Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Scott Martin Sheehan"'
Autor:
Scott Martin Sheehan, Nikolay Y. Chirgadze, Gerald F. Smith, Jolie Anne Bastian, Michael Robert Wiley, Trelia J. Craft, Daniel Jon Sall, Jeffrey K. Smallwood, Jothirajah Marimuthu, John Walter Nr Macclesfield Liebeschuetz, Marcia K. Chastain, Philip Sipes, Jeffry Bernard Franciskovich, Brian Morgan Watson, Ronald S. Foster, Valentine J. Klimkowski
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:5801-5805
Analogs to a series of D-phenylglycinamide-derived factor Xa inhibitors were discovered. It was found that the S4 amide linkage can be replaced with an ether linkage to reduce the peptide character of the molecules and that this substitution leads to
Autor:
Brian Michael Mathes, Zhixiang Yang, Dustin J. Mergott, Scott A. Monk, Hykop Gevorkyan, Larry Ereshefsky, Vaught Grant Matthews, Leonard L. Winneroski, Jon A. Erickson, Stephen L. Lowe, Celedon Gonzales, Scott Martin Sheehan, David E. Timm, Brian Morgan Watson, Ferenc Martenyi, David O. Calligaro, Stephanie L. Stout, Theresa A. Day, Richard A. Brier, Patrick J Cocke, Brian A. Willis, Stanford Jhee, Leonard N. Boggs, Robert A. Dean, James E. Audia, Steven F. Komjathy, Anthony R. Borders, Terry D. Lindstrom, Patrick C. May, Douglas E. James, Linglin Li
BACE1 is a key protease controlling the formation of amyloid β, a peptide hypothesized to play a significant role in the pathogenesis of Alzheimer's disease (AD). Therefore, the development of potent and selective inhibitors of BACE1 has been a focu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f78c69adc5fae76e66024d7197aeccfc
https://europepmc.org/articles/PMC6605527/
https://europepmc.org/articles/PMC6605527/
Autor:
Jothirajah Marimuthu, Mark W. Farmen, Wayne W. Weber, Stuart Donald Jones, Kyle Ja, Michael Robert Wiley, John Walter Liebeschuetz, David Birenbaum Engel, Jeffrey K. Smallwood, Jeffrey B. Franciskovich, Christopher W. Murray, John Joseph Masters, Gerald F. Smith, Scott Martin Sheehan, Stephen Clinton Young
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:2255-2259
A novel isonitrile derivative was synthesized and used in an Ugi four component coupling reaction to explore aryl group substitution effects on inhibition of the coagulation cascade serine protease factor Xa.
Autor:
Manuel Vicente Sanchez-Felix, Patrick C. May, David O. Calligaro, James E. Audia, Suizhen Lin, Leonard N. Boggs, Zhixiang Yang, Dustin J. Mergott, Scott A. Monk, Theresa A. Day, Richard A. Brier, Vaught Grant Matthews, Terry D. Lindstrom, Martin Citron, Scott Martin Sheehan
Publikováno v:
Alzheimer's & Dementia. 8
Autor:
Martin Citron, Zhixiang Yang, James E. Audia, David O. Calligaro, Patrick C. May, Scott Martin Sheehan, Terry D. Lindstrom, Leonard N. Boggs
Publikováno v:
Alzheimer's & Dementia. 6
Autor:
Brian Morgan Watson, Patrick C. May, Terry D. Lindstrom, Leonard N. Boggs, Scott Martin Sheehan, James E. Audia
Publikováno v:
Alzheimer's & Dementia. 6
Autor:
Andre Boelke, Emily Jane Canada, Brian Morgan Watson, Valentine J. Klimkowski, Michael Mohr, Qing Shi, David E. Timm, Shon Roland Pulley, Andreas Gerhard Weichert, Hans-Juergen Mest, J. Michael Kalbfleisch, Elizabeth A. Dingess-Hammond, Johann-Christian Zechel, Gerd Ruehter, Brandon J. Margolis, Soenke Petersen, Michael Robert Wiley, Graham N. Wishart, Annick J. Cauvin, Beatrice Renson, Stephen Parsons, Larry C. Blaszczak, Dirk Hankotius, Britta Evers, Scott Martin Sheehan
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(6)
A series of non-covalent inhibitors of the serine protease dipeptidyl peptidase IV (DPP-IV) were found to adopt a U-shaped binding conformation in X-ray co-crystallization studies. Remarkably, Tyr547 undergoes a 70 degrees side-chain rotation to acco
Autor:
Scott Martin Sheehan
Publikováno v:
ChemInform. 34