Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Scott S Terhune"'
Autor:
Kristen Zarrella, Pierce Longmire, Sebastian Zeltzer, Donna Collins-McMillen, Meaghan Hancock, Jason Buehler, Justin M Reitsma, Scott S Terhune, Jay A Nelson, Felicia Goodrum
Publikováno v:
PLoS Pathogens, Vol 19, Iss 6, p e1011185 (2023)
Innate immune responses are crucial for limiting virus infection. However, viruses often hijack our best defenses for viral objectives. Human Cytomegalovirus (HCMV) is a beta herpesvirus which establishes a life-long latent infection. Defining the vi
Externí odkaz:
https://doaj.org/article/d85e8154b8e44746b556114c61bcbb75
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 4, p e1007733 (2020)
The cellular protein-protein interaction network that governs cellular proliferation (cell cycle) is highly complex. Here, we have developed a novel computational model of human mitotic cell cycle, integrating diverse cellular mechanisms, for the pur
Externí odkaz:
https://doaj.org/article/c59759964f92401c867e9e32f62cfbd3
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42197 (2012)
Viral infection and replication involves the reorganization of the actin network within the host cell. Actin plays a central role in the mechanical properties of cells. We have demonstrated a method to quantify changes in mechanical properties of fab
Externí odkaz:
https://doaj.org/article/0233c7e10a984ca9adbdd2bcd07b270c
Publikováno v:
PLoS Pathogens, Vol 8, Iss 7, p e1002789 (2012)
The anaphase-promoting complex (APC) is an E3 ubiquitin ligase which controls ubiquitination and degradation of multiple cell cycle regulatory proteins. During infection, human cytomegalovirus (HCMV), a widespread pathogen, not only phosphorylates th
Externí odkaz:
https://doaj.org/article/910940b6c4c74edd99342692d4005d67
Autor:
Mark J White, John P Savaryn, Daniel J Bretl, Hongjun He, Renee M Penoske, Scott S Terhune, Thomas C Zahrt
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e18175 (2011)
Mycobacterium tuberculosis remains a significant global health concern largely due to its ability to persist for extended periods within the granuloma of the host. While residing within the granuloma, the tubercle bacilli are likely to be exposed to
Externí odkaz:
https://doaj.org/article/0ed22e50ddd8482392892785f5528b01
Autor:
Scott S Terhune, Nathaniel J Moorman, Ileana M Cristea, John Paul Savaryn, Christian Cuevas-Bennett, Michael P Rout, Brian T Chait, Thomas Shenk
Publikováno v:
PLoS Pathogens, Vol 6, Iss 6, p e1000965 (2010)
Histone deacetylation plays a pivotal role in regulating human cytomegalovirus gene expression. In this report, we have identified candidate HDAC1-interacting proteins in the context of infection by using a method for rapid immunoisolation of an epit
Externí odkaz:
https://doaj.org/article/555f15c0a6114f8eb23de4adf6b5baf7
Autor:
Benjamin S. O’Brien, Rebekah L. Mokry, Megan L. Schumacher, Suzette Rosas, Scott S. Terhune, Allison D. Ebert
Human cytomegalovirus (HCMV) is a beta herpesvirus that causes severe congenital birth defects including microcephaly, vision loss, and hearing loss. Infection of cerebral organoids with HCMV causes significant downregulation of genes involved in cri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fac3769ac7f03076cf44b6ac802184c
https://doi.org/10.1101/2023.03.02.530870
https://doi.org/10.1101/2023.03.02.530870
Autor:
Eleonora Forte, Ming Li, Fatma Ayaloglu Butun, Qiaolin Hu, Eva Maria Borst, Matthew J. Schipma, Andrea Piunti, Ali Shilatifard, Scott S. Terhune, Michael Abecassis, Jeffery L. Meier, Mary Hummel
Publikováno v:
Microbiology Spectrum.
HCMV is an important human pathogen associated with complications in transplant patients and birth defects. The complex program of viral gene expression is regulated by both viral proteins and host factors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a446fe84b88883fcd65b32676d6de85b
https://doi.org/10.1128/spectrum.03144-22
https://doi.org/10.1128/spectrum.03144-22
Autor:
Rebekah L. Mokry, Benjamin S. O’Brien, Jacob W. Adelman, Suzette Rosas, Megan L. Schumacher, Allison D. Ebert, Scott S. Terhune
Publikováno v:
J Virol
Human cytomegalovirus (HCMV) is a prevalent betaherpesvirus that is asymptomatic in healthy individuals but can cause serious disease in immunocompromised patients. HCMV is also the leading cause of virus-mediated birth defects. Many of these defects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed645e1002a0cd004271e832ed405ea3
https://europepmc.org/articles/PMC9327702/
https://europepmc.org/articles/PMC9327702/
Autor:
Emily R. Albright, Kylee Morrison, Padhma Ranganathan, Dominique M. Carter, Masaki Nishikiori, Jeong-Hee Lee, Mark D. Slayton, Paul Ahlquist, Scott S. Terhune, Robert F. Kalejta
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(14)
Replication-dependent (RD) histones are deposited onto human cytomegalovirus (HCMV) genomes at the start of infection. We examined how HCMV affects the de novo production of RD histones and found that viral infection blocked the accumulation of RD hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acbc38be5585524787ab24978f30a310
https://pubmed.ncbi.nlm.nih.gov/35344424
https://pubmed.ncbi.nlm.nih.gov/35344424