Zobrazeno 1 - 10
of 263
pro vyhledávání: '"Scott McIvor"'
Autor:
Miles C. Smith, Lalitha R. Belur, Andrea D. Karlen, Olivia Erlanson, Justin Furcich, Troy C. Lund, Davis Seelig, Kelley F. Kitto, Carolyn A. Fairbanks, Kwi Hye Kim, Nick Buss, R. Scott McIvor
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 1, Pp 101201- (2024)
Mucopolysaccharidosis type II (MPS II) is an X-linked recessive lysosomal disease caused by iduronate-2-sulfatase (IDS) deficiency, leading to accumulation of glycosaminoglycans (GAGs) and the emergence of progressive disease. Enzyme replacement ther
Externí odkaz:
https://doaj.org/article/a2a8c79881364444bb7633c2c34e66ec
Autor:
Caroline C. Churchill, Cristina D. Peterson, Kelley F. Kitto, Kelsey R. Pflepsen, Lalitha R. Belur, R. Scott McIvor, Lucy Vulchanova, George L. Wilcox, Carolyn A. Fairbanks
Publikováno v:
Frontiers in Pain Research, Vol 4 (2024)
Agmatine, a decarboxylated form of L-arginine, prevents opioid analgesic tolerance, dependence, and self-administration when given by both central and systemic routes of administration. Endogenous agmatine has been previously detected in the central
Externí odkaz:
https://doaj.org/article/52efa26146094fbbb8d8e7459e96d505
Autor:
Reshma Gore, Tina Esmail, Kelsey Pflepsen, Ezequiel Marron Fernandez de Velasco, Kelley F. Kitto, Maureen S. Riedl, Andrea Karlen, R. Scott McIvor, Christopher N. Honda, Carolyn A. Fairbanks, Lucy Vulchanova
Publikováno v:
Frontiers in Pain Research, Vol 4 (2023)
Investigation of neural circuits underlying visceral pain is hampered by the difficulty in achieving selective manipulations of individual circuit components. In this study, we adapted a dual AAV approach, used for projection-specific transgene expre
Externí odkaz:
https://doaj.org/article/267d366a68584b458e50530348ee8317
Autor:
Kanut Laoharawee, Kelly M. Podetz-Pedersen, Tam T. Nguyen, Sajya M. Singh, Miles C. Smith, Lalitha R. Belur, Walter C. Low, Karen F. Kozarsky, R. Scott McIvor
Publikováno v:
Molecular Genetics and Metabolism Reports, Vol 34, Iss , Pp 100956- (2023)
Hunter syndrome is a rare x-linked recessive genetic disorder that affects lysosomal metabolism due to deficiency of iduronate-2-sulfatase (IDS), with subsequent accumulation of glycosaminoglycans heparan and dermatan sulfates (GAG). Enzyme replaceme
Externí odkaz:
https://doaj.org/article/844641009ad346d0b12f5b18be323ac8
Autor:
Cristina D. Peterson, Jonathan J. Waataja, Kelley F. Kitto, Samuel J. Erb, Harsha Verma, Daniel J. Schuster, Caroline C. Churchill, Maureen S. Riedl, Lalitha R. Belur, Daniel A. Wolf, R. Scott McIvor, Lucy Vulchanova, George L. Wilcox, Carolyn A. Fairbanks
Publikováno v:
Molecular Therapy. 31:1123-1135
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89ff3cb56261bbdd921fd54b608173c1
https://doi.org/10.1016/j.ymthe.2023.01.022
https://doi.org/10.1016/j.ymthe.2023.01.022
Autor:
Lalitha R. Belur, Megan Romero, Junggu Lee, Kelly M. Podetz-Pedersen, Zhenhong Nan, Maureen S. Riedl, Lucy Vulchanova, Kelley F. Kitto, Carolyn A. Fairbanks, Karen F. Kozarsky, Paul J. Orchard, William H. Frey, Walter C. Low, R. Scott McIvor
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Mucopolysaccharidosis type I (MPS I) is an inherited metabolic disorder caused by deficiency of the lysosomal enzyme alpha-L-iduronidase (IDUA). The two current treatments [hematopoietic stem cell transplantation (HSCT) and enzyme replacement therapy
Externí odkaz:
https://doaj.org/article/612b20e3a1914626b04655208aae2b85
Autor:
Kelly M. Podetz-Pedersen, Kanut Laoharawee, Sajya Singh, Tam T. Nguyen, Miles C. Smith, Alexa Temme, Karen Kozarsky, R. Scott McIvor, Lalitha R. Belur
Publikováno v:
Human Gene Therapy. 34:8-18
The mucopolysaccharidoses (MPS) are a group of recessively inherited conditions caused by deficiency of lysosomal enzymes essential to the catabolism of glycosaminoglycans. MPS I is caused by deficiency of the lysosomal enzyme alpha-L-iduronidase (ID
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d79d1578844c99aeb3d28ce7862ff36c
https://doi.org/10.1089/hum.2022.162
https://doi.org/10.1089/hum.2022.162
Autor:
Miles C. Smith, Lalitha R. Belur, Andrea D. Karlen, Olivia Erlanson, Kelly M. Podetz-Pedersen, Jessica McKenzie, Jenn Detellis, Khatuna Gagnidze, Geoffrey Parsons, Nicholas Robinson, Shelby Labarre, Saumil Shah, Justin Furcich, Troy C. Lund, Hsing-Chen Tsai, R. Scott McIvor, Melissa Bonner
Publikováno v:
Human Gene Therapy. 33:1279-1292
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdfc4a893a7f592726a497c6e2ab15bd
https://doi.org/10.1089/hum.2022.141
https://doi.org/10.1089/hum.2022.141
Autor:
Matthew Johnson, Ying Hu, Nicholas Restifo, Jared Gartner, Douglas Palmer, Shashank Patel, Maria Parkhurst, Todd Prickett, Parisa Malekzadeh, David McKenna, Zulmarie Franco, Suman Vodnala, Beau Webber, Yogin Patel, Christine Kariya, Walker Lahr, Rigel Kishton, Devikala Gurusamy, Miechaleen Diers, Natalie Wolf, Nicholas Slipek, Darin Sumstad, Lydia Viney, Tom Henley, Tilmann Bürckstümmer, Oliver Baker, Chunhua Yan, Daoud Meerzaman, Kartik Padhan, Winnie Lo, Li Jia, Drew Deniger, R Scott McIvor, Modassir Choudhry, Branden Moriarity
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/410d0e5f91994125860cead103ddfd28
Autor:
Lalitha R. Belur, Kelly M. Podetz-Pedersen, Thuy An Tran, Joshua A. Mesick, Nathaniel M. Singh, Maureen Riedl, Lucy Vulchanova, Karen F. Kozarsky, R. Scott McIvor
Publikováno v:
Molecular Genetics and Metabolism Reports, Vol 24, Iss , Pp 100604- (2020)
Mucopolysaccharidosis type I (MPS I) is an inherited metabolic disorder caused by deficiency of alpha-L-iduronidase (IDUA), resulting in accumulation of heparan and dermatan sulfate glycosaminoglycans (GAGs). Individuals with the most severe form of
Externí odkaz:
https://doaj.org/article/5bed40c4b92e49d5a837dddbf675bf7e