Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Scott Rata"'
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2023)
Antiangiogenic therapy began as an effort to inhibit VEGF signaling, which was thought to be the sole factor driving tumor angiogenesis. It has become clear that there are more pro-angiogenic growth factors that can substitute for VEGF during tumor v
Externí odkaz:
https://doaj.org/article/0f0c4159d5b640939485cac0c285dbec
Antiangiogenic therapy began as an effort to inhibit VEGF signaling, which was thought to be the sole factor driving tumor angiogenesis. It has become clear that there are more pro-angiogenic growth factors that can participate in and can substitute
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3af4dc35653eaa163e401f74982b2559
https://doi.org/10.1101/2021.02.28.433132
https://doi.org/10.1101/2021.02.28.433132
Autor:
Scott Rata, Alexander A. Lukyanov, Craig J. Thomas, Michele Ceribelli, Natalia Trikoz, Janelle Vultaggio, Jonathan Scott Gruver, Marc W. Kirschner, Leonid Peshkin, Taran Gujral
We present a comprehensive resource of 257 kinase inhibitor profiles against 365 human protein kinases using gold-standard kinase activity assays. We show the utility of this dataset with an improved version of Kinome Regularization (KiR) to deconvol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b932d006b393a7b838473daef8708515
https://doi.org/10.1101/2020.09.26.312348
https://doi.org/10.1101/2020.09.26.312348
Publikováno v:
BioEssays. 38:627-643
Mitotic entry and exit are switch-like transitions that are driven by the activation and inactivation of Cdk1 and mitotic cyclins. This simple on/off reaction turns out to be a complex interplay of various reversible reactions, feedback loops, and th
Publikováno v:
Current Biology
Publikováno v:
Cell cycle (Georgetown, Tex.). 16(20)
The transitions between phases of the cell cycle have evolved to be robust and switch-like, which ensures temporal separation of DNA replication, sister chromatid separation, and cell division. Mathematical models describing the biochemical interacti
Autor:
Thomas Brown, Francoise S. Howe, Struan C. Murray, Emily Seward, Scott Rata, Andrew Angel, Jane Mellor
Antisense transcription is widespread in genomes. Despite large differences in gene size and architecture, we find that yeast and human genes share a unique, antisense transcription-associated chromatin signature. We asked whether this signature is r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb70afee7b987d4a2bea43d699fb78e3