Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Scott R. Breining"'
Autor:
Heemstra Ronald Joseph, J. Pike Mitchener, Gary Maurice Dull, Melvin Matt S, Cuthbertson Timothy J, John Genus, Scott R. Breining, Daniel Yohannes
Publikováno v:
Organic Process Research & Development. 17:413-421
The process research and development of two syntheses of a novel nicotinic partial agonist, TC-8817 ((+)-5), are described. The original Medicinal Chemistry route had multiple flaws, making it unsu...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8f2f9c464ab2fa9fc0191dca733f6fb
https://doi.org/10.1021/op400002r
https://doi.org/10.1021/op400002r
Publikováno v:
Tetrahedron. 53:8941-8962
A tandem cyclopropyliminium ion rearrangement-Hofmann elimination affords rapid access to 3-vinyl Δ2-pyrrolines in some cases bearing an unsaturated tether in good yield. The resulting dienamines subsequently undergo both inter- and intramolecular [
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bee0be75905253b2bae1dcb6c14e60a5
https://doi.org/10.1016/s0040-4020(97)90402-6
https://doi.org/10.1016/s0040-4020(97)90402-6
Autor:
Terry Hauser, Joseph Chewning, Vladimir P. Grinevich, Melvin Matt S, Fedorov Nikolai, David C. Kombo, Scott R. Breining, Kartik Tallapragada, Serguei S. Sidach, Miller Craig H, Jon-Paul Strachan
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(5)
We have carried out a pharmacological evaluation of arylmethylene quinuclidine derivatives interactions with human α3β4 nAChRs subtype, using cell-based receptor binding, calcium-influx, electrophysiological patch-clamp assays and molecular modelin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76a23f39515ef8827565070f285ee4cf
https://pubmed.ncbi.nlm.nih.gov/23352509
https://pubmed.ncbi.nlm.nih.gov/23352509
Autor:
Daniel Yohannes, Charles R. Wageman, Sheri McKinney, Michael J. Marks, Fedorov Nikolai, Paul Whiteaker, Scott R. Breining, Ryan M. Drenan, Sharon R. Grady, Henry A. Lester, Merouane Bencherif
Mammalian brain expresses multiple nicotinic acetylcholine receptor (nAChR) subtypes that differ in subunit composition, sites of expression and pharmacological and functional properties. Among known subtypes of receptors, alpha 4 beta 2* and alpha 6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2795bdbaf9b2dbfe2f4ac6e00bf954ee
https://resolver.caltech.edu/CaltechAUTHORS:20100604-114525877
https://resolver.caltech.edu/CaltechAUTHORS:20100604-114525877
Autor:
Paul Whiteaker, Charles R. Wageman, Sharon R. Grady, Michael J. Marks, Daniel Yohannes, Scott R. Breining, Merouane Bencherif, Henry A. Lester
Direct comparison of pyridine versus pyrimidine substituents on a small but diverse set of ligands indicates that the pyrimidine substitution has the potential to enhance affinity and/or functional activity at alpha6 subunit-containing neuronal nicot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c2c272c138358502899897498c80c98
https://europepmc.org/articles/PMC6107347/
https://europepmc.org/articles/PMC6107347/
Autor:
Miller Craig H, William S. Caldwell, Bhatti Balwinder Singh, Peter A. Crooks, Cynthia S. Day, Jon-Paul Strachan, Scott R. Breining, Niranjan Madhukar Deo, Persida Tahiri
Publikováno v:
The Journal of organic chemistry. 73(9)
In an attempt to generate nicotinic acetylcholine receptor (nAChR) ligands selective for the alpha4beta2 and alpha7 subtype receptors we designed and synthesized constrained versions of anabasine, a naturally occurring nAChR ligand. 2-(Pyridin-3-yl)-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6682cc68f2b68064b8dda9b4395ea4a2
https://pubmed.ncbi.nlm.nih.gov/18363376
https://pubmed.ncbi.nlm.nih.gov/18363376
Autor:
Scott R. Breining
Publikováno v:
ChemInform. 35
The extraordinary pharmacology of nicotine and epibatidine have indicated the potential for nicotinic acetylcholine receptor (nAChR) ligands to serve as a new therapeutic class for a host of CNS disorders. Many such ligands are natural products, or a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4ea69a1bf20eab9e94397d32fae91ae
https://doi.org/10.1002/chin.200438261
https://doi.org/10.1002/chin.200438261
Autor:
Daniel Yohannes, Maryka Quik, Scott R. Breining, Christopher D. Hepler, Paul Whiteaker, Sharon R. Grady
Publikováno v:
Biochemical Pharmacology. 82:1024
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e18e213081a2a9a00a69fbab262d8ffd
https://doi.org/10.1016/j.bcp.2011.07.006
https://doi.org/10.1016/j.bcp.2011.07.006