HBD-3 induces NK cell activation, IFN-γ secretion and mDC dependent cytolytic function

Autor: Chelsey J. Judge, Elane Reyes-Aviles, Aaron Weinberg, Sara J. Conry, Donald D. Anthony, Zhimin Feng, Scott S. Sieg

Publikováno v: Cellular Immunology. 297:61-68

We previously showed that human beta defensin-3 (hBD-3) activates mDC via TLR1/2. Here we investigated the effects of hBD-3 on NK cell activation state and effector functions. We observed that hBD-3 activates PBMC to secrete IFN-γ and kill K562 and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0e8ab197c446c0772db3ce00ac135be
https://doi.org/10.1016/j.cellimm.2015.06.004

Viral and host mediators of non-suppressible HIV-1 viremia.

Autor: Mohammadi A; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Valley Health System, Las Vegas, NV, USA., Etemad B; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Zhang X; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Beijing Friendship Hospital Pinggu Campus, Capital Medical University, Beijing, China., Li Y; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; University of Pittsburgh, Pittsburgh, PA, USA., Bedwell GJ; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Sharaf R; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Kittilson A; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Melberg M; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Crain CR; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA., Traunbauer AK; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Wong C; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Fajnzylber J; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Worrall DP; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA., Rosenthal A; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Jordan H; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Jilg N; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Kaseke C; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA., Giguel F; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Lian X; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA., Deo R; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Gillespie E; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Chishti R; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Abrha S; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Adams T; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Siagian A; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Dorazio D; Division of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University/University Hospitals Cleveland Medical Center, Cleveland, OH, USA., Anderson PL; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Deeks SG; Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, CA, USA., Lederman MM; Division of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University/University Hospitals Cleveland Medical Center, Cleveland, OH, USA., Yawetz S; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Kuritzkes DR; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Lichterfeld MD; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA., Sieg S; Division of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University/University Hospitals Cleveland Medical Center, Cleveland, OH, USA., Tsibris A; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Carrington M; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.; Basic Science Program, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, MD, USA.; Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA., Brumme ZL; Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada., Castillo-Mancilla JR; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.; Division of Infectious Diseases, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Engelman AN; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Gaiha GD; Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA., Li JZ; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. jli@bwh.harvard.edu.

Publikováno v: Nature medicine [Nat Med] 2023 Dec; Vol. 29 (12), pp. 3212-3223. Date of Electronic Publication: 2023 Nov 13.

Human β defensin-3 induces chemokines from monocytes and macrophages: diminished activity in cells from HIV-infected persons.

Autor: Petrov V; Department of Biological Sciences, Case School of Dental Medicine, Case Western Reserve University, Cleveland, OH, USA., Funderburg N, Weinberg A, Sieg S

Publikováno v: Immunology [Immunology] 2013 Dec; Vol. 140 (4), pp. 413-20.

The yin and yang of human Beta-defensins in health and disease.

Autor: Weinberg A; Department of Biological Sciences, Case Western Reserve University School of Dental Medicine Cleveland, OH, USA., Jin G, Sieg S, McCormick TS

Publikováno v: Frontiers in immunology [Front Immunol] 2012 Oct 08; Vol. 3, pp. 294. Date of Electronic Publication: 2012 Oct 08 (Print Publication: 2012).

Predictive value of plasma HIV RNA level on rate of CD4 T-cell decline in untreated HIV infection.

Autor: Rodríguez B; Center for AIDS Research, Case Western Reserve University, Cleveland, Ohio, USA. rodriguez.benigno@clevelandactu.org, Sethi AK, Cheruvu VK, Mackay W, Bosch RJ, Kitahata M, Boswell SL, Mathews WC, Bangsberg DR, Martin J, Whalen CC, Sieg S, Yadavalli S, Deeks SG, Lederman MM

Publikováno v: JAMA [JAMA] 2006 Sep 27; Vol. 296 (12), pp. 1498-506.