Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Scott M. Leighow"'
Autor:
Thu Nguyen-Anh Tran, Nathan B. Wikle, Emmy Albert, Haider Inam, Emily Strong, Karel Brinda, Scott M. Leighow, Fuhan Yang, Sajid Hossain, Justin R. Pritchard, Philip Chan, William P. Hanage, Ephraim M. Hanks, Maciej F. Boni
Publikováno v:
BMC Medicine, Vol 19, Iss 1, Pp 1-14 (2021)
Abstract Background When three SARS-CoV-2 vaccines came to market in Europe and North America in the winter of 2020–2021, distribution networks were in a race against a major epidemiological wave of SARS-CoV-2 that began in autumn 2020. Rapid and o
Externí odkaz:
https://doaj.org/article/cb937e87c69747779b6d269f47db0b01
Publikováno v:
Cell Reports, Vol 30, Iss 12, Pp 3951-3963.e4 (2020)
Summary: Rationally designing drugs that last longer in the face of biological evolution is a critical objective of drug discovery. However, this goal is thwarted by the diversity and stochasticity of evolutionary trajectories that drive uncertainty
Externí odkaz:
https://doaj.org/article/4b1b504584ba4c028c270886dafe7cbd
Autor:
Maciej F. Boni, Emmy Albert, Fuhan Yang, Scott M. Leighow, Thu Nguyen Anh Tran, Philip A. Chan, William P. Hanage, Ephraim M. Hanks, Nathan B. Wikle, Karel Brinda, Emily R Strong, Justin R. Pritchard, Haider Inam, Sajid Hossain
Publikováno v:
BMC Medicine, Vol 19, Iss 1, Pp 1-14 (2021)
Background When three SARS-CoV-2 vaccines came to market in Europe and North America in the winter of 2020–2021, distribution networks were in a race against a major epidemiological wave of SARS-CoV-2 that began in autumn 2020. Rapid and optimized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c6c54f8a4ae2428ff425ec5488ce31e
https://doaj.org/article/cb937e87c69747779b6d269f47db0b01
https://doaj.org/article/cb937e87c69747779b6d269f47db0b01
Structured AbstractIntroductionModern targeted cancer therapies are carefully crafted small molecules. These exquisite technologies exhibit an astonishing diversity of failure modes (drug resistance mechanisms) in the clinic. This diversity is surpri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11e5f3cf3c3dd3fcaf9ad9114a9c98e4
https://doi.org/10.1101/2022.02.25.481999
https://doi.org/10.1101/2022.02.25.481999
Autor:
Maciej F. Boni, Philip A. Chan, Fuhan Yang, William P. Hanage, Thu Nguyen Anh Tran, Justin R. Pritchard, Haider Inam, Nathan B. Wikle, Joseph Albert, Sajid Hossain, Ephraim M. Hanks, Emily R Strong, Scott M. Leighow, Karel Brinda
Publikováno v:
BMC Medicine
Background When three SARS-CoV-2 vaccines came to market in Europe and North America in the winter of 2020–2021, distribution networks were in a race against a major epidemiological wave of SARS-CoV-2 that began in autumn 2020. Rapid and optimized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb9026e83a70e2b0fd3b63ef23998767
https://doi.org/10.1101/2021.01.12.21249694
https://doi.org/10.1101/2021.01.12.21249694
Publikováno v:
Cancer Research. 82