Genetic mechanisms control the linear scaling between related cortical primary and higher order sensory areas

Autor: Andreas Zembrzycki, Adam M Stocker, Axel Leingärtner, Setsuko Sahara, Shen-Ju Chou, Valery Kalatsky, Scott R May, Michael P Stryker, Dennis DM O'Leary

Publikováno v: eLife, Vol 4 (2015)

In mammals, the neocortical layout consists of few modality-specific primary sensory areas and a multitude of higher order ones. Abnormal layout of cortical areas may disrupt sensory function and behavior. Developmental genetic mechanisms specify pri

Externí odkaz: https://doaj.org/article/9750d567fbd149fabaf6691a6293c00a

A focused and efficient genetic screening strategy in the mouse: identification of mutations that disrupt cortical development.

Autor: Konstantinos Zarbalis, Scott R May, Yiguo Shen, Marc Ekker, John L R Rubenstein, Andrew S Peterson

Publikováno v: PLoS Biology, Vol 2, Iss 8, p E219 (2004)

Although the mechanisms that regulate development of the cerebral cortex have begun to emerge, in large part through the analysis of mutant mice (Boncinelli et al. 2000; Molnar and Hannan 2000; Walsh and Goffinet 2000), many questions remain unanswer

Externí odkaz: https://doaj.org/article/191753812dd14c8ebf97a223131dcba8

Genetic mechanisms control the linear scaling between related cortical primary and higher order sensory areas

Autor: Setsuko Sahara, Andreas Zembrzycki, Shen-Ju Chou, Michael P. Stryker, Adam M. Stocker, Axel Leingärtner, Dennis D.M. O'Leary, Valery A. Kalatsky, Scott R. May

Publikováno v: eLife, Vol 4 (2015)
Zembrzycki, A, Stocker, A, Leingärtner, A, Sahara, S, Chou, S-J, Kalatsky, V, May, S, Stryker, M & O'Leary, D DM 2015, ' Genetic mechanisms control the linear scaling between related cortical primary and higher order sensory areas. ', eLife, vol. 4, no. 0, e11416 . https://doi.org/10.7554/eLife.11416
eLife

In mammals, the neocortical layout consists of few modality-specific primary sensory areas and a multitude of higher order ones. Abnormal layout of cortical areas may disrupt sensory function and behavior. Developmental genetic mechanisms specify pri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a5dd66348b91438803a7e9d02e0bec6
https://elifesciences.org/articles/11416

Cortical dysplasia and skull defects in mice with a Foxc1 allele reveal the role of meningeal differentiation in regulating cortical development

Autor: Youngshik Choe, Konstantinos Zarbalis, Julie A. Siegenthaler, Scott R. May, Samuel J. Pleasure, Andrew S. Peterson

Publikováno v: Proceedings of the National Academy of Sciences. 104:14002-14007

We report the identification of a hypomorphic mouse allele for Foxc1 ( Foxc1 hith ) that survives into adulthood revealing previously unknown roles for Foxc1 in development of the skull and cerebral cortex. This line of mice was recovered in a forwar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::689e7f3fff06832ea022947440b06b90
https://doi.org/10.1073/pnas.0702618104

Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli

Autor: Andrew S. Peterson, Jeremy F. Reiter, Baolin Wang, Mattias Karlen, Konstantinos Zarbalis, Yiguo Shen, Scott R. May, Johan Ericson, Amir M. Ashique

Publikováno v: Developmental Biology. 287:378-389

Sonic Hedgehog (Shh) signals are transduced into nuclear ratios of Gli transcriptional activator versus repressor. The initial part of this process is accomplished by Shh acting through Patched (Ptc) to regulate Smoothened (Smo) activity. The mechani

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed21d12186964a5b7621b4dc29ec574a
https://doi.org/10.1016/j.ydbio.2005.08.050