Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Scott S. Mitchell"'
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 198
This paper describes a sensitive and selective method for the simultaneous determination of bispinacolato diboron (B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::36b4d11902446e9b6f568e7a9bec2ce6
https://pubmed.ncbi.nlm.nih.gov/33684830
https://pubmed.ncbi.nlm.nih.gov/33684830
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 198:113987
This paper describes a sensitive and selective method for the simultaneous determination of bispinacolato diboron (B2Pin2) and tetrahydroxy diboron (B2(OH)4) in a small molecule Active Pharmaceutical Ingredient (API) by gas chromatography - mass spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4290a219ded61c03c1db2e4f01a31c09
https://doi.org/10.1016/j.jpba.2021.113987
https://doi.org/10.1016/j.jpba.2021.113987
Autor:
Saskia T. C. Neuteboom, Scott S Mitchell, Barbara C. M. Potts, Jianlin Xu, Gordafaried Deyanat-Yazdi, Sy Teisan, Ta-Hsiang Chao, Katherine Anne Reed, Rama Rao Manam, Kin S. Lam
Publikováno v:
Journal of Natural Products. 70:269-276
Salinosporamide A (NPI-0052; 3), a highly potent inhibitor of the 20S proteasome, is currently in phase I clinical trials for the treatment of cancer. During the course of purifying multigram quantities of 3 from Salinispora tropica fermentation extr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d3effc54d9880cd0e7e895ffdb1e4c4
https://doi.org/10.1021/np0603471
https://doi.org/10.1021/np0603471
Autor:
Ginger Tsueng, Jianlin Xu, Scott S Mitchell, Barbara C. M. Potts, Katherine A. McArthur, Kin S. Lam
Publikováno v:
The Journal of Antibiotics. 60:13-19
We examined the effects of halogens on the production of salinosporamide A (NPI-0052) by the obligate marine actinomycete Salinispora tropica NPS465, specifically the production of analogs containing halogens other than chlorine. Adding NaF, NaBr and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6251ce366f3e451896c1f6109d721ed3
https://doi.org/10.1038/ja.2007.2
https://doi.org/10.1038/ja.2007.2
Autor:
Gordafaried Deyanat-Yazdi, Ta-Hsiang Chao, Paul R. Jensen, Bao Mai, Kin S. Lam, Barbara C. M. Potts, Michael A. Palladino, William Fenical, Saskia T. C. Neuteboom, Katherine Anne Reed, Benjamin Nicholson, Scott S Mitchell, Rama Rao Manam, Venkat R. Macherla
Publikováno v:
Journal of Medicinal Chemistry. 48:3684-3687
Salinosporamide A (1, NPI-0052) is a potent proteasome inhibitor in development for treating cancer. In this study, a series of analogues was assayed for cytotoxicity, proteasome inhibition, and inhibition of NF-kappaB activation. Marked reductions i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb6efcee18907297287cfa16b47c94b4
https://doi.org/10.1021/jm048995+
https://doi.org/10.1021/jm048995+
Publikováno v:
Tetrahedron. 55:10887-10892
Four novel diterpenoids, spongiabutenolides A – D (2–5), all of which contain a γ-hydroxybutenolide moiety, have been isolated from a Philippines marine sponge of the genus Spongia. The structures of spongiabutenolides A – D (2–5) and the me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64c42f507c4fee3a43fba697a65c3d67
https://doi.org/10.1016/s0040-4020(99)00622-5
https://doi.org/10.1016/s0040-4020(99)00622-5
Publikováno v:
The Journal of Organic Chemistry. 64:1626-1629
Polyalkyl pyran-4-ones 1a-c were irradiated in methanol or ethanol. Although the expected solvent trapping products 3 could be observed, extended irradiation times allowed exclusive formation of secondary photoproducts 4 and 5 in combined yields of 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5e82afc555064b136f45709bf62f03e
https://doi.org/10.1021/jo9821224
https://doi.org/10.1021/jo9821224
Publikováno v:
Journal of Natural Products. 67:1400-1402
During the course of our screening program designed to discover novel anticancer and anti-infective agents from marine microorganisms, a strain of Streptomyces aureoverticillatus (NPS001583) isolated from a marine sediment was found to produce a nove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d48b2fc3fa1b027080f42f8684cbceb7
https://doi.org/10.1021/np049970g
https://doi.org/10.1021/np049970g
Publikováno v:
Tetrahedron Letters. 34:4583-4586
Fused bicyclic 4-pyrones were prepared by condensation of enamines derived from cyclic ketones with diketene or substituted 1,3-dioxin-4-ones. Photolysis in a hydroxylic medium led to bicyclo[n3.0]alkenones bearing oxygenation at both angular positio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a64b3e198de10c6926d919c4f6293954
https://doi.org/10.1016/s0040-4039(00)60630-5
https://doi.org/10.1016/s0040-4039(00)60630-5
Publikováno v:
ChemInform. 24
Fused bicyclic 4-pyrones were prepared by condensation of enamines derived from cyclic ketones with diketene or substituted 1,3-dioxin-4-ones. Photolysis in a hydroxylic medium led to bicyclo[n3.0]alkenones bearing oxygenation at both angular positio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d66560e1d9d7f8ac294cbe4050cbd2a8
https://doi.org/10.1002/chin.199341116
https://doi.org/10.1002/chin.199341116