Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Scott P. Runyon"'
Autor:
Shaobin Wang, Scott P. Runyon, Lucas Laudermilk, Vineetha Vasukuttan, Ravi Kumar Vyas Devambatla, Rangan Maitra, Sanju Narayanan, Rodney W. Snyder, Chunyang Jin, Donghua Dai
Publikováno v:
Journal of Medicinal Chemistry. 64:3006-3025
Apelin receptor agonism improves symptoms of metabolic syndrome. However, endogenous apelin peptides have short half-lives, making their utility as potential drugs limited. Previously, we had identified a novel pyrazole-based agonist scaffold. System
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d5d7e817b7c96901ff8294278468b4f
https://doi.org/10.1021/acs.jmedchem.0c01448
https://doi.org/10.1021/acs.jmedchem.0c01448
Autor:
Sanju Narayanan, Donghua Dai, Ravi Kumar Vyas Devambatla, Vincent Albert, Nicolas Bruneau-Latour, Vineetha Vasukuttan, Stephane Ciblat, Kenneth Rehder, Scott P. Runyon, Rangan Maitra
Publikováno v:
Bioorganicmedicinal chemistry. 66
The apelin receptor (APJ) is a target for cardiovascular indications. Previously, we had identified a novel pyrazole-based agonist 1 ((S)-N-(1-(cyclobutylamino)-1-oxo-5-(piperidin-1-yl)pentan-3-yl)-1-cyclopentyl-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80783d395f380d013113468cb94c1424
https://pubmed.ncbi.nlm.nih.gov/35594649
https://pubmed.ncbi.nlm.nih.gov/35594649
Autor:
Scott P. Runyon, Adele.E. Queen, Desong Zhong, David Hesk, David M. Lindsay, William J. Kerr, Timothy R. Fennell, Wayne Mascarella, Kenneth S. Rehder
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 63:196-202
[3 H]Genipin was synthesized in a single step by Ir(I) catalyzed hydrogen isotope exchange. Conditions for selective exchange of the sp2 CH bond ortho to the methyl ester functionality were developed through deuterium modeling studies through a catal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a0283f6e7cf473fa399212c4113fd94
https://doi.org/10.1002/jlcr.3832
https://doi.org/10.1002/jlcr.3832
Autor:
Carly Baehr, Christine Robinson, Andrew Kassick, Rajwana Jahan, Valeria Gradinati, Saadyah E. Averick, Scott P. Runyon, Marco Pravetoni
Publikováno v:
ACS omega. 7(19)
The ongoing public health emergency of opioid use disorders (OUD) and overdose in the United States is largely driven by fentanyl and its related analogues and has resulted in over 75 673 deaths in 2021. Immunotherapeutics such as vaccines have been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::621ed26d723470e4d1d6b36195839cd3
https://pubmed.ncbi.nlm.nih.gov/35601290
https://pubmed.ncbi.nlm.nih.gov/35601290
Autor:
Marina Kovaliov, Marco Pravetoni, Scott P. Runyon, Mark G. LeSage, Danni L. Harris, Sandra D. Comer, Saadyah Averick, Christine Robinson, Valeria Gradinati, Carly Baehr, Federico Baruffaldi, Bethany Crouse, Fatima Hamid
Publikováno v:
Journal of medicinal chemistry. 63(23)
The incidence of fatal overdoses has increased worldwide due to the widespread access to illicit fentanyl and its potent analogues. Vaccines offer a promising strategy to reduce the prevalence of opioid use disorders (OUDs) and to prevent toxicity fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29697e3f76a81223b8a2d2b8233ee0dd
https://pubmed.ncbi.nlm.nih.gov/33215913
https://pubmed.ncbi.nlm.nih.gov/33215913
Autor:
Bin Zhou, Sheryl S. Moy, Scott P. Runyon, Lucas Laudermilk, Kathryn M. Harper, Rangan Maitra, Beverly H. Koller
Publikováno v:
Behav Brain Res
The G-protein-coupled receptor APLNR and its ligands apelin and ELABELA/TODDLER/apela comprise the apelinergic system, a signaling pathway that is critical during development and physiological homeostasis. Targeted regulation of the receptor has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86f89aabb2ce44c391c32650f0ae80dc
https://pubmed.ncbi.nlm.nih.gov/33309737
https://pubmed.ncbi.nlm.nih.gov/33309737
Autor:
Ann M. Decker, S. Wayne Mascarella, Chad M. Kormos, Timothy R. Fennell, James B. Thomas, Scott P. Runyon, Rodney W. Snyder, Hernán A. Navarro, F. Ivy Carroll, Pauline W. Ondachi
Publikováno v:
Journal of Medicinal Chemistry. 61:7546-7559
Animal pharmacological studies suggest that potent and selective κ opioid receptor antagonists have potential as pharmacotherapies targeting depression, anxiety, and substance abuse (opiates, alcohol, nicotine, cocaine). We recently reported lead co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50fa2f6a33a02710ba7bb081d0dfb375
https://doi.org/10.1021/acs.jmedchem.8b00674
https://doi.org/10.1021/acs.jmedchem.8b00674
Autor:
Rangan Maitra, Timothy W. Lefever, Yanan Zhang, George S. Amato, Amruta Manke, Vineetha Vasukuttan, Scott P. Runyon, Danni L. Harris, Ricardo A. Cortes, Rodney W. Snyder, Shaobin Wang, Robert W. Wiethe
Publikováno v:
J Med Chem
Type 1 cannabinoid receptor (CB1) antagonists have demonstrated promise for the treatment of obesity, liver disease, metabolic syndrome, and dyslipidemias. However, the inhibition of CB1 receptors in the central nervous system can produce adverse eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9763d78d925acb5b8295efd945ae7d35
https://doi.org/10.1021/acs.jmedchem.7b01820
https://doi.org/10.1021/acs.jmedchem.7b01820
Autor:
Rodney W. Snyder, George S. Amato, Y Yueh, Robert W. Wiethe, Rangan Maitra, Ann M. Decker, Scott P. Runyon, Amruta Manke, Vineetha Vasukuttan
Publikováno v:
J Med Chem
Peripherally restricted CB1 receptor antagonists may be useful in treating metabolic syndrome, diabetes, liver diseases, and gastrointestinal disorders. Clinical development of the centrally acting CB1 inverse agonist otenabant (1) was halted due to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be946dcb30df8043c6eb2a16c36cf355
https://europepmc.org/articles/PMC7656562/
https://europepmc.org/articles/PMC7656562/
Autor:
Carla Hassler, Paul R. Pentel, Marco Pravetoni, Federico Baruffaldi, Frank I. Carroll, Michael D. Raleigh, Scott P. Runyon, S. J. King, S. Winston, Angela K. Birnbaum, Michaela J. Roslawski
Publikováno v:
Mol Pharm
This study focused on formulating conjugate vaccines targeting oxycodone and heroin for technology transfer, good manufacturing practice (GMP), and clinical evaluation. Lead vaccines used the highly immunogenic carrier protein keyhole limpet hemocyan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca15cf948cde855080b502b2c7f708d1
https://pubmed.ncbi.nlm.nih.gov/31018096
https://pubmed.ncbi.nlm.nih.gov/31018096