Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Scott M. Ocheltree"'
Publikováno v:
Brain Research. 1221:6-13
Previous studies by our group have shown that peripheral inflammatory insult, using the lambda-carrageenan inflammatory pain (CIP) model, induced alterations in the molecular and functional properties of the blood-brain barrier (BBB). The question re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faf8bf7cc0b7e2e3a3253b3ccd8d86ef
https://doi.org/10.1016/j.brainres.2008.05.013
https://doi.org/10.1016/j.brainres.2008.05.013
Publikováno v:
Drug Metabolism and Disposition. 35:1209-1216
The aim of this study was to examine the role of PEPT2, a proton-coupled oligopeptide transporter of the SLC15 family, on the disposition of the antibiotic cefadroxil in the body, particularly the kidney and brain. Pharmacokinetic, tissue distributio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b3f11b37150efedc10e36bf82b71b0b
https://doi.org/10.1124/dmd.107.015263
https://doi.org/10.1124/dmd.107.015263
Autor:
Rachael A. Charles, Tracy A. Brooks, Richard D. Egleton, Scott M. Ocheltree, Melissa J. Seelbach, Nicole Nametz, Thomas P. Davis
Publikováno v:
Brain Research. 1120:172-182
The blood–brain barrier (BBB) is a dynamic system which maintains brain homeostasis and limits CNS penetration via interactions of transmembrane and intracellular proteins. Inflammatory pain (IP) is a condition underlying several diseases with know
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdc07fff4bd8e92e7c5ea64cdc5afb70
https://doi.org/10.1016/j.brainres.2006.08.085
https://doi.org/10.1016/j.brainres.2006.08.085
Publikováno v:
Pharmaceutical Research. 22:1281-1286
The purpose of this research was to determine the polarity and directionality of the PEPT2-mediated uptake and transepithelial transport of the neuropeptide glycyl-L-glutamine (GlyGln) in choroid plexus.The transport kinetics of [3H]GlyGln was studie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b246bf90ed196ef16924df2a9894321
https://doi.org/10.1007/s11095-005-5261-0
https://doi.org/10.1007/s11095-005-5261-0
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 308:462-467
The choroid plexus uptake of [(3)H]cefadroxil was studied in peptide transporter 2 (PEPT2) wild-type and null mice as a function of temperature, transport inhibitors, pH, and saturability. At normal pH (7.4) and temperature (37 degrees C), the uptake
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::505fb0ba12d4fd61c8e9e2d54be0982f
https://doi.org/10.1124/jpet.103.060400
https://doi.org/10.1124/jpet.103.060400
Publikováno v:
Pharmaceutical Research. 20:1364-1372
Purpose. To determine the expression and functional activity of proton-coupled oligopeptide transporters (POT) in retinal pigment epithelial (RPE) cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::040c139921edd8d10191b5a56659b47e
https://doi.org/10.1023/a:1025741723724
https://doi.org/10.1023/a:1025741723724
Publikováno v:
The FASEB Journal. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b716b6e62f115867c6e273489097d835
https://doi.org/10.1096/fasebj.22.1_supplement.184.5
https://doi.org/10.1096/fasebj.22.1_supplement.184.5
Investigations of the blood-brain barrier (BBB) in diabetes have yielded contradictory results. It is possible that diabetes differentially affects paracellular and transcellular permeabilities via modulation of tight junction and transport proteins,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1fd9d30df553d23149e012d8aecfa24
https://europepmc.org/articles/PMC1785293/
https://europepmc.org/articles/PMC1785293/
Publikováno v:
The FASEB Journal. 20
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::760f6e99e8c48d6c71309173e9ec2b87
https://doi.org/10.1096/fasebj.20.4.a377-b
https://doi.org/10.1096/fasebj.20.4.a377-b
Publikováno v:
The FASEB Journal. 20
The strategic localization of efflux transporters (e.g., P-gp, MRP1, BCRP) to the apical and basolateral membranes of the choroid plexus suggests that they play important roles in the disposition o...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0bac39ebed0d1f24eb325ffebe82af2
https://doi.org/10.1096/fasebj.20.5.a1143
https://doi.org/10.1096/fasebj.20.5.a1143