Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Scott R. Witting"'
Autor:
Loren E. Faulkner, Stacey E. Panagotopulos, Jacob D. Johnson, Laura A. Woollett, David Y. Hui, Scott R. Witting, J. Nicholas Maiorano, W. Sean Davidson
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 6, Pp 1322-1332 (2008)
The ATP binding cassette transporter A-1 (ABCA1) is critical for apolipoprotein-mediated cholesterol efflux, an important mechanism employed by macrophages to avoid becoming lipid-laden foam cells, the hallmark of early atherosclerotic lesions. It ha
Externí odkaz:
https://doaj.org/article/903c0ccd8d83446faf8392dea598e231
Autor:
Núria Morral, Howard J. Edenberg, Scott R. Witting, Jennifer Altomonte, Tearina Chu, Matthew Brown
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 7, Pp 1499-1510 (2007)
Glucose disposal induces a signal that modulates the transcriptional regulation of genes involved in the glycolysis and lipogenesis pathways. To investigate the role of glucose metabolism on hepatic gene expression independently from insulin action,
Externí odkaz:
https://doaj.org/article/3729f6722e8642e88d5630541486d837
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1937
Lentiviral vectors have rapidly become a favorite tool for research and clinical gene transfer applications which seek to permanently introduce alterations in the genome. This status can be attributed primarily to their ability to transduce dividing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8cd07a4cc4091e252650fba11a9002b5
https://pubmed.ncbi.nlm.nih.gov/30706394
https://pubmed.ncbi.nlm.nih.gov/30706394
Publikováno v:
Gene therapy
Lentiviruses are becoming progressively more popular as gene therapy vectors due to their ability to integrate into quiescent cells and recent clinical trial successes. Directing these vectors to specific cell types and limiting off-target transducti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c118bee599e0003cf0ddf6899e820c9b
https://doi.org/10.1038/gt.2013.23
https://doi.org/10.1038/gt.2013.23
Autor:
Scott R. Witting, Aparna Jasti, Lakshmi Sastry-Dent, Kenneth Cornetta, Guiandre L. Joseph, Aaron Shaw
Publikováno v:
Gene therapy
A variety of mutations in lentiviral vector expression systems have been shown to generate a non-integrating phenotype. We studied a novel 12 base-pair U3-long terminal repeats (LTR) integrase (IN) attachment site deletion (U3-LTR att site) mutant an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6861f3c238d2f9d1c29d16b8b878354
https://pubmed.ncbi.nlm.nih.gov/27682478
https://pubmed.ncbi.nlm.nih.gov/27682478
Publikováno v:
Journal of Controlled Release. 144:91-100
article i nfo Genetic modification of cells is a critical step involved in many cell therapy and gene therapy protocols. In these applications, cell samples of large volume (10 8 -10 9 cells) are often processed for transfection. This poses new chall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3c0e986738ed8fc34cfec82c4f0a506
https://doi.org/10.1016/j.jconrel.2010.01.030
https://doi.org/10.1016/j.jconrel.2010.01.030
Autor:
Tearina Chu, Matthew Brown, Jennifer Altomonte, Howard J. Edenberg, Núria Morral, Scott R. Witting
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 7, Pp 1499-1510 (2007)
Glucose disposal induces a signal that modulates the transcriptional regulation of genes involved in the glycolysis and lipogenesis pathways. To investigate the role of glucose metabolism on hepatic gene expression independently from insulin action,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c74d8c9708cbfa68afdd48eccdead34
http://www.sciencedirect.com/science/article/pii/S0022227520425349
http://www.sciencedirect.com/science/article/pii/S0022227520425349
Autor:
Stacey E. Panagotopulos, J. Nicholas Maiorano, David Y. Hui, Erica M. Horace, W. Sean Davidson, Scott R. Witting
Publikováno v:
Journal of Biological Chemistry. 277:39477-39484
Recent studies of Tangier disease have shown that the ATP-binding cassette transporter A1 (ABCA1)/apolipoprotein A-I (apoA-I) interaction is critical for high density lipoprotein particle formation, apoA-I integrity, and proper reverse cholesterol tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc5602f6ac2c820e593dda42d1dac772
https://doi.org/10.1074/jbc.m207005200
https://doi.org/10.1074/jbc.m207005200
Autor:
Miwon Ahn, Scott R. Witting, Sneha Surendran, Silvana Obici, Aisha Gamble, Jack Magrisso, Núria Morral
Helper-dependent adenoviral vectors (HD Ad) hold extreme promise for gene therapy of human diseases. All viral genes are deleted in HD Ad vectors, and therefore, the presence of a helper virus is required for their production. Current methods to mini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9d4f6b2034f7de2bfe0a4ca058644fe
https://europepmc.org/articles/PMC4015077/
https://europepmc.org/articles/PMC4015077/
Autor:
Scott R. Witting, Núria Morral
Publikováno v:
Pharmaceutical Sciences Encyclopedia
The first RNA silencing mechanisms were discovered as part of an antiviral response believed to protect organisms from viral infection. It was later discovered that cells have the capacity to synthesize small RNAs known as microRNA (miRNA), which reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19713e6b464fe1ec18b4eff42ecd5746
https://doi.org/10.1002/9780470571224.pse434
https://doi.org/10.1002/9780470571224.pse434