Wang, Sun Hee Kim, Sangdon Han, Elizabeth Rico-Bautista, Emmanuel Sturchler, Julie Nguyen, Hannah Tan, Christine Staley, Ana Karin Kusnetzow, Stephen F. Betz, Michael Johns, Lance Goulet, Rosa Luo, Melissa Fowler, Jon Athanacio, Stacy Markison, R. Scott Struthers, Yunfei Zhu
Publikováno v:
Bioorganicmedicinal chemistry letters. 71
SST5 receptor activation potently inhibits insulin secretion from pancreatic β-cells, and an orally available nonpeptide selective SST5 agonist may be used to effectively manage the blood glucose levels of congenital HI patients to avoid severe hypo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08412728bd9e34f60beabf7d56a84d5c
https://pubmed.ncbi.nlm.nih.gov/35605837
https://pubmed.ncbi.nlm.nih.gov/35605837
Autor:
Ajay Madan, Stacy Markison, Stephen F. Betz, Alan Krasner, Rosa Luo, Theresa Jochelson, Jason Lickliter, R. Scott Struthers
Publikováno v:
Pituitary. 25(2)
Purpose Evaluate the pharmacodynamics, pharmacokinetics, and safety of paltusotine, an orally bioavailable, nonpeptide, somatostatin receptor subtype 2 (SST2) agonist being developed for the treatment of acromegaly and neuroendocrine tumors. Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b20574ba53c22e9b6dc20890c869cb90
https://pubmed.ncbi.nlm.nih.gov/35000098
https://pubmed.ncbi.nlm.nih.gov/35000098
Autor:
Stephen Betz, Christine Ferrara-Cook, Martha Hernandez-Illas, Rosa Luo, Ajay Madan, Stephanie Miller, Scott Struthers, Peter Trainer, Yang Wang, Alan Krasner
Publikováno v:
Journal of the Endocrine Society. 6:A83-A83
CRN04894 is a potent orally bioavailable MC2R (adrenal cortex specific ACTH receptor) antagonist (Kb=0.34 nM) that is >1000-fold selective for MC2R over other melanocortin receptor subtypes. In rats receiving continuous administration of ACTH via sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31eae219dd4a68cbc115f07b370d6e6a
https://doi.org/10.1210/jendso/bvac150.172
https://doi.org/10.1210/jendso/bvac150.172
Autor:
Rosa Luo, Mirjana Doknic, Mônica R. Gadelha, Harpal S. Randeva, Miklos Toth, Tonya Marmon, Alan Krasner, Ajay Madan, Murray B. Gordon, Michael Monahan, Scott Struthers, Emese Mezosi
Publikováno v:
Endocrine Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e28ad3e78de30b03af6fb4f10430e2f1
https://doi.org/10.1530/endoabs.73.oc15.4
https://doi.org/10.1530/endoabs.73.oc15.4
Autor:
Zhao, Jian, Wang, Shimiao, Han, Sangdon, Kim, Sun Hee, Kusnetzow, Ana Karin, Nguyen, Julie, Rico-Bautista, Elizabeth, Tan, Hannah, Betz, Stephen F., Scott Struthers, R., Zhu, Yunfei
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 1 September 2020 30(17)