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of 5
pro vyhledávání: '"Scott O Zeitlin"'
Autor:
Shuqiu Zheng, Erin B D Clabough, Sovan Sarkar, Marie Futter, David C Rubinsztein, Scott O Zeitlin
Publikováno v:
PLoS Genetics, Vol 6, Iss 2, p e1000838 (2010)
Expansion of a stretch of polyglutamine in huntingtin (htt), the protein product of the IT15 gene, causes Huntington's disease (HD). Previous investigations into the role of the polyglutamine stretch (polyQ) in htt function have suggested that its le
Externí odkaz:
https://doaj.org/article/2d361b37d097434f887a4dccdad06df9
Autor:
Deanna M. Marchionini, Jeh-Ping Liu, Alberto Ambesi-Impiombato, Kimberly Kerker, Kim Cirillo, Mukesh Bansal, Rich Mushlin, Daniela Brunner, Sylvie Ramboz, Mei Kwan, Kirsten Kuhlbrodt, Karsten Tillack, Finn Peters, Leena Rauhala, John Obenauer, Jonathan R. Greene, Christopher Hartl, Vinod Khetarpal, Brenda Lager, Jim Rosinski, Jeff Aaronson, Morshed Alam, Ethan Signer, Ignacio Muñoz-Sanjuán, David Howland, Scott O. Zeitlin
Publikováno v:
JCI Insight, Vol 7, Iss 20 (2022)
We have developed an inducible Huntington’s disease (HD) mouse model that allows temporal control of whole-body allele-specific mutant huntingtin (mHtt) expression. We asked whether moderate global lowering of mHtt (~50%) was sufficient for long-te
Externí odkaz:
https://doaj.org/article/134f08ad54bc41838bc7ff1320c3e0ea
Publikováno v:
Neurobiology of Disease, Vol 24, Iss 2, Pp 419-427 (2006)
Huntingtin, the protein product of the Huntington's disease (HD) gene, is known to interact with the tumor suppressor p53. It has recently been shown that activation of p53 upregulates the level of huntingtin, both in vitro and in vivo, whereas p53 d
Externí odkaz:
https://doaj.org/article/629a14ec820d45deb5da9f6aa4560629
Autor:
Todd M. Greco, Christopher Secker, Eduardo Silva Ramos, Joel D. Federspiel, Jeh-Ping Liu, Alma M. Perez, Ismael Al-Ramahi, Jeffrey P. Cantle, Jeffrey B. Carroll, Juan Botas, Scott O. Zeitlin, Erich E. Wanker, Ileana M. Cristea
Publikováno v:
Cell Syst
Huntington’s disease (HD) is a monogenic neurodegenerative disorder with one causative gene, huntingtin (HTT). Yet, HD pathobiology is multifactorial, suggesting that cellular factors influence disease progression. Here, we define HTT protein-prote
Autor:
Scott O. Zeitlin, Jeh-Ping Liu
Huntington disease (HD) is a dominantly inherited neurodegenerative disorder that is caused by a mutant huntingtin (HTT) gene encoding a version of the Htt protein with an expanded polyglutamine stretch. Although the HTT gene was discovered more than
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::885c75a325afde45097d515230823f47
https://europepmc.org/articles/PMC3204854/
https://europepmc.org/articles/PMC3204854/