Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Scott Q Siler"'
Autor:
Jeffrey L Woodhead, Kyunghee eYang, Scott Q Siler, Paul Brent Watkins, Kim L.R. Brouwer, Hugh A Barton, Brett A Howell
Publikováno v:
Frontiers in Pharmacology, Vol 5 (2014)
Inhibition of the bile salt export pump (BSEP) has been linked to incidence of drug-induced liver injury (DILI), presumably by the accumulation of toxic bile acids in the liver. We have previously constructed and validated a model of bile acid dispos
Externí odkaz:
https://doaj.org/article/64259af463dc478a95f0ad84590ccafa
Autor:
James J. Beaudoin, Kyunghee Yang, Jeffry Adiwidjaja, Guncha Taneja, Paul B. Watkins, Scott Q. Siler, Brett A. Howell, Jeffrey L. Woodhead
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2023)
Inhibition of the canalicular phospholipid floppase multidrug resistance protein 3 (MDR3) has been implicated in cholestatic drug-induced liver injury (DILI), which is clinically characterized by disrupted bile flow and damage to the biliary epitheli
Externí odkaz:
https://doaj.org/article/854fa12f4fac4c6c81044b54a6766df4
Autor:
Grant Generaux, Vinal V. Lakhani, Yuching Yang, Sashi Nadanaciva, Luping Qiu, Keith Riccardi, Li Di, Brett A. Howell, Scott Q. Siler, Paul B. Watkins, Hugh A. Barton, Michael D. Aleo, Lisl K. M. Shoda
Publikováno v:
Pharmacology Research & Perspectives, Vol 7, Iss 6, Pp n/a-n/a (2019)
Abstract Many compounds that appear promising in preclinical species, fail in human clinical trials due to safety concerns. The FDA has strongly encouraged the application of modeling in drug development to improve product safety. This study illustra
Externí odkaz:
https://doaj.org/article/828b1d4c830842609ef4d255b6b2b62b
Autor:
Yang, James J. Beaudoin, Lara Clemens, Mark T. Miedel, Albert Gough, Fatima Zaidi, Priya Ramamoorthy, Kari E. Wong, Rangaprasad Sarangarajan, Christina Battista, Lisl K. M. Shoda, Scott Q. Siler, D. Lansing Taylor, Brett A. Howell, Lawrence A. Vernetti, Kyunghee
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 11; Pages: 9692
Biologics address a range of unmet clinical needs, but the occurrence of biologics-induced liver injury remains a major challenge. Development of cimaglermin alfa (GGF2) was terminated due to transient elevations in serum aminotransferases and total
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::f5d2d21d59cdb846ddbe216b495d7438
Autor:
William A. Murphy, Jeffry Adiwidjaja, Noora Sjöstedt, Kyunghee Yang, James J. Beaudoin, Jessica Spires, Scott Q. Siler, Sibylle Neuhoff, Kim L.R. Brouwer
Publikováno v:
Clinical Pharmacology & Therapeutics. 113:275-297
Nonalcoholic fatty liver disease (NAFLD), representing a clinical spectrum ranging from nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH), is rapidly evolving into a global pandemic. Patients with NAFLD are burdened with high rat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db0f95ca9338677680f2628feda23b53
https://doi.org/10.1002/cpt.2614
https://doi.org/10.1002/cpt.2614
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 188(1)
Calcitonin gene-related peptide (CGRP) signaling inhibitors have shown efficacy in both the acute and preventive treatment of migraine. Telcagepant, a first-generation CGRP receptor antagonist, was effective but failed in clinical trials due to hepat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa987be0696be48efef7224cc2a9008d
https://pubmed.ncbi.nlm.nih.gov/35556143
https://pubmed.ncbi.nlm.nih.gov/35556143
Publikováno v:
Journal of Lipid Research, Vol 39, Iss 12, Pp 2319-2328 (1998)
We used [2-13C1]glycerol to characterize very low density lipoprotein (VLDL)-triglyceride kinetics and intrahepatic glycerol metabolism in normal men (n = 4) after alcohol (EtOH) ingestion. [2-13C1]glycerol was infused before and after the consumptio
Externí odkaz:
https://doaj.org/article/22185f040caf4859ac6c394fb6ad24a3
Autor:
Simone H. Stahl, Christina Battista, Paul B. Watkins, Scott Q. Siler, Jerome T. Mettetal, Kyunghee Yang, Brett A. Howell
Publikováno v:
Toxicological Sciences
CKA, a chemokine receptor antagonist intended for treating inflammatory conditions, produced dose-dependent hepatotoxicity in rats but advanced into the clinic where single doses of CKA up to 600 mg appeared safe in humans. Because existing toxicolog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b978f96547347f1557add929a62dd55e
https://doi.org/10.1093/toxsci/kfy191
https://doi.org/10.1093/toxsci/kfy191
Autor:
Mathias Wind, Paul B. Watkins, Martina Maurer, Marc Engelhardt, Simon Messner, Anne Schmitt-Hoffmann, Jochen Spickermann, Franziska Paech, Jeffrey L. Woodhead, Anne-Therese Witschi, Brett A. Howell, Scott Q. Siler, Stephan Krähenbühl
Publikováno v:
Clinical and Translational Science. 11:498-505
Elevations of liver enzymes have been observed in clinical trials with BAL30072, a novel antibiotic. In vitro assays have identified potential mechanisms for the observed hepatotoxicity, including electron transport chain (ETC) inhibition and reactiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fca62afdc992a3b97a30d486c944b62
https://doi.org/10.1111/cts.12560
https://doi.org/10.1111/cts.12560
Autor:
Yoo Sik Shim, Jonathan E. McDunn, Andrey P. Tikunov, Paul B. Watkins, Narayan Bhattarai, Edward L. LeCluyse, Scott Q. Siler, Valerie Y. Soldatow, Jeffrey M. Macdonald
Publikováno v:
Toxicology in Vitro. 45:119-127
Real-time dose-response curves for fructose have been non-invasively determined in primary rat hepatocyte alginate spheroids cultured in a NMR-compatible fluidized-bed bioreactor. Using 13C-labeled glucose and glycine culture medium, fructose dose wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4c18e6f5b5605500ebf99a695d6f7c3
https://doi.org/10.1016/j.tiv.2017.08.021
https://doi.org/10.1016/j.tiv.2017.08.021