Výsledky vyhledávání - "Scott McElhone"

Impact of copy neutral loss of heterozygosity and total genome aberrations on survival in myelodysplastic syndrome

Autor: Cecilia C. S. Yeung, David P Ng, Scott McElhone, Xue Yan Chen, Min Fang, Barry E. Storer, H. Joachim Deeg

Publikováno v: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

Myelodysplastic syndromes (MDS) are a heterogeneous group of diseases with varying genetic aberrations. Half of MDS patients have normal karyotype, obscuring the underlying condition indicating a need for new markers for improved diagnostics and prog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba0e091c22723de0eaf0784b2469420f
https://doi.org/10.1038/modpathol.2017.157

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Prognostic significance of acquired copy-neutral loss of heterozygosity in acute myeloid leukemia

Autor: Elihu H. Estey, Frederick R. Appelbaum, Vicky Sandhu, Matthew L. Fero, Min Fang, Kathleen Kroeger, Barry E. Storer, Christine M. Gronseth, Scott McElhone

Publikováno v: Cancer. 121:2900-2908

BACKGROUND Chromosomal abnormalities are important in the diagnosis and prognosis of patients with acute myeloid leukemia (AML). Genomic microarray techniques detect recurrent copy-neutral loss of heterozygosity (cnLOH) in addition to copy number abe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dfdd9bf8e12edd921d4bc4e1b9afc29a
https://doi.org/10.1002/cncr.29475

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Monotypic Human Immunodeficiency Virus Type 1 Genotypes across the Uterine Cervix and in Blood Suggest Proliferation of Cells with Provirus

Autor: Jane Hitti, Robert W. Coombs, Scott McElhone, Gerald H. Learn, Sarah Holte, James I. Mullins, David Lockhart, Joan Dragavon, Marta E. Bull, Lisa M. Frenkel

Publikováno v: Journal of Virology. 83:6020-6028

Understanding the dynamics and spread of human immunodeficiency virus type 1 (HIV-1) within the body, including within the female genital tract with its central role in heterosexual and peripartum transmission, has important implications for treatmen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af1d68f68bb7ba46f6ad0335b6a7e233
https://doi.org/10.1128/jvi.02664-08

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OR6 Next generation sequencing HLA typing in patients with copy neutral loss of heterozygosity

Autor: Fredrick Oakley, Gansuvd Balgansuren, Scott McElhone, Min Fang, Randy Williams, Rita C. Witherspoon, Lois E. Regen, Paula Peterson

Publikováno v: Human Immunology. 78:7

Aim Next Generation Sequencing (NGS) technology is well documented as a highly sensitive and specific method for HLA typing. Here we investigate the possibility that copy neutral loss of Heterozygosity (cnLOH) involving the HLA complex located at 6p2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9093782668040424c11c27e493006cdb
https://doi.org/10.1016/j.humimm.2017.06.012

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Proof-Of-Concept Study For Precision Medicine With Chromosome Genomic Array Testing (CGAT) For Drug Sensitivity Screening In Acute Myeloid Leukemia

Autor: Frederick R. Appelbaum, Pamela S. Becker, Su-In Lee, Min Fang, Scott McElhone, Vivian G. Oehler, Barry E. Storer, C. Anthony Blau, Elihu H. Estey, Xin Zhao

Publikováno v: Blood. 122:2578-2578

Tremendous heterogeneity in acute myeloid leukemia (AML) poses a significant challenge to clinical management and effective therapy. Cytogenetics is one of the key prognostic factors for AML. New technologies, such as chromosome genomic array testing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4a3d7b6f00b67605e192a6740f9320d4
https://doi.org/10.1182/blood.v122.21.2578.2578

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4-OR

Autor: Shalini Pereira, Sandra Warnock, Min Fang, Scott McElhone, Maggie Sprague, Lois E. Regen

Publikováno v: Human Immunology. 74:4

Aim Saliva is fast becoming an alternative to buccal cells as a source of DNA for HLA typing prior to hematopoietic cell transplant (HCT), either when a peripheral blood sample is not an option or as a source of germline DNA. We describe the case of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d31451165412572f2d5c7c70ba75d333
https://doi.org/10.1016/j.humimm.2013.08.015

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Unique Challenges and Discoveries From Chromosome Genomic Array Testing (CGAT) in the Setting of Hematopoietic Cell Transplantation

Autor: Scott McElhone, Shalini E. Pereira, Melissa Chiu, Min Fang, Cynthia Friedman

Publikováno v: Cancer Genetics. 206:212

The clinical utility of chromosome genomic array testing (CGAT) is increasingly appreciated for cancer diagnosis. The detection of copy number aberrations (CNAs) and copy-neutral LOH (cnLOH) significantly enhance diagnostic yield and provide for addi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::26feb3cfbfbcb841f2f44ef968a68a70
https://doi.org/10.1016/j.cancergen.2013.05.005

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