Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Scott Ryall"'
Autor:
Adrian B. Levine, Liana Nobre, Anirban Das, Scott Milos, Vanessa Bianchi, Monique Johnson, Nicholas R. Fernandez, Lucie Stengs, Scott Ryall, Michelle Ku, Mansuba Rana, Benjamin Laxer, Javal Sheth, Stefanie-Grace Sbergio, Ivana Fedoráková, Vijay Ramaswamy, Julie Bennett, Robert Siddaway, Uri Tabori, Cynthia Hawkins
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract With the success of immunotherapy in cancer, understanding the tumor immune microenvironment (TIME) has become increasingly important; however in pediatric brain tumors this remains poorly characterized. Accordingly, we developed a clinical
Externí odkaz:
https://doaj.org/article/8dae6a790c504336bebc7af3d67dc268
Autor:
Rawan Hammad, Liana Nobre, Scott Ryall, Anthony Arnoldo, Robert Siddaway, Julie Bennett, Uri Tabori, Cynthia Hawkins
Publikováno v:
JCO Global Oncology, Vol , Iss 10 (2024)
PURPOSEMolecular characterization is key to optimally diagnose and manage cancer. The complexity and cost of routine genomic analysis have unfortunately limited its use and denied many patients access to precision medicine. A possible solution is to
Externí odkaz:
https://doaj.org/article/0593f46bbcbe42b79cd7892d111b6dd1
Autor:
Robert Siddaway, Scott Milos, Arun Kumaran Anguraj Vadivel, Tara H. W. Dobson, Jyothishmathi Swaminathan, Scott Ryall, Sanja Pajovic, Palak G. Patel, Javad Nazarian, Oren Becher, Michael Brudno, Arun Ramani, Vidya Gopalakrishnan, Cynthia Hawkins
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Targeting genetic drivers of high grade diffuse glioma (HGG) has not improved patient survival, suggesting the involvement of other mechanisms. Here, across cancer types, the authors identify increased alternative splicing burden in cancer drivers co
Externí odkaz:
https://doaj.org/article/16682e61ebb34dd9b0ee5d0b70707f1e
Autor:
Sanja Pajovic, Robert Siddaway, Taylor Bridge, Javal Sheth, Patricia Rakopoulos, Byungjin Kim, Scott Ryall, Sameer Agnihotri, Lauren Phillips, Man Yu, Christopher Li, Scott Milos, Palak Patel, Dilakshan Srikanthan, Annie Huang, Cynthia Hawkins
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Histone H3 at lysine 27 (H3K27M) is often mutated in cancer but its role in tumour initiation is unclear. Here, the authors generated a transgenic model expressing H3.3K27M from the Fabp7 gene promoter, demonstrating that H3.3K27M can initiate divers
Externí odkaz:
https://doaj.org/article/d2950e03eca24abe9198eff022010cfc
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-22 (2020)
Abstract Low grade gliomas are the most frequent brain tumors in children and encompass a spectrum of histologic entities which are currently assigned World Health Organisation grades I and II. They differ substantially from their adult counterparts
Externí odkaz:
https://doaj.org/article/1440370edd8245568bce0a1aa72f70b4
Autor:
Ana S. Guerreiro Stucklin, Scott Ryall, Kohei Fukuoka, Michal Zapotocky, Alvaro Lassaletta, Christopher Li, Taylor Bridge, Byungjin Kim, Anthony Arnoldo, Paul E. Kowalski, Yvonne Zhong, Monique Johnson, Claire Li, Arun K. Ramani, Robert Siddaway, Liana Figueiredo Nobre, Pasqualino de Antonellis, Christopher Dunham, Sylvia Cheng, Daniel R. Boué, Jonathan L. Finlay, Scott L. Coven, Inmaculada de Prada, Marta Perez-Somarriba, Claudia C. Faria, Michael A. Grotzer, Elisabeth Rushing, David Sumerauer, Josef Zamecnik, Lenka Krskova, Miguel Garcia Ariza, Ofelia Cruz, Andres Morales La Madrid, Palma Solano, Keita Terashima, Yoshiko Nakano, Koichi Ichimura, Motoo Nagane, Hiroaki Sakamoto, Maria Joao Gil-da-Costa, Roberto Silva, Donna L. Johnston, Jean Michaud, Bev Wilson, Frank K. H. van Landeghem, Angelica Oviedo, P. Daniel McNeely, Bruce Crooks, Iris Fried, Nataliya Zhukova, Jordan R. Hansford, Amulya Nageswararao, Livia Garzia, Mary Shago, Michael Brudno, Meredith S. Irwin, Ute Bartels, Vijay Ramaswamy, Eric Bouffet, Michael D. Taylor, Uri Tabori, Cynthia Hawkins
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Infant gliomas behave differently to their childhood or adult counterparts. Here, the authors perform a large-scale genetic analysis of these tumours, revealing genetic alterations which may offer therapeutic opportunities.
Externí odkaz:
https://doaj.org/article/1dd77b35b12f4fbfa3be4dbd3feb1c2b
Autor:
Liana Nobre, Adrian Levine, Scott Milos, Monique Johnson, Ben Laxer, Scott Ryall, Julie Bennett, Michelle Ku, Robert Siddaway, Uri Tabori, Cynthia Hawkins
Publikováno v:
Neuro-Oncology. 24:vii5-vii6
The deregulation of canonical oncogenic pathways are largely responsible for driving pediatric cancers and can be targeted for therapeutics. Currently, we interrogate these pathways clinically by looking for gene mutations, but these are not found in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::020bf4f0961e5690d71ab14f471c89fd
https://doi.org/10.1093/neuonc/noac209.019
https://doi.org/10.1093/neuonc/noac209.019
Autor:
Adrian Levine, Liana Nobre, Scott Milos, Anirban Das, Monique Johnson, Ben Laxer, Scott Ryall, Robert Siddaway, Uri Tabori, Cynthia Hawkins
Publikováno v:
Neuro-Oncology. 24:vii133-vii133
The tumor immune microenvironment (TIME) is a growing area of interest, however, the extent of immune activation in childhood CNS tumors is unknown. Although immunotherapy has not gained success in most CNS cancers, our group described gliomas with M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::556b156eb29f9172a6cdc08596c3f1a0
https://doi.org/10.1093/neuonc/noac209.507
https://doi.org/10.1093/neuonc/noac209.507
Autor:
Julie Bennett, Liana Nobre, Javal Sheth, Scott Ryall, Karen Fang, Monique Johnson, Logine Negm, Jiil Chung, Martin Komosa, Nuno Nunes, Mary Jane Lim-Fat, James Perry, Arjun Sahgal, Jay Detsky, Eric Bouffet, Lili-Naz Hazrati, Peter Dirks, Birgit Ertl-Wagner, Paul Kongkham, Gelareh Zadeh, Warren Mason, Michael Cusimano, Sunit Das, Andrew Gao, Derek Tsang, Lananh Nguyen, Normand Laperriere, Julia Keith, David Munoz, Uri Tabori, Cynthia Hawkins
Publikováno v:
Neuro-Oncology. 24:vii115-vii115
OBJECTIVE Gliomas in adolescents and young adults (AYA) are commonly treated with a standard chemo-radiation approach. Molecular alterations have not been comprehensively described to date. METHODS We compiled a multi-institutional cohort of patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::419367b2087145aab856aa33ff9d9c77
https://doi.org/10.1093/neuonc/noac209.435
https://doi.org/10.1093/neuonc/noac209.435