Zobrazeno 1 - 10
of 188
pro vyhledávání: '"Scott R. Manalis"'
Autor:
Alex B. Miller, Felicia H. Rodriguez, Adam Langenbucher, Lin Lin, Christina Bray, Sarah Duquette, Ye Zhang, Dan Goulet, Andrew A. Lane, David M. Weinstock, Michael T. Hemann, Scott R. Manalis
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-10 (2024)
Abstract Leukemias and their bone marrow microenvironments undergo dynamic changes over the course of disease. However, little is known about the circulation kinetics of leukemia cells, nor the impact of specific factors on the clearance of circulati
Externí odkaz:
https://doaj.org/article/d7dcccfc6e274a74a593913922844621
Autor:
Benjamin R. K. Roller, Cathrine Hellerschmied, Yanqi Wu, Teemu P. Miettinen, Annika L. Gomez, Scott R. Manalis, Martin F. Polz
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT Optical density is a proxy of total biomass concentration and is commonly used for measuring the growth of bacterial cultures. However, there is a misconception that exponential optical density growth is equivalent to steady-state population
Externí odkaz:
https://doaj.org/article/e1f73d00d0004d3f84893f14f7095ebe
Autor:
Lydie Debaize, Ye Zhang, Michelle Ramseier, Mingzeng Zhang, Adam Langenbucher, Peter S. Winter, Ran Xu, Nezha Senhaji, Robert A Redd, Martin J. Aryee, Paul H. Branch, Austin I. Kim, David M. Weinstock, Alex Shalek, Scott R. Manalis, Mark A. Murakami
Publikováno v:
HemaSphere, Vol 7, p e96705d3 (2023)
Externí odkaz:
https://doaj.org/article/713cb23b4f6148cd99681bf90cefde7a
Autor:
Bashar Hamza, Alex B. Miller, Lara Meier, Max Stockslager, Sheng Rong Ng, Emily M. King, Lin Lin, Kelsey L. DeGouveia, Nolawit Mulugeta, Nicholas L. Calistri, Haley Strouf, Christina Bray, Felicia Rodriguez, William A. Freed-Pastor, Christopher R. Chin, Grissel C. Jaramillo, Megan L. Burger, Robert A. Weinberg, Alex K. Shalek, Tyler Jacks, Scott R. Manalis
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Current methods for acquiring dissemination kinetics of rare circulating tumor cells (CTCs) that form metastases have several limitations. Here, the authors show an approach for measuring endogenous CTC kinetics by continuously exchanging CTC-contain
Externí odkaz:
https://doaj.org/article/a01832348b58404486e05ba5132c7532
Autor:
Georgios Katsikis, Jesse F. Collis, Scott M. Knudsen, Vincent Agache, John E. Sader, Scott R. Manalis
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-6 (2021)
Balances for nanoparticles such as resonating fluid-filled cantilevers usually probe only mass through changes in oscillation frequency. Katsikis and Collis et al. tap information from previously ignored rotational motion to simultaneously measure pa
Externí odkaz:
https://doaj.org/article/054d72a9638840718cdb43f88068e024
Autor:
Andreas L. Gimpel, Georgios Katsikis, Sha Sha, Andrew John Maloney, Moo Sun Hong, Tam N.T. Nguyen, Jacqueline Wolfrum, Stacy L. Springs, Anthony J. Sinskey, Scott R. Manalis, Paul W. Barone, Richard D. Braatz
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss , Pp 740-754 (2021)
The optimization of upstream and downstream processes for production of recombinant adeno-associated virus (rAAV) with consistent quality depends on the ability to rapidly characterize critical quality attributes (CQAs). In the context of rAAV produc
Externí odkaz:
https://doaj.org/article/5639116648734b5c98572ecf550d8966
Autor:
Joon Ho Kang, Georgios Katsikis, Zhaoqi Li, Kiera M. Sapp, Max A. Stockslager, Daniel Lim, Matthew G. Vander Heiden, Michael B. Yaffe, Scott R. Manalis, Teemu P. Miettinen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
ATP drives most cellular processes, although ATP production and consumption levels during mitosis remain unreported. Here, the authors combine metabolic measurements and modeling to quantify ATP levels and synthesis dynamics, revealing that ATP synth
Externí odkaz:
https://doaj.org/article/7d36fb2261454301970a2d8ba6a0530b
Autor:
Max A. Stockslager, Seth Malinowski, Mehdi Touat, Jennifer C. Yoon, Jack Geduldig, Mahnoor Mirza, Annette S. Kim, Patrick Y. Wen, Kin-Hoe Chow, Keith L. Ligon, Scott R. Manalis
Publikováno v:
Cell Reports, Vol 37, Iss 1, Pp 109788- (2021)
Summary: Functional precision medicine aims to match individual cancer patients to optimal treatment through ex vivo drug susceptibility testing on patient-derived cells. However, few functional diagnostic assays have been validated against patient o
Externí odkaz:
https://doaj.org/article/e91ca42247b7413da4ad84cd61fab80b
Autor:
Clare R. Harding, Matthew Gow, Joon Ho Kang, Emily Shortt, Scott R. Manalis, Markus Meissner, Sebastian Lourido
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Cortical microtubules of Toxoplasma gondii are exceptionally stable, but it isn’t known how they are anchored along membranes. Here, Harding et al. show that GAPM proteins localize to the inner membrane complex and are essential for maintaining the
Externí odkaz:
https://doaj.org/article/766fd260c7ed44caaa4862fd02dabe79
Autor:
Nicholas L. Calistri, Robert J. Kimmerling, Seth W. Malinowski, Mehdi Touat, Mark M. Stevens, Selim Olcum, Keith L. Ligon, Scott R. Manalis
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-7 (2018)
Single-cell detection methods are limited by the trade-off between flow rate and measurement precision. Here the authors introduce active loading, an optically triggered microfluidic system to concentrate diluted cell samples, which reduces clogging
Externí odkaz:
https://doaj.org/article/87b9574143a84e82ab152a42f9a0ce1c