Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Scott R. McKercher"'
Autor:
Shu-ichi Okamoto, Olga Prikhodko, Juan Pina-Crespo, Anthony Adame, Scott R. McKercher, Laurence M. Brill, Nobuki Nakanishi, Chang-ki Oh, Tomohiro Nakamura, Eliezer Masliah, Stuart A. Lipton
Publikováno v:
Neurobiology of Disease, Vol 127, Iss , Pp 390-397 (2019)
Tuberous sclerosis (TSC) is an autosomal dominant disorder caused by heterozygous mutations in the TSC1 or TSC2 gene. TSC is often associated with neurological, cognitive, and behavioral deficits. TSC patients also express co-morbidity with anxiety a
Externí odkaz:
https://doaj.org/article/a572bd40338d4b15b09c31e72f6e65cb
Autor:
Shichun Tu, Mohd Waseem Akhtar, Rosa Maria Escorihuela, Alejandro Amador-Arjona, Vivek Swarup, James Parker, Jeffrey D. Zaremba, Timothy Holland, Neha Bansal, Daniel R. Holohan, Kevin Lopez, Scott D. Ryan, Shing Fai Chan, Li Yan, Xiaofei Zhang, Xiayu Huang, Abdullah Sultan, Scott R. McKercher, Rajesh Ambasudhan, Huaxi Xu, Yuqiang Wang, Daniel H. Geschwind, Amanda J. Roberts, Alexey V. Terskikh, Robert A. Rissman, Eliezer Masliah, Stuart A. Lipton, Nobuki Nakanishi
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Human MEF2C haploinsufficiency results in Autism Spectrum Disorder (ASD), but it is unclear if the same is true in mice. Here, the authors show that Mef2c +/− mice have behavioral defects and neuronal abnormalities similar to ASD, and symptoms can
Externí odkaz:
https://doaj.org/article/386d48d4311a447bb8bff05a85d294e7
Autor:
Mohd Waseem Akhtar, Sara Sanz-Blasco, Nima Dolatabadi, James Parker, Kevin Chon, Michelle S. Lee, Walid Soussou, Scott R. McKercher, Rajesh Ambasudhan, Tomohiro Nakamura, Stuart A. Lipton
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Alzheimer's disease is linked to metabolic syndrome and Type-2 diabetes, but the mechanism behind this association is unclear. Here, the authors show that elevated glucose and amyloid ß work together to increase nitrosative stress, leading to aberra
Externí odkaz:
https://doaj.org/article/9fb0c0af61564f9ba2f975e9d457f235
Autor:
Tomohiro Nakamura, Olga A. Prikhodko, Elaine Pirie, Saumya Nagar, Mohd Waseem Akhtar, Chang-Ki Oh, Scott R. McKercher, Rajesh Ambasudhan, Shu-ichi Okamoto, Stuart A. Lipton
Publikováno v:
Neurobiology of Disease, Vol 84, Iss , Pp 99-108 (2015)
Nitric oxide (NO) is a gasotransmitter that impacts fundamental aspects of neuronal function in large measure through S-nitrosylation, a redox reaction that occurs on regulatory cysteine thiol groups. For instance, S-nitrosylation regulates enzymatic
Externí odkaz:
https://doaj.org/article/f1f59b9dd3d54f7b9aa8622cf6a1bca9
Autor:
Shing Fai Chan, Xiayu Huang, Scott R. McKercher, Rameez Zaidi, Shu-ichi Okamoto, Nobuki Nakanishi, Stuart A. Lipton
Publikováno v:
Genomics Data, Vol 3, Iss C, Pp 24-27 (2015)
The myocyte enhancer factor 2 (MEF2) family of transcription factors is highly expressed in the brain and constitutes a key determinant of neuronal survival, differentiation, and synaptic plasticity. However, genome-wide transcriptional profiling of
Externí odkaz:
https://doaj.org/article/73e8eb511c4f452183a4c921aa1f0c04
S-Nitrosylation-Mediated Redox Transcriptional Switch Modulates Neurogenesis and Neuronal Cell Death
Autor:
