Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Scott N. Freeman"'
Autor:
Menfo A. Imoisili, Chandana Thorat, M. Ian Phillips, Scott N. Freeman, Kui Xu, Francesca Joseph, Renan Bonnel
Publikováno v:
Pediatrics. 129:516-521
OBJECTIVES: The 1983 US Orphan Drug Act (ODA) provided incentives to stimulate treatment product development for patients with rare disease. This article highlights a decade of ODA contributions to this goal for children with RDs. METHODS: An interna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e32cd17d4c88422972ae2a5f38597bfa
https://doi.org/10.1542/peds.2011-1798
https://doi.org/10.1542/peds.2011-1798
Publikováno v:
Clinical Pharmacology & Therapeutics. 88:449-453
Many neurological diseases or conditions are rare disorders. The Orphan Drug Act (ODA) of 1983 was promulgated to promote the development of products for such conditions. In this Opinion piece, we discuss how the ODA has affected neurological disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a6baf3577ea3c60990ea5aba83cfcde
https://doi.org/10.1038/clpt.2010.193
https://doi.org/10.1038/clpt.2010.193
Publikováno v:
Journal of Biological Chemistry. 283:2353-2362
We have identified the RhoBTB2 putative tumor suppressor gene as a direct target of the E2F1 transcription factor. Overexpression of E2F1 led to up-regulation of RhoBTB2 at the level of mRNA and protein. This also occurred during the induction of E2F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13353fe9b39ffc1a3e46d90e8f8faa6f
https://doi.org/10.1074/jbc.m705986200
https://doi.org/10.1074/jbc.m705986200
Publikováno v:
Cancer Biology & Therapy. 3:1262-1269
E2F1 and E2F4 are known to have opposing roles in cell cycle control. In the present work, we examine the role of both E2F1 and E2F4 in apoptosis induced by three cyclin-dependent kinase inhibitors (roscovitine, BMS-387032, and flavopiridol) as well
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc531c033450bc1ea9b0eb082c1e7ef3
https://doi.org/10.4161/cbt.3.12.1239
https://doi.org/10.4161/cbt.3.12.1239
Autor:
G Bepler, Scott N. Freeman
Publikováno v:
Atlas of Genetics and Cytogenetics in Oncology and Haematology.
Review on RRM1 (ribonucleotide reductase M1), with data on DNA, on the protein encoded, and where the gene is implicated.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc5e654b71e90f09d0e3c0fb5e2b9724
https://doi.org/10.4267/2042/44758
https://doi.org/10.4267/2042/44758
Autor:
W. Douglas Cress, Scott N. Freeman
Publikováno v:
Cancer biologytherapy. 10(11)
Commentary to: Ectopic expression of RhoBTB2 inhibits migration and invasion of human breast cancer cells Li-Jun Ling, Chao Lu, Guo-Ping Zhou and Shui Wang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a31ff3a48a0a68a32d557992688863f
https://pubmed.ncbi.nlm.nih.gov/20930524
https://pubmed.ncbi.nlm.nih.gov/20930524
Publikováno v:
Cell stem cell. 7(3)
The Orphan Drug Act encourages the development of products for rare diseases and conditions. Many conditions that stand to benefit from stem cell-based products are rare diseases. We address the Orphan Drug Act in relation to the development of stem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::076dc5294050e097e11f1016cdd90826
https://pubmed.ncbi.nlm.nih.gov/20804965
https://pubmed.ncbi.nlm.nih.gov/20804965
Publikováno v:
JNCI: Journal of the National Cancer Institute. 97:1088-1089
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03666e10a6fa986c6170998c45e489a4
https://doi.org/10.1093/jnci/dji118
https://doi.org/10.1093/jnci/dji118
Publikováno v:
Cancer Research. 71:5537-5537
RRM1 (ribonucleotide reductase M1) is a key enzyme involved in deoxyribonucleotide (dNTP) synthesis and DNA damage repair. It also plays a critical role in acquired resistance to the chemotherapy drug gemcitabine, which directly inhibits the RR holoe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6a61a933f1274535e7924df8c375ab9
https://doi.org/10.1158/1538-7445.am2011-5537
https://doi.org/10.1158/1538-7445.am2011-5537
Publikováno v:
Cancer Research. 71:88-88
The Wnt signaling pathway is critical to normal development but the involvement of the pathway in lung tumorigenesis has not been clearly established. Wnt7a, with its receptor Fzd9, is required for maintenance of epithelial differentiation and inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6e0e1dab406c7ddeb2498e5e2dd447c
https://doi.org/10.1158/1538-7445.am2011-88
https://doi.org/10.1158/1538-7445.am2011-88