Zobrazeno 1 - 10
of 280
pro vyhledávání: '"Scott Rector"'
Publikováno v:
Cells, Vol 13, Iss 20, p 1673 (2024)
Curcumin, a polyphenolic compound derived from the widely used spice Curcuma longa, has shown anti-atherosclerotic effects in animal models and cultured vascular cells. Inflammation is a major contributor to atherosclerosis development and progressio
Externí odkaz:
https://doaj.org/article/951da8c5e21541baabfef6ba0cd6bfda
Autor:
Megan M. Knuth, Jing Xue, Marwa Elnagheeb, Raad Z. Gharaibeh, Sarah A. Schoenrock, Susan McRitchie, Cory Brouwer, Susan J. Sumner, Lisa Tarantino, William Valdar, R. Scott Rector, Jeremy M. Simon, Folami Ideraabdullah
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
IntroductionEmerging data suggests liver disease may be initiated during development when there is high genome plasticity and the molecular pathways supporting liver function are being developed.MethodsHere, we leveraged our Collaborative Cross mouse
Externí odkaz:
https://doaj.org/article/8293d185b25b4bafb987226841c7403f
Autor:
Taylor J. Kelty, Chris L. Taylor, Nicole E. Wieschhaus, Pamela K. Thorne, Amira R. Amin, Christina M. Mueller, T. Dylan Olver, Darla L. Tharp, Craig A. Emter, Alexander W. Caulk, R. Scott Rector
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Diet-induced obesity is implicated in the development of a variety of neurodegenerative disorders. Concurrently, the loss of mitochondrial Complex I protein or function is emerging as a key phenotype across an array of neurodegenerative disorders. Th
Externí odkaz:
https://doaj.org/article/77e17acae05643758ef8bc4dc5d12d33
Autor:
Ming Yang, Xiaoqiang Qi, Nan Li, Jussuf T. Kaifi, Shiyou Chen, Andrew A. Wheeler, Eric T. Kimchi, Aaron C. Ericsson, R. Scott Rector, Kevin F. Staveley-O’Carroll, Guangfu Li
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract The interplay between western diet and gut microbiota drives the development of non-alcoholic fatty liver disease and its progression to non-alcoholic steatohepatitis. However, the specific microbial and metabolic mediators contributing to n
Externí odkaz:
https://doaj.org/article/b4b77dd13ef64968b1d1ab140e504033
Autor:
Alexander P. Earhart, Natalia G. Karasseva, Kathryn M. Storey, Benjamin Olthoff, Md Bodruzzaman Sarker, Kimberly G. Laffey, Margaret J. Lange, R. Scott Rector, Laura C. Schulz, Diana Gil, Claudia M. Neuhauser, Adam G. Schrum
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 113007- (2023)
Summary: Immune responses differ between females and males, although such sex-based variance is incompletely understood. Observing that bacteremia of the opportunistic pathogen Burkholderia gladioli caused many more deaths of female than male mice be
Externí odkaz:
https://doaj.org/article/1e4d898742b04a9995b7b49b3e3deaf5
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 5, Pp 100366- (2023)
Ceramides (CERs) are key intermediate sphingolipids implicated in contributing to mitochondrial dysfunction and the development of multiple metabolic conditions. Despite the growing evidence of CER role in disease risk, kinetic methods to measure CER
Externí odkaz:
https://doaj.org/article/b534db1adc3f4fb0b6783ce0dd43a9f6
Autor:
Mary Patricia Moore, Xiaobo Wang, Hongxue Shi, Marica Meroni, Alessandro Cherubini, Luisa Ronzoni, Elizabeth J. Parks, Jamal A. Ibdah, R. Scott Rector, Luca Valenti, Paola Dongiovanni, Ira Tabas
Publikováno v:
JHEP Reports, Vol 5, Iss 5, Pp 100716- (2023)
Background & Aims: Non-alcoholic steatohepatitis (NASH)-induced liver fibrosis is emerging as the most common cause of liver disease. For evaluation of therapies, there is a pressing need to identify non-invasive, mechanism-based biomarkers. A pro-fi
Externí odkaz:
https://doaj.org/article/442c0fe10db54f3689cbe3e11fb86a15
Autor:
Justine M. Mucinski, Alisha M. Perry, Talyia M. Fordham, Alberto Diaz-Arias, Jamal A. Ibdah, R. Scott Rector, Elizabeth J. Parks
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
In vivo methods to estimate human liver mitochondrial activity are lacking and this project’s goal was to use a non-invasive breath test to quantify complete mitochondrial fat oxidation and determine how test results changed when liver disease stat
Externí odkaz:
https://doaj.org/article/a48b01b8f0d84ddf8ced6f0fa221533b
Autor:
Kelsey A. Rushing, Mickey L. Bolyard, Taylor Kelty, Nicole Wieschhaus, Gregory Pavela, R. Scott Rector, Eric P. Plaisance
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Objective: The ketone diester, R,S-1,3-butanediol diacetoacetate (BD-AcAc2), attenuates the accretion of adiposity and reduces hepatic steatosis in high-fat diet-induced obese mice when carbohydrate energy is removed from the diet to accommodate ener
Externí odkaz:
https://doaj.org/article/11aff1e5ec294cf4b24dd24f78df5b5e
Autor:
Nathan R. Kerr, Taylor J. Kelty, Xuansong Mao, Thomas E. Childs, David D. Kline, R. Scott Rector, Frank W. Booth
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
Physical inactivity is the 4th leading cause of death globally and has been shown to significantly increase the risk for developing Alzheimer’s Disease (AD). Recent work has demonstrated that exercise prior to breeding produces heritable benefits t
Externí odkaz:
https://doaj.org/article/2f613e6b9f704748aee29e529cd6e607