Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Scott R McKercher"'
Autor:
Eun-Gyung Cho, Jeffrey D Zaremba, Scott R McKercher, Maria Talantova, Shichun Tu, Eliezer Masliah, Shing Fai Chan, Nobuki Nakanishi, Alexey Terskikh, Stuart A Lipton
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e24027 (2011)
Human embryonic stem cells (hESCs) can potentially differentiate into any cell type, including dopaminergic neurons to treat Parkinson's disease (PD), but hyperproliferation and tumor formation must be avoided. Accordingly, we use myocyte enhancer fa
Externí odkaz:
https://doaj.org/article/53ba5c9a0de04197981d40a27e5ed34c
Autor:
Shing Fai Chan, Xiayu Huang, Scott R. McKercher, Rameez Zaidi, Shu-ichi Okamoto, Nobuki Nakanishi, Stuart A. Lipton
Publikováno v:
Genomics Data, Vol 3, Iss C, Pp 24-27 (2015)
The myocyte enhancer factor 2 (MEF2) family of transcription factors is highly expressed in the brain and constitutes a key determinant of neuronal survival, differentiation, and synaptic plasticity. However, genome-wide transcriptional profiling of
Externí odkaz:
https://doaj.org/article/73e8eb511c4f452183a4c921aa1f0c04
Autor:
Chang-ki Oh, Tomohiro Nakamura, Nathan Beutler, Xu Zhang, Juan Piña-Crespo, Maria Talantova, Swagata Ghatak, Dorit Trudler, Lauren N. Carnevale, Scott R. McKercher, Malina A. Bakowski, Jolene K. Diedrich, Amanda J. Roberts, Ashley K. Woods, Victor Chi, Anil K. Gupta, Mia A. Rosenfeld, Fiona L. Kearns, Lorenzo Casalino, Namir Shaabani, Hejun Liu, Ian A. Wilson, Rommie E. Amaro, Dennis R. Burton, John R. Yates, Cyrus Becker, Thomas F. Rogers, Arnab K. Chatterjee, Stuart A. Lipton
Publikováno v:
Nat Chem Biol
bioRxiv
Nature chemical biology, vol 19, iss 3
bioRxiv
Nature chemical biology, vol 19, iss 3
Prevention of infection and propagation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a high priority in the Coronavirus Disease 2019 (COVID-19) pandemic. Here we describe S-nitrosylation of multiple proteins involved in SARS-CoV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c56dbbfbb07a25bd2fb1950e211865c3
https://europepmc.org/articles/PMC10127945/
https://europepmc.org/articles/PMC10127945/
Publikováno v:
Annual Review of Pharmacology and Toxicology. 61:701-721
Excitatory/inhibitory (E/I) balance, defined as the balance between excitation and inhibition of synaptic activity in a neuronal network, accounts in part for the normal functioning of the brain, controlling, for example, normal spike rate. In many p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a87b962f7bef21dc1738ebebcae7b76b
https://doi.org/10.1146/annurev-pharmtox-032320-015420
https://doi.org/10.1146/annurev-pharmtox-032320-015420
Autor:
Chang-ki Oh, Tomohiro Nakamura, Nathan Beutler, Xu Zhang, Juan Piña-Crespo, Maria Talantova, Swagata Ghatak, Dorit Trudler, Lauren N. Carnevale, Scott R. McKercher, Malina A. Bakowski, Jolene K. Diedrich, Amanda J. Roberts, Ashley K. Woods, Victor Chi, Anil K. Gupta, Mia A. Rosenfeld, Fiona L. Kearns, Lorenzo Casalino, Namir Shaabani, Hejun Liu, Ian A. Wilson, Rommie E. Amaro, Dennis R. Burton, John R. Yates, Cyrus Becker, Thomas F. Rogers, Arnab K. Chatterjee, Stuart A. Lipton
Prevention of infection and propagation of SARS-CoV-2 is of high priority in the COVID-19 pandemic. Here, we describe S-nitrosylation of multiple proteins involved in SARS-CoV-2 infection, including angiotensin converting enzyme 2 (ACE2), the recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58752c9c933d0e60be78b4110ba8ac35
