Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Scott R Armstrong"'
Autor:
David T Beattie, Scott R Armstrong, Ross G Vickery, Pam eTsuruda, Christina B Campbell, Carrie eRichardson, Julia eMcCullough, Oranee eDaniels, Kathryn eKersey, Yu-Ping eLi, Karl HS Kim
Publikováno v:
Frontiers in Pharmacology, Vol 2 (2011)
This study evaluated the in vitro and in vivo pharmacological properties of TD-8954, a potent and selective 5-HT4 receptor agonist. TD-8954 had high affinity (pKi = 9.4) for human recombinant 5-HT4(c) (h5-HT4(c)) receptors, and selectivity (> 2,000-f
Externí odkaz:
https://doaj.org/article/8b74fc1b5c7847d09963708f3ff40836
OBJECTIVE: To identify the class of evidence for aducanumab use for the treatment of Alzheimer disease and present clinical considerations regarding use. METHODS: The author panel systematically reviewed available clinical trial data detailing aducan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2127::5798f5be69723eeed5ff730066d60e08
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3213667
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3213667
Autor:
David Beattie, Jacobsen John R, Glenmar P. Obedencio, Scott R. Armstrong, Timothy J. Church, Daniel D. Long, Ross G. Vickery, Pamela R. Tsuruda, Pierre-Jean Colson, Christina B. Campbell, Stergiades Ioanna, Miroslav Rapta, Dalziel Sean M, Daisuke Saito, Priscilla Van Dyke, Lan Jiang
Publikováno v:
ACS Med Chem Lett
[Image: see text] The effects of opioids in the central nervous system (CNS) provide significant benefit in the treatment of pain but can also lead to physical dependence and addiction, which has contributed to a growing opioid epidemic in the United
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05eb2998f1bc2f55f8f113199e7df461
https://europepmc.org/articles/PMC6912869/
https://europepmc.org/articles/PMC6912869/
Autor:
Ariel M. Wilson, Taner Dogan, Dan Marquess, Agnieszka Dejda, Pedro J. Beltran, Przemyslaw Sapieha, Rachel Juneau, Rathi D. Ryan, Frédérick A. Mallette, Gabrielle Girouard, Scott R. Armstrong, Vera Guber, Christian Beauséjour, Frédérique Pilon, Priyanka Patel, Frederik Fournier, Alexandre Dubrac, Sonali Dasgupta, Manuel Buscarlet, Sergio Crespo-Garcia, Surabhi R. Rao, Shawnta Y. Chaney, Christopher B. Yohn, Robert O’Brien, Gael Cagnone, Jean-Sebastien Joyal, Pamela R. Tsuruda
Publikováno v:
Cell Metabolism. 33:818-832.e7
Attenuating pathological angiogenesis in diseases characterized by neovascularization such as diabetic retinopathy has transformed standards of care. Yet little is known about the molecular signatures discriminating physiological blood vessels from t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::724992eebc54ca734985ab51ac6e1db9
https://doi.org/10.1016/j.cmet.2021.01.011
https://doi.org/10.1016/j.cmet.2021.01.011
Autor:
Jeng-Pyng Shaw, Daniel Marquess, R. Murray McKinnell, Paul R. Fatheree, David Beattie, Scott R. Armstrong, Daniel D. Long, Ross G. Vickery
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:4210-4215
The discovery of a series of 5-HT4 receptor agonists based on a novel 2-alkylbenzimidazole aromatic core is described. Optimization of the 2-substituent of the benzimidazole ring led to a series of agonists with subnanomolar binding affinity and mode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0643983a830ed44b26b2d665107333f
https://doi.org/10.1016/j.bmcl.2013.05.018
https://doi.org/10.1016/j.bmcl.2013.05.018
Autor:
Daniel D. Long, Scott R. Armstrong, David Beattie, Carrie Richardson, Sharath S. Hegde, Christina B. Campbell, Ross G. Vickery, Pamela R. Tsuruda
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 386:471-478
The in vivo preclinical pharmacodynamic profile of TD-1211, a selective opioid receptor antagonist currently under development for the treatment of opioid-induced constipation, was compared to that of the clinically studied opioid antagonists, naltre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d67dda43c21d81ff8abfbc1c7827bc1e
https://doi.org/10.1007/s00210-013-0844-5
https://doi.org/10.1007/s00210-013-0844-5
Autor:
Patrick P.A. Humphrey, J A M Smith, D. Marquess, J. A. Taylor, C. Sandlund, J.-P. Shaw, David Beattie, Scott R. Armstrong
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 378:139-147
The in vivo preclinical pharmacodynamic profile of TD-5108, a selective 5-HT4 receptor agonist with high intrinsic activity, was compared to that of the clinically studied gastrointestinal pro-kinetic agents, tegaserod, cisapride and mosapride. The a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8a47fa50a10c4201658fcf83cb3d47a
https://doi.org/10.1007/s00210-008-0281-z
https://doi.org/10.1007/s00210-008-0281-z
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 53:198-205
Introduction In vitro studies have demonstrated a 5-HT4 receptor-mediated relaxation of the pre-contracted rat esophagus. However, it is unclear whether 5-HT4 receptor agonists affect resting esophageal tone in vivo. The activity of 5-HT and several
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f41aa84772dec4b4a4ef36d8fb312be3
https://doi.org/10.1016/j.vascn.2005.08.004
https://doi.org/10.1016/j.vascn.2005.08.004
Autor:
Paul R. Fatheree, Jacqueline A.M. Smith, Patrick P. Humphrey, David Beattie, S. Derek Turner, Seok-Ki Choi, Roland Gendron, Daniel Marquess, Goldblum Adam A, Ross G. Vickery, Jeng Pyng Shaw, Scott R. Armstrong, Daniel D. Long, Lan Jiang, Daniel Genov
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(19)
Utilization of Theravance’s multivalent approach to drug discovery towards 5-HT 4 receptor agonists with a focus on identification of neutral (non-charged at physiological pH) secondary binding groups is described. Optimization of a quinolone-tropa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98dc3bfd1562242be0ff583154f8c9fe
https://pubmed.ncbi.nlm.nih.gov/22959244
https://pubmed.ncbi.nlm.nih.gov/22959244
Autor:
David Beattie, Daniel D. Long, S. Derek Turner, Paul R. Fatheree, Jacqueline A.M. Smith, Scott R. Armstrong, Seok-Ki Choi, Roland Gendron, Jeng Pyng Shaw, Goldblum Adam A, Daniel Marquess, Ross G. Vickery, Patrick P. Humphrey
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(14)
Further application of our multivalent approach to drug discovery directed to 5-HT4 receptor agonists is described. Optimization of the linker and secondary binding amine in the indazole-tropane primary binding group series, for binding affinity and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91d91c6df1bb3ebe20770d405356021a
https://pubmed.ncbi.nlm.nih.gov/22683222
https://pubmed.ncbi.nlm.nih.gov/22683222