Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Scott Simanski"'
Publikováno v:
Cell Reports, Vol 16, Iss 6, Pp 1733-1748 (2016)
Post-translational modification can modulate protein conformation and alter binding partner recruitment within gene regulatory regions. Here, we report that bromodomain-containing protein 4 (BRD4), a transcription co-factor and chromatin regulator, u
Externí odkaz:
https://doaj.org/article/3b8b5ad868b341e3a27fe0cc7fc5ccef
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:2773-2778
One bead one compound (OBOC) libraries can be screened against serum samples to identify ligands to antibodies in this mixture. In this protocol, hit beads are identified by staining with a fluorescent labeled secondary antibody. When screens are con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0a9a706b1eae11e7c75536d04611a22
https://doi.org/10.1016/j.bmcl.2018.01.033
https://doi.org/10.1016/j.bmcl.2018.01.033
Publikováno v:
npj Parkinson's Disease, Vol 4, Iss 1, Pp 1-5 (2018)
NPJ Parkinson's Disease
NPJ Parkinson's Disease
Parkinson disease (PD) is a progressive neurodegenerative disease with motor symptoms that result from degeneration of midbrain dopaminergic neurons. Biomarker research seeks to identify the disease during the pre-symptomatic phase, which is a time w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be0499f2349536aec308a10c0dcf3181
http://link.springer.com/article/10.1038/s41531-018-0064-2
http://link.springer.com/article/10.1038/s41531-018-0064-2
Publikováno v:
Cell Cycle. 16:940-946
Cellular transitions are achieved by the concerted actions of regulated degradation pathways. In the case of the cell cycle, ubiquitin mediated degradation ensures unidirectional transition from one phase to another. For instance, turnover of the cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1c276b7f2adf337cd4b42c25340585c
https://doi.org/10.1080/15384101.2017.1301333
https://doi.org/10.1080/15384101.2017.1301333
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1861:892-899
Background The proteasome catalyzes the degradation of many mis-folded proteins, which are otherwise cytotoxic. There is interest in the discovery of proteasome agonists, but previous efforts to do so have been disappointing. Methods The cleavage of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cb2599eb8fa81f9f35ddc65cd84e512
https://doi.org/10.1016/j.bbagen.2017.01.003
https://doi.org/10.1016/j.bbagen.2017.01.003
Publikováno v:
Cell Reports, Vol 16, Iss 6, Pp 1733-1748 (2016)
Post-translational modification can modulate protein conformation and alter binding partner recruitment within promoter regulatory regions. Here, we find that bromodomain-containing protein 4 (BRD4), a transcription cofactor and chromatin regulator,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::322b1ce13d3cf47ebe193d19bb60780d
http://www.sciencedirect.com/science/article/pii/S2211124716308877
http://www.sciencedirect.com/science/article/pii/S2211124716308877
Publikováno v:
Cell Chem Biol
Summary We previously reported a peptoid ligand for the proteasomal ubiquitin receptor Rpn13 called KDT-11 and demonstrated that this compound is toxic to multiple myeloma cells, but not non-malignant cells. Here, we show that KDT-11 decreases the vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d69c43ab152ebef6818b74806ac8e8c1
https://doi.org/10.1016/j.chembiol.2020.08.008
https://doi.org/10.1016/j.chembiol.2020.08.008
Autor:
Junichiro Takaya, Daniel Abegg, Ekaterina V. Vinogradova, Benjamin F. Cravatt, Alexander Adibekian, Hongchan An, Paige Dickson, Thomas Kodadek, Scott Simanski
Publikováno v:
Cell Chem Biol
Summary Rpn13 is one of several ubiquitin receptors in the 26S proteasome. Cys88 of Rpn13 has been proposed to be the principal target of RA190, an electrophilic small molecule with interesting anti-cancer activities. Here, we examine the claim that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::296fc0431d007c5f615176897678b0bf
https://doi.org/10.1016/j.chembiol.2020.08.007
https://doi.org/10.1016/j.chembiol.2020.08.007
Inhibitory Activity of The Chloroform Extract of Ficus benjamina Leaf on Multiple Myeloma Cell lines
Publikováno v:
The FASEB Journal. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42bdc3e4671da2920c1b3a1802a89f8c
https://doi.org/10.1096/fasebj.2018.32.1_supplement.804.39
https://doi.org/10.1096/fasebj.2018.32.1_supplement.804.39
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:4910-4917
'Antigen surrogates' are synthetic, non-natural molecules that recognize the antigen-binding sites of antibodies. These molecules are of interest as replacements for native antigens as antibody 'capture agents' in ELISA-like assays of potential diagn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8a63d221f9e1c0a3490c83950557ab7
https://doi.org/10.1016/j.bmcl.2015.05.046
https://doi.org/10.1016/j.bmcl.2015.05.046