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of 17
pro vyhledávání: '"Scott R Welak"'
Autor:
Scott R Welak, Rebecca M Rentea, Ru-Jeng Teng, Nathan Heinzerling, Ben Biesterveld, Jennifer L Liedel, Kirkwood A Pritchard, Katherine M Fredrich, David M Gourlay
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e115317 (2014)
Necrotizing enterocolitis (NEC) is a complication of prematurity. The etiology is unknown, but is related to enteral feeding, ischemia, infection, and inflammation. Reactive oxygen species production, most notably superoxide, increases in NEC. NADPH
Externí odkaz:
https://doaj.org/article/3458505552a045b890513cdfa5fc0027
Publikováno v:
Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition. 33(4)
Necrotizing enterocolitis (NEC) is one of the most significant causes of morbidity and mortality among premature infants. The exact cause is considered multifactorial and related to gastrointestinal immaturity, inflammation and enteral feeding. The r
Publikováno v:
Journal of Biological Chemistry. 290:5449-5461
Sepsis-mediated endothelial Angiopoeitin-2 (Ang2) signaling may contribute to microvascular remodeling in the developing lung. The mechanisms by which bacterial cell wall components such as LPS mediate Ang2 signaling in human pulmonary microvascular
Autor:
Xiaoxia Li, Venkatesh Sampath, Alain Cuna, Heather Menden, Scott R. Welak, Shahid Umar, Jason Fawley, Steven J. McElroy, David M. Gourlay
Publikováno v:
Pediatric research. 83(1-1)
BackgroundThe mechanisms underlying aberrant activation of intestinal Toll-like receptor 4 (TLR4) signaling in necrotizing enterocolitis (NEC) remain unclear. In this study, we examined the role of single-immunoglobulin interleukin-1 receptor-related
Autor:
David M. Gourlay, Scott R. Welak, Ben E. Biesterveld, Jennifer L. Liedel, Kirkwood A. Pritchard, Nathan P. Heinzerling, Katherine Fredrich
Publikováno v:
Journal of Pediatric Surgery. 49:954-960
Background Necrotizing enterocolitis (NEC) is the most common surgical emergency in neonates, with a mortality rate between 10 and 50%. The onset of necrotizing enterocolitis is highly variable and associated with numerous risk factors. Prior researc
Autor:
Kevin M. Riggle, David M. Gourlay, Keith T. Oldham, Scott R. Welak, Kirkwood A. Pritchard, Rebecca M. Rentea
Publikováno v:
Journal of Surgical Research. 180:21-26
Background Necrotizing enterocolitis (NEC) is the most common surgical emergency in neonates, with an incidence of 0.5–2.4 cases per 1000 live births and a mortality rate between 10% and 50%. Neonates affected by NEC develop a septic injury that is
Autor:
Jennifer L. Liedel, Scott R. Welak, Deborah L. Donohoe, David M. Gourlay, Kirkwood A. Pritchard, Rebecca M. Rentea, Katherine Fredrich, Keith T. Oldham
Publikováno v:
European Journal of Pediatric Surgery. 23:039-047
Introduction Inflammation in the premature intestine is a key factor that leads to the development of necrotizing enterocolitis (NEC). Activation of nuclear factor kappa B (NF-κB) and subsequent inflammation increases the severity of NEC. The aim of
Autor:
Jennifer L. Liedel, Kirkwood A. Pritchard, Rebecca M. Rentea, Scott R. Welak, Pippa Simpson, David M. Gourlay, Keith T. Oldham, Katherine Fredrich
Publikováno v:
Journal of Surgical Research. 177:228-234
Background Supplementation of intestinal alkaline phosphatase (IAP), an endogenous protein expressed in the intestines, decreases the severity of necrotizing enterocolitis (NEC)–associated intestinal injury and permeability. We hypothesized that IA
Autor:
Scott R. Welak, Alan N. Mayer, Kirkwood A. Pritchard, Keith T. Oldham, Rebecca M. Rentea, Jennifer L. Liedel, Laura D. Cassidy, David M. Gourlay
Publikováno v:
Journal of Pediatric Surgery. 47:1135-1142
Background Previously, we have shown that supplementation of intestinal alkaline phosphatase (IAP) decreased severity of necrotizing enterocolitis (NEC)–associated intestinal injury. We hypothesized that IAP administration is protective of intestin
Autor:
Scott R. Welak, Annie Eis, Tongju Guan, Ru-Jeng Teng, Girija G. Konduri, Jianhai Du, Yang Shi
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 302:L651-L663
Autophagy is a process for cells to degrade proteins or entire organelles to maintain a balance in the synthesis, degradation, and subsequent recycling of cellular products. Increased reactive oxygen species formation is known to induce autophagy. We