Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Scott P. Goulding"'
Autor:
Giovana C. Macedo, Max Kreifeldt, Scott P. Goulding, Agbonlahor Okhuarobo, Harpreet Sidhu, Candice Contet
Publikováno v:
Neuropsychopharmacology. 48:821-830
Alcohol use disorders can be driven by negative reinforcement. Alterations of the microtubule cytoskeleton have been associated with mood regulation in the context of depression. Notably, MAP4343, a pregnenolone derivative known to promote tubulin as
Autor:
Giordano de Guglielmo, Olivier George, Lieselot L. G. Carrette, Candice Contet, Scott P. Goulding
Publikováno v:
Alcohol Clin Exp Res
BACKGROUND. Chronic exposure to ethanol and other drugs of abuse can alter the expression and activity of cyclin-dependent kinase 5 (CDK5) and its cofactor p35, but the functional implication of CDK5 signaling in the regulation of ethanol-related beh
Autor:
Jared L. Dietze, Daniel A. Rothenberg, Terri A. Addona, Antoine Boudot, Jessica Kohler, Jennifer G. Abelin, Vikram R. Juneja, Paul J. Turcott, Brandon P. Conn, Marit M. van Buuren, Scott P. Goulding, Christopher D. McGann, Richard B. Gaynor, John R. Srouji, Kendra C. Foley, Jae Won Choi, Michael S. Rooney, Divya Lenkala
Publikováno v:
Cell Reports Methods. 1:100084
Summary Oncogenic mutations in KRAS can be recognized by T cells on specific class I human leukocyte antigen (HLA-I) molecules, leading to tumor control. To date, the discovery of T cell targets from KRAS mutations has relied on occasional T cell res
Autor:
Tod E. Kippin, Karen K. Szumlinski, Ryan S. Waltermire, Amy R. Williams, Michal A. Coelho, Kaziya M. Lee, Racquel D. Domingo, Rianne R. Campbell, Matthias Klugmann, Andrew B. Thompson, Adam T. Gould, Melissa G. Wroten, Paul F. Worley, Hadley A. McGregor, Sema G. Quadir, C. Leonardo Jimenez Chavez, Daniel I. Greentree, Scott P. Goulding, Georg von Jonquieres
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience, vol 39, iss 14
The bed nucleus of the stria terminalis (BNST) is part of the limbic-hypothalamic system important for behavioral responses to stress, and glutamate transmission within this region has been implicated in the neurobiology of alcoholism. Herein, we use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::586dab23704143db1908ecb8dacc5009
https://europepmc.org/articles/PMC6445984/
https://europepmc.org/articles/PMC6445984/
Autor:
Terri A. Addona, Christina M. Arieta, Richard B. Gaynor, Dewi Harjanto, Yusuf Nasrullah, Dominik Barthelme, Jeff Hammerbacher, Matthew Malloy, Edward F. Fritsch, Rob C. Oslund, Prerna Suri, Asaf Poran, Joel Greshock, Christopher D. McGann, Daniel A. Rothenberg, Sagar Chhangawala, Scott P. Goulding, Alex Rubinsteyn, Tyler Colson, Gibran Nasir, Amanda L. Creech, Ying S. Ting, Michael S. Rooney, Diana Velez, Jennifer G. Abelin, Lia R. Serrano
Publikováno v:
Immunity. 51(4)
Summary Increasing evidence indicates CD4+ T cells can recognize cancer-specific antigens and control tumor growth. However, it remains difficult to predict the antigens that will be presented by human leukocyte antigen class II molecules (HLA-II), h
Autor:
Vikram R. Juneja, Terri A. Addona, John Srouji, Jae Won Choi, Michael S. Rooney, Brandon P. Conn, Paul J. Turcott, Christopher D. McGann, Jennifer G. Abelin, Richard B. Gaynor, Antoine Boudot, Marit M. van Buuren, Scott P. Goulding, Jessica Kohler, Divya Lenkala, Daniel A. Rothenberg, Jared L. Dietze
Publikováno v:
Cancer Research. 80:PO-015
Response rates to immunotherapies in pancreatic ductal adenocarcinoma (PDAC) patients are low. However, cases with long-term survival have been correlated with both T cell infiltration and quality of neoantigens (i.e., epitopes from mutations present
Autor:
Rob C. Oslund, Dewi Harjanto, Jennifer G. Abelin, Jeff Hammerbacher, Yusuf Nasrullah, Sagar Chhangawala, Lia R. Serrano, Alex Rubinsteyn, Gibbs Nasir, Amanda L. Creech, Ying S. Ting, Christopher D. McGann, Asaf Poran, Edward F. Fritsch, Michael S. Rooney, Tyler Colson, Dominik Barthelme, Daniel A. Rothenberg, Scott P. Goulding, Prerna Suri, Terri A. Addona, Matthew Malloy, Christina M. Arieta, Richard B. Gaynor, Diana Velez
Publikováno v:
Cancer Immunology Research. 8:B23-B23
While tumor-reactive CD4+ T cells have been associated with effective immunotherapy responses, accurate prediction of MHC class II-restricted ligands remains a challenge, limiting our ability to harness CD4+ immunity for cancer therapy. To this end,
Autor:
Scott P. Goulding, Christine C. Wu, Nicholas J. Shulman, Michael J. MacCoss, Avinash K. Gadok, Karen K. Szumlinski, Nicholas W. Bateman
Publikováno v:
Molecular & Cellular Proteomics. 13:329-338
Current analytical strategies for collecting proteomic data using data-dependent acquisition (DDA) are limited by the low analytical reproducibility of the method. Proteomic discovery efforts that exploit the benefits of DDA, such as providing peptid
Publikováno v:
Journal of proteomics. 166
In the brain, the Homer protein family modulates excitatory signal transduction and receptor plasticity through interactions with other proteins in dendritic spines. Homer proteins are implicated in a variety of psychiatric disorders such as schizoph
Autor:
Paul F. Worley, Scott P. Goulding, Jia Hua Hu, Matthias Klugmann, Karen K. Szumlinski, Ilona Obara
Publikováno v:
Pain, 2013, Vol.154(10), pp.1932-1945 [Peer Reviewed Journal]
While group 1 metabotropic glutamate receptors (mGluRs) and ionotropic N-methyl-D-aspartate (NMDA) receptors regulate nociception, the precise molecular mechanism(s) contributing to glutamate signaling in chronic pain remain unclear. Here we not only