Výsledky vyhledávání - "Scott Runyon"

Akademický článek

Androgen receptor monomers and dimers regulate opposing biological processes in prostate cancer cells

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)

Abstract Most prostate cancers express the androgen receptor (AR), and tumor growth and progression are facilitated by exceptionally low levels of systemic or intratumorally produced androgens. Thus, absolute inhibition of the androgen signaling axis

Externí odkaz: https://doaj.org/article/46ae3691cddb47bb9982590cd3da970d

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Akademický článek

Structure–Activity Relationship Development Efforts towards Peripherally Selective Analogs of the Cannabinoid Receptor Partial Agonist BAY 59-3074

Autor: George Amato, Vineetha Vasukuttan, Danni Harris, Lucas Laudermilk, Jennifer Lucitti, Scott Runyon, Rangan Maitra

Publikováno v: Molecules, Vol 27, Iss 17, p 5672 (2022)

Selective modulation of peripheral cannabinoid receptors (CBRs) has potential therapeutic applications in medical conditions, including obesity, diabetes, liver diseases, GI disorders and pain. While there have been considerable efforts to produce se

Externí odkaz: https://doaj.org/article/c6b92781d8634a3b8718e9bbf0b5f6e7

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Manipulation Under Anesthesia is Safe After Cementless Total Knee Arthroplasty: A Multicenter Study

Autor: Trevor R. Grace, Graham S. Goh, R. Scott Runyon, Ilan Small, Joseph T. Gibian, Ryan M. Nunley, Jess H. Lonner

Publikováno v: The Journal of Arthroplasty. 38:372-375

Cementless total knee arthroplasty (TKA) is thought to facilitate durable, biological fixation between the bone and implant. However, the 4-12 weeks required for osseointegration coincides with the optimal timeframe to perform a manipulation under an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38214306f2045177d6d5213e296f9b7f
https://doi.org/10.1016/j.arth.2022.08.035

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Akademický článek

Identification of a Novel Neuropeptide S Receptor Antagonist Scaffold Based on the SHA-68 Core

Autor: Allison Zarkin, Rajwana Jahan, Rajendra Uprety, Yanan Zhang, Charles McElhinny, Rodney Snyder, Elaine Gay, Gabriel Jewula, Heather Bool, Stewart D Clark, Scott Runyon

Publikováno v: Pharmaceuticals, Vol 14, Iss 10, p 1024 (2021)

Activation of the neuropeptide S receptor (NPSR) system has been shown to produce anxiolytic-like actions, arousal, and enhance memory consolidation, whereas blockade of the NPSR has been shown to reduce relapse to substances of abuse and duration of

Externí odkaz: https://doaj.org/article/774898e303094257a56345421ce84511

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Efficacy and Selectivity of Monovalent and Bivalent Vaccination Strategies to Protect against Exposure to Carfentanil, Fentanyl, and Their Mixtures in Rats

Autor: Bethany Crouse, Mariah M. Wu, Valeria Gradinati, Andrew J. Kassick, Daihyun Song, Rajwana Jahan, Saadyah Averick, Scott Runyon, Sandra D. Comer, Marco Pravetoni

Publikováno v: ACS Pharmacol Transl Sci

[Image: see text] Drug-related fatal overdoses have significantly increased in the past decade due to the widespread availability of illicit fentanyl and other potent synthetic opioids such as carfentanil. Deliberate or accidental consumption or expo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56ca0f7202452fc21bffc599fe5d5441
https://doi.org/10.1021/acsptsci.1c00260

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