Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Scott Maynard"'
Autor:
Martin Kosar, Michele Giannattasio, Daniele Piccini, Apolinar Maya-Mendoza, Francisco García-Benítez, Jirina Bartkova, Sonia I. Barroso, Hélène Gaillard, Emanuele Martini, Umberto Restuccia, Miguel Angel Ramirez-Otero, Massimiliano Garre, Eleonora Verga, Miguel Andújar-Sánchez, Scott Maynard, Zdenek Hodny, Vincenzo Costanzo, Amit Kumar, Angela Bachi, Andrés Aguilera, Jiri Bartek, Marco Foiani
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Tpr nucleoporin is known to be essential for nuclear transport and mitosis processes. Here the authors explore the link between Tpr and genome instability providing insights into the role of Tpr in safeguarding cells from RNA-mediated replication str
Externí odkaz:
https://doaj.org/article/18fbf66c3f8442a6835b1d14c7f9ffa2
Autor:
Rie Harboe Nygaard, Scott Maynard, Peter Schjerling, Michael Kjaer, Klaus Qvortrup, Vilhelm A. Bohr, Lene J. Rasmussen, Gregor B.E. Jemec, Michael Heidenheim
Publikováno v:
Case Reports in Dermatology, Vol 8, Iss 1, Pp 42-51 (2016)
Cutis laxa is a rare disease characterized by abnormal skin wrinkling and laxity, due to decreased elastin synthesis or structural extracellular matrix defects. We have explored elastin metabolism in a case of adult onset cutis laxa localized to the
Externí odkaz:
https://doaj.org/article/8550b8c8fbf64ec69c60ee65222f6519
Autor:
Scott Maynard, Arnaldur Hall, Panagiotis Galanos, Salvatore Rizza, Tatsuro Yamamoto, Helena Hagner Gram, Sebastian H N Munk, Muhammad Shoaib, Claus Storgaard Sørensen, Vilhelm A Bohr, Mads Lerdrup, Apolinar Maya-Mendoza, Jiri Bartek
Publikováno v:
Maynard, S, Hall, A, Galanos, P, Rizza, S, Yamamoto, T, Gram, H H, Munk, S H N, Shoaib, M, Sørensen, C S, Bohr, V A, Lerdrup, M, Maya-Mendoza, A & Bartek, J 2022, ' Lamin A/C impairments cause mitochondrial dysfunction by attenuating PGC1 and the NAMPT-NAD + pathway ', Nucleic Acids Research, vol. 50, no. 17, pp. 9948-9965 . https://doi.org/10.1093/nar/gkac741
Mutations in the lamin A/C gene (LMNA) cause laminopathies such as the premature aging Hutchinson Gilford progeria syndrome (HGPS) and altered lamin A/C levels are found in diverse malignancies. The underlying lamin-associated mechanisms remain poorl
Autor:
Jiri Bartek, Arnaldur Hall, Lin-Ping Wu, Robert Strauss, Joanna Maria Merchut-Maya, Seyed Moein Moghimi, Scott Maynard
Publikováno v:
Journal of Controlled Release. 309:158-172
Acquired resistance to the oncogenic BRAFE600 inhibitor vemurafenib is a major clinical challenge in the treatment of melanoma. Vemurafenib resistance is poorly understood; however, available evidence indicates that reprogrammed mitochondrial metabol
Autor:
Arnaldur Hall, Morten Scheibye-Knudsen, Scott Maynard, Mansour Akbari, Marya Morevati, Guido Keijzers, Susana Gonzalo, Michael Ben Ezra, Vilhelm A. Bohr, Jiri Bartek
Publikováno v:
Nucleic acids research. 47(22)
The A-type lamins (lamin A/C), encoded by the LMNA gene, are important structural components of the nuclear lamina. LMNA mutations lead to degenerative disorders known as laminopathies, including the premature aging disease Hutchinson-Gilford progeri
Autor:
Arnaldur, Hall, Scott, Maynard, Lin-Ping, Wu, Joanna Maria, Merchut-Maya, Robert, Strauss, Seyed Moein, Moghimi, Jiri, Bartek
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 309
Acquired resistance to the oncogenic BRAF
Autor:
Gregor B.E. Jemec, Michael Heidenheim, Rie Harboe Nygaard, Peter Schjerling, Lene Juel Rasmussen, Michael Kjaer, Klaus Qvortrup, Scott Maynard, Vilhelm A. Bohr
Publikováno v:
Nygaard, R H, Maynard, S, Schjerling, P, Kjaer, M, Qvortrup, K, Bohr, V A, Rasmussen, L J, Jemec, G & Heidenheim, M 2016, ' Acquired Localized Cutis Laxa Due to Increased Elastin Turnover ', Journal of dermatological case reports .
Nygaard, R H, Maynard, S, Schjerling, P, Kjær, M, Qvortrup, K, Bohr, V A, Rasmussen, L J, Jemec, G B E & Heidenheim, M 2016, ' Acquired Localized Cutis Laxa due to Increased Elastin Turnover ', Case Reports in Dermatology, vol. 8, no. 1, pp. 42-51 . https://doi.org/10.1159/000443696
Case Reports in Dermatology, Vol 8, Iss 1, Pp 42-51 (2016)
Case Reports in Dermatology
Nygaard, R H, Maynard, S, Schjerling, P, Kjær, M, Qvortrup, K, Bohr, V A, Rasmussen, L J, Jemec, G B E & Heidenheim, M 2016, ' Acquired Localized Cutis Laxa due to Increased Elastin Turnover ', Case Reports in Dermatology, vol. 8, no. 1, pp. 42-51 . https://doi.org/10.1159/000443696
Case Reports in Dermatology, Vol 8, Iss 1, Pp 42-51 (2016)
Case Reports in Dermatology
Cutis laxa is a rare disease characterized by abnormal skin wrinkling and laxity, due to decreased elastin synthesis or structural extracellular matrix defects. We have explored elastin metabolism in a case of adult onset cutis laxa localized to the
Autor:
Karen Rethoret, P-A Bédard, Tetsuaki Miyake, Mark Gagliardi, Romita Ghosh, Ying Wu, Shi Yan, Scott Maynard
Publikováno v:
Journal of Cellular Physiology. 230:1475-1488
Nutrient depletion triggers a series of adaptive processes as part of the unfolded protein response or UPR. These processes reduce stress to the endoplasmic reticulum by enhancing its protein folding capacity or ability to promote the degradation of
Publikováno v:
Methods. 51:416-425
The main source of mitochondrial DNA (mtDNA) damage is reactive oxygen species (ROS) generated during normal cellular metabolism. The main mtDNA lesions generated by ROS are base modifications, such as the ubiquitous 8-oxoguanine (8-oxoG) lesion; how
Autor:
Scott Maynard, Kazunari Hashiguchi, Jingping Hu, Nadja C. de Souza-Pinto, Vilhelm A. Bohr, Meltem Muftuoglu
Publikováno v:
Molecular and Cellular Biology. 29:4441-4454
Oxidized bases are common types of DNA modifications. Their accumulation in the genome is linked to aging and degenerative diseases. These modifications are commonly repaired by the base excision repair (BER) pathway. Oxoguanine DNA glycosylase (OGG1