https://doi.org/10.1101/2022.04.05.487060
https://doi.org/10.1101/2022.04.05.487060
Autor:
Takumi Satoh, Romain Stalder, Scott R. McKercher, Robert E. Williamson, Gregory P. Roth, Stuart A. Lipton
Publikováno v:
ASN Neuro, Vol 7 (2015)
Activation of the Kelch-like ECH-associated protein 1/nuclear factor (erythroid-derived 2)-like 2 and heat-shock protein 90/heat-shock factor-1 signal-transduction pathways plays a central role in combatting cellular oxidative damage and related endo
Externí odkaz:
https://doaj.org/article/6df3e9a0b37f424eb887b8d783eaf62f
Autor:
Matthew E. Albertolle, Scott R. McKercher, Stuart A. Lipton, Abdullah Sultan, Henry R. Scott, Tomohiro Nakamura, Amanda K. Deal, Harry Ischiropoulos, Paschalis-Thomas Doulias
Publikováno v:
J Neurovirol
Journal of neurovirology, vol 27, iss 3
Journal of neurovirology, vol 27, iss 3
In the brain, both HIV-1 and methamphetamine (meth) use result in increases in oxidative and nitrosative stress. This redox stress is thought to contribute to the pathogenesis of HIV-associated neurocognitive disorder (HAND) and further worsening cog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a8c6265ebd0077a10adfdbb9d5b5bbd
https://europepmc.org/articles/PMC8477648/
https://europepmc.org/articles/PMC8477648/
Autor:
Walid Soussou, Stuart A. Lipton, Scott R. McKercher, Sara Sanz-Blasco, Nima Dolatabadi, Mohd Waseem Akhtar, Rajesh Ambasudhan, Michelle S. Lee, James C. Parker, Tomohiro Nakamura, Kevin Chon
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Nature communications, vol 7, iss 1
Nature Communications
Nature communications, vol 7, iss 1
Nature Communications
Metabolic syndrome (MetS) and Type 2 diabetes mellitus (T2DM) increase risk for Alzheimer's disease (AD). The molecular mechanism for this association remains poorly defined. Here we report in human and rodent tissues that elevated glucose, as found
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b44636981518c2dc81fc14768a0bb6a3
https://doaj.org/article/9fb0c0af61564f9ba2f975e9d457f235
https://doaj.org/article/9fb0c0af61564f9ba2f975e9d457f235
Autor:
Scott R. McKercher, Tomohiro Nakamura, Rajesh Ambasudhan, Saumya Nagar, Stuart A. Lipton, Shu-ichi Okamoto, Elaine Pirie, Olga Prikhodko, Chang-ki Oh, Mohd Waseem Akhtar
Publikováno v:
Neurobiology of Disease, Vol 84, Iss, Pp 99-108 (2015)
Nitric oxide (NO) is a gasotransmitter that impacts fundamental aspects of neuronal function in large measure through S-nitrosylation, a redox reaction that occurs on regulatory cysteine thiol groups. For instance, S-nitrosylation regulates enzymatic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14d07176366496027daccd3c47cd226d
https://doi.org/10.1016/j.nbd.2015.03.017
https://doi.org/10.1016/j.nbd.2015.03.017
Autor:
Shichun Tu, Eliezer Masliah, Nobuki Nakanishi, Scott R. McKercher, Stuart A. Lipton, Yeon-Joo Kang
Publikováno v:
Journal of Molecular Neuroscience. 58:59-65
HIV-associated neurocognitive disorder (HAND) consists of motor and cognitive dysfunction in a relatively large percentage of patients with AIDS. Prior work has suggested that at least part of the neuronal and synaptic damage observed in HAND may occ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37e6ab2634dbb96239b39a334922e18b
https://doi.org/10.1007/s12031-015-0651-1
https://doi.org/10.1007/s12031-015-0651-1