Serotonin-induced vascular permeability is mediated by transient receptor potential vanilloid 4 in the airways and upper gastrointestinal tract of mice

Autor: Sadia Alvi, Daniel P. Poole, Peter McIntyre, Scott Peng, Arisbel B. Gondin, Paulina D. Ramírez-García, Pradeep Rajasekhar, Larissa K. Dill, Simona E. Carbone, Thomas P. Davis, Felix Bennetts, Jeffri S. Retamal, Megan S. Grace, Juhura G. Almazi, Nicholas A. Veldhuis, Nigel W. Bunnett

Publikováno v: Laboratory Investigation; a Journal of Technical Methods and Pathology

Endothelial and epithelial cells form physical barriers that modulate the exchange of fluid and molecules. The integrity of these barriers can be influenced by signaling through G protein-coupled receptors (GPCRs) and ion channels. Serotonin (5-HT) i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::352f5148f2234e1e018f3f3c63eb5cb6
https://doi.org/10.1038/s41374-021-00593-7

Towards comprehensive understanding of bacterial genetic diversity: large-scale amplifications in Bordetella pertussis and Mycobacterium tuberculosis

Autor: Jonathan S. Abrahams, Michael R. Weigand, Natalie Ring, Iain MacArthur, Joss Etty, Scott Peng, Margaret M. Williams, Barret Bready, Anthony P. Catalano, Jennifer R. Davis, Michael D. Kaiser, John S. Oliver, Jay M. Sage, Stefan Bagby, M. Lucia Tondella, Andrew R. Gorringe, Andrew Preston

Publikováno v: Abrahams, J S, Weigand, M R, Ring, N, Macarthur, I, Etty, J, Peng, S, Williams, M M, Bready, B, Catalano, A P, Davis, J R, Kaiser, M D, Oliver, J S, Sage, J M, Bagby, S, Tondella, M L, Gorringe, A R & Preston, A 2022, ' Towards comprehensive understanding of bacterial genetic diversity : large-scale amplifications in Bordetella pertussis and Mycobacterium tuberculosis ', Microbial Genomics, vol. 8, no. 2, 000761 . https://doi.org/10.1099/mgen.0.000761

Bacterial genetic diversity is often described solely using base-pair changes despite a wide variety of other mutation types likely being major contributors. Tandem duplication/amplifications are thought to be widespread among bacteria but due to the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e3dea56f553da65c245d4ef81247d75
https://doi.org/10.1099/mgen.0.000761

The transient receptor potential vanilloid 4 (TRPV4) ion channel mediates protease activated receptor 1 (PAR1)-induced vascular hyperpermeability

Autor: Daniel P. Poole, Thomas P. Davis, William Darby, Tara Tigani, Nigel W. Bunnett, Scott Peng, Peter McIntyre, Larissa K. Dill, Nicholas A. Veldhuis, Jeffri S. Retamal, Arisbel B. Gondin, Simona E. Carbone, Fe C. Abogadie, Megan S. Grace

Publikováno v: Lab Invest

Endothelial barrier disruption is a hallmark of tissue injury, edema, and inflammation. Vascular endothelial cells express the G protein-coupled receptor (GPCR) protease acctivated receptor 1 (PAR1) and the ion channel transient receptor potential va

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::364e5279eaaa0ad30092b48ecc6e66ed
https://europepmc.org/articles/PMC10080476/

Mini-review: Dissecting receptor-mediated stimulation of TRPV4 in nociceptive and inflammatory pathways

Autor: Daniel P. Poole, Nicholas A. Veldhuis, Scott Peng

Publikováno v: Neuroscience Letters. 770:136377

Transient Receptor Potential Vanilloid 4 (TRPV4) is a polymodal, non-selective cation channel that detects thermal, mechanical, and environmental cues and contributes to a range of diverse physiological processes. The effects of chronic TRPV4 stimula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28cb63f3a7e4ed41ab46a253c2075516
https://doi.org/10.1016/j.neulet.2021.136377