Shu-ichi Okamoto, Tomohiro Nakamura, Piotr Cieplak, Shing Fai Chan, Evgenia Kalashnikova, Lujian Liao, Sofiyan Saleem, Xuemei Han, Arjay Clemente, Anthony Nutter, Sam Sances, Christopher Brechtel, Daniel Haus, Florian Haun, Sara Sanz-Blasco, Xiayu Huang, Hao Li, Jeffrey D. Zaremba, Jiankun Cui, Zezong Gu, Rana Nikzad, Anne Harrop, Scott R. McKercher, Adam Godzik, John R. Yates III, Stuart A. Lipton
Publikováno v:
Cell Reports, Vol 8, Iss 1, Pp 217-228 (2014)
Redox-mediated posttranslational modifications represent a molecular switch that controls major mechanisms of cell function. Nitric oxide (NO) can mediate redox reactions via S-nitrosylation, representing transfer of an NO group to a critical protein
Externí odkaz:
https://doaj.org/article/5bad9d4b59a14aecaae51657fd3f11ee
Autor:
Takumi Satoh, Romain Stalder, Scott R. McKercher, Robert E. Williamson, Gregory P. Roth, Stuart A. Lipton
Publikováno v:
ASN Neuro, Vol 7 (2015)
Activation of the Kelch-like ECH-associated protein 1/nuclear factor (erythroid-derived 2)-like 2 and heat-shock protein 90/heat-shock factor-1 signal-transduction pathways plays a central role in combatting cellular oxidative damage and related endo
Externí odkaz:
https://doaj.org/article/6df3e9a0b37f424eb887b8d783eaf62f
Autor:
Chang-ki Oh, Tomohiro Nakamura, Nathan Beutler, Xu Zhang, Juan Piña-Crespo, Maria Talantova, Swagata Ghatak, Dorit Trudler, Lauren N. Carnevale, Scott R. McKercher, Malina A. Bakowski, Jolene K. Diedrich, Amanda J. Roberts, Ashley K. Woods, Victor Chi, Anil K. Gupta, Mia A. Rosenfeld, Fiona L. Kearns, Lorenzo Casalino, Namir Shaabani, Hejun Liu, Ian A. Wilson, Rommie E. Amaro, Dennis R. Burton, John R. Yates, Cyrus Becker, Thomas F. Rogers, Arnab K. Chatterjee, Stuart A. Lipton
Publikováno v:
Nat Chem Biol
bioRxiv
Nature chemical biology, vol 19, iss 3
bioRxiv
Nature chemical biology, vol 19, iss 3
Prevention of infection and propagation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a high priority in the Coronavirus Disease 2019 (COVID-19) pandemic. Here we describe S-nitrosylation of multiple proteins involved in SARS-CoV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c56dbbfbb07a25bd2fb1950e211865c3
https://europepmc.org/articles/PMC10127945/
https://europepmc.org/articles/PMC10127945/
Autor:
Chang-ki Oh, Tomohiro Nakamura, Nathan Beutler, Xu Zhang, Juan Piña-Crespo, Maria Talantova, Swagata Ghatak, Dorit Trudler, Lauren N. Carnevale, Scott R. McKercher, Malina A. Bakowski, Jolene K. Diedrich, Amanda J. Roberts, Ashley K. Woods, Victor Chi, Anil K. Gupta, Mia A. Rosenfeld, Fiona L. Kearns, Lorenzo Casalino, Namir Shaabani, Hejun Liu, Ian A. Wilson, Rommie E. Amaro, Dennis R. Burton, John R. Yates, Cyrus Becker, Thomas F. Rogers, Arnab K. Chatterjee, Stuart A. Lipton
Prevention of infection and propagation of SARS-CoV-2 is of high priority in the COVID-19 pandemic. Here, we describe S-nitrosylation of multiple proteins involved in SARS-CoV-2 infection, including angiotensin converting enzyme 2 (ACE2), the recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58752c9c933d0e60be78b4110ba8ac35
https://doi.org/10.1101/2022.04.05.487060
https://doi.org/10.1101/2022.04.05.487060
Publikováno v:
Annual Review of Pharmacology and Toxicology. 61:701-721
Excitatory/inhibitory (E/I) balance, defined as the balance between excitation and inhibition of synaptic activity in a neuronal network, accounts in part for the normal functioning of the brain, controlling, for example, normal spike rate. In many p