Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Scott M. Thacher"'
Publikováno v:
Cancer Research. 82:LB144-LB144
Leydig cell tumors (LCT), originating from androgen-producing interstitial Leydig cells of the testis, represent about 3% of all testicular cancers. LCT belong to the family of sex cord stromal tumors (SCST), a collection of tumors formed in the supp
Publikováno v:
Journal of the Endocrine Society
Adrenocortical carcinoma (ACC) is an aggressive cancer with devastating outcomes. ACC is usually locally advanced or metastatic at diagnosis and, despite tumor resection plus chemotherapy, has a high rate of recurrence. The 5-year survival rate among
Autor:
Neil Raheja, Haiyan Tao, Ray Fox, Emily Eastwood, Scott M. Thacher, Paul D. Crowe, Raul C. Ribeiro
Publikováno v:
Journal of the Endocrine Society. 5:A1010-A1010
Adrenocortical carcinoma (ACC) is a rare cancer with an annual incidence of 0.7-2.0 cases per million in the US and EU. Surgical resection combined with adjuvant chemotherapy remains the primary treatment for patients with advanced disease. Although
Autor:
Akihiro Nomura, Kojo Arita, Paul D. Crowe, Kazuyuki Hirata, Makoto Shiozaki, Keisuke Ito, Naoki Miyagawa, Yoshiaki Katsuda, Kota Asahina, Hiromasa Hashimoto, Yoshihiro Suwa, Masayuki Kotoku, Haiyan Tao, Yasunori Hase, Yokota Masahiro, Seki Noriyoshi, Fujioka Shingo, Satoki Doi, Tsuyoshi Adachi, Masato Noguchi, Scott M. Thacher, Takayoshi Suzuki, Taku Ikenogami, Takaki Maeba
Publikováno v:
Journal of medicinal chemistry. 62(5)
Starting from a previously reported RORγ inhibitor (1), successive efforts to improve in vivo potency were continued. Introduction of metabolically beneficial motifs in conjunction with scaffold hopping was examined, resulting in discovery of the se
Autor:
Andrew M. Standeven, Maria Escobar, Roshantha A.S. Chandraratna, Yang-Dar Yuan, Vidyasagar Vuligonda, Richard L. Beard, Scott M. Thacher
Publikováno v:
Biochemical Pharmacology. 62:1501-1509
Hypertriglyceridemia is a major side-effect of retinoid therapy in humans. We previously reported that agonists for the retinoic acid receptors (RARs), but not the retinoid X receptors (RXRs), elevate serum triglycerides in male Fischer rats, and tha
Publikováno v:
Journal of Medicinal Chemistry. 44:2298-2303
The synthesis and characterization of chiral RXR selective ligands are described. The enantiomeric acids 2 and 3 were synthesized employing an enantioselective cylopropanation procedure as the key step. Compound 2, with an S,S configuration at C-9 an
Autor:
Jayasree Vasudevan, Roshantha A.S. Chandraratna, Scott M. Thacher, Kwok-Yin Tsang, Sunil Nagpal
Publikováno v:
Journal of Medicinal Chemistry. 44:281-297
Publikováno v:
Current Pharmaceutical Design. 6:25-58
Synthetic retinoids, ligands for the RAR and RXR members of the steroid/thyroid superfamily of nuclear hormone receptors, are used for the treatment of psoriasis, acne, photoaging and cancer. Retinoid mechanisms of action for these conditions largely
Autor:
Ajit K. Verma, Guo Quan Chen, Lawrence Toll, Braham Shroot, Longchuan Bai, Jian Gu, Wan Ru Chao, Marcia I. Dawson, Donald L. Hill, Xiao-kun Zhang, Ju Hui Park, Ling Jong, Juanita L. Merchant, Linda Dousman, Scott M. Thacher, Peter D. Hobbs, Anissa Agadir, Nahid Waleh, Roshantha A.S. Chandraratna
Publikováno v:
International Journal of Cancer. 91:8-21
Evaluation of retinoic acid receptor (RAR) subtype-selective alpha and gamma agonists and antagonists and a retinoid X receptor (RXR) class-selective agonist for efficacy at inhibiting both induction of ornithine decarboxylase (ODC) by the tumor prom
Autor:
Roshantha A.S. Chandraratna, Richard L. Beard, Diana F. Colon, Scott M. Thacher, Taghreed Arefieg, Tien T. Duong, Min Teng
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2373-2378
Retinoids are natural and synthetic analogs of the hormone retinoic acid. Retinoids are currently being investigated clinically as drugs in several areas, including dermatology and oncology. We report the synthesis and biological activity of a new se