Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Scott S. Woodard"'
Autor:
Huey-Sheng Shieh, Grace E. Munie, Nicole Caspers, Alfredo G. Tomasselli, James R. Kiefer, Karl J. Mathis, Arthur J. Wittwer, Micky D. Tortorella, Scott S. Woodard, Mark E. Schnute, Jennifer M. Williams, Anne-Marie Malfait
Publikováno v:
Protein Science. 20:735-744
A ((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl) succinamide derivative (here referred to as Compound 12) shows significant activity toward many matrix metalloproteinases (MMPs), including MMP-2, MMP-8, MMP-9, and MMP-13. Modeling studies had predicte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7956cccbf2929ee94ea4a421918afe33
https://doi.org/10.1002/pro.606
https://doi.org/10.1002/pro.606
Autor:
Kevin D. Jerome, Scott S. Woodard
Publikováno v:
Combinatorial Chemistry & High Throughput Screening. 14:132-137
Combinatorial cyclizations of imidates and hydrazides with methylene linked R groups, generated from the corresponding nitriles and carboxylic acids, respectively, provided a large library of 3,5-dimethylene substituted 1,2,4-trizoles. [formula: see
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6c15a99da6268495dc561c61c45df9d
https://doi.org/10.2174/138620711794474033
https://doi.org/10.2174/138620711794474033
Autor:
Kaliappan Iyanar, Jessica D. Dietz, Graciela B. Arhancet, Horng-Chih Huang, Danny J. Garland, Marcia I. Heron, Silvia I. Pomposiello, Xiao Hu, Len F. Lee, Joe T. Collins, Scott S. Woodard, James Robert Blinn, Maria A. Payne, Brenda L. Case, Rhonda S. Woerndle
Publikováno v:
Journal of Medicinal Chemistry. 53:5970-5978
A new 1,4-dihydropyridine 5a, containing a cyano group at the C3 position, was recently reported to possess excellent mineralocorticoid receptor (MR) antagonist in vitro potency and no calcium channel-blocker (CCB) activity. In the present study, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9288e4053ed7e7f775bce265c4ec3184
https://doi.org/10.1021/jm100506y
https://doi.org/10.1021/jm100506y
Autor:
Grace M. Wagner, Joe T. Collins, Scott S. Woodard, Randal E Numann, Kaliappan Iyanar, Graciela B. Arhancet, Danny J. Garland, James Robert Blinn, Jessica D. Dietz, Horng-Chih Huang, Xiao Hu
Publikováno v:
Journal of Medicinal Chemistry. 53:4300-4304
A number of known 1,4-dihydropyridine CCBs were identified as having comparable potency to the steroidal MR antagonist eplerenone. Chiral resolution of mebudipine revealed that MR and CCB activity reside in opposite enantiomers. Small molecule X-ray
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6e7af97f6c33d3bb740cfc75d288cac
https://doi.org/10.1021/jm1002827
https://doi.org/10.1021/jm1002827
Publikováno v:
Bulletin of the Chemical Society of Japan. 69:3601-3605
Most secondary alcohols and β,γ-unsaturated primary alcohols have been catalytically oxidized with N-chloro-4-chlorobenzenesulfonamide sodium salt to the corresponding carbonyl compounds by the addition of a 0.01—0.03 molar amount of dimethyl 2,2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3313044ba592a077be5c2668fddc787c
https://doi.org/10.1246/bcsj.69.3601
https://doi.org/10.1246/bcsj.69.3601
Publikováno v:
ChemInform. 28
Most secondary alcohols and β,γ-unsaturated primary alcohols have been catalytically oxidized with N-chloro-4-chlorobenzenesulfonamide sodium salt to the corresponding carbonyl compounds by the addition of a 0.01—0.03 molar amount of dimethyl 2,2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7ec2bd49f137a0bd995730269007bfd
https://doi.org/10.1002/chin.199716077
https://doi.org/10.1002/chin.199716077
Autor:
Sumathy Mathialagan, Jill Chrencik, Scott S. Woodard, Nandini Kishore, Julia A. Guzova, Robin A. Weinberg, Shaun R. Selness, Eric T. Baima, Gabriel Mbalaviele, John F. Schindler, Sheri L. Bonar, Lily R.-H. Song, Medora M. Hardy, William F. Hood, Eva E. Nagiec
Publikováno v:
The Journal of Biological Chemistry
The classical nuclear factor kappaB (NF-kappaB) signaling pathway is under the control of the IkappaB kinase (IKK) complex, which consists of IKK-1, IKK-2, and NF-kappaB essential modulator (NEMO). This complex is responsible for the regulation of ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0554c30fdfc058636a2f89f8139d732c
https://pubmed.ncbi.nlm.nih.gov/20167598
https://pubmed.ncbi.nlm.nih.gov/20167598
Autor:
Grace E. Munie, Nicole Caspers, Alfredo G. Tomasselli, Karl J. Mathis, Jennifer M. Williams, Mark E. Schnute, Anne-Marie Malfait, Arthur J. Wittwer, Micky D. Tortorella, Scott S. Woodard, Huey-Sheng Shieh
Publikováno v:
The Journal of biological chemistry. 284(36)
Several inhibitors of a series of cis-1(S)2(R)-amino-2-indanol-based compounds were reported to be selective for the aggrecanases, ADAMTS-4 and -5 over other metalloproteases. To understand the nature of this selectivity for aggrecanases, the inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71d0a2eb43e69ba44b9b16749d11329b
https://pubmed.ncbi.nlm.nih.gov/19586907
https://pubmed.ncbi.nlm.nih.gov/19586907
Publikováno v:
Journal of the American Chemical Society. 113:106-113
The rate of titanium-tartrate-catalyzed asymmetric epoxidation of allylic alcohols is shown to be first order in substrate and oxidant, and inverse second order in inhibitor alcohol, under pseudo-first-order conditions in catalyst. The rate is slowed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::feca190e5f0d9af56167cee4c203c807
https://doi.org/10.1021/ja00001a018
https://doi.org/10.1021/ja00001a018
Autor:
John P. Chupp, John M. Molyneaux, Gina L. Stikes, Y. Larry Sing, Len F. Lee, Scott S. Woodard
Publikováno v:
The Journal of Organic Chemistry. 55:2872-2877
A series of 2-(trifluoromethyl)-1,4- and -3,4-dihydro-3,5-pyridinedicarboxylates 5a-y and 6a-y undergo an unprecedented dehydrofluorination upon treatment with 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU), trialkylamines, or 2,6-lutidine to give the corr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a003799e7b84eeb39799120d27619524
https://doi.org/10.1021/jo00296a058
https://doi.org/10.1021/jo00296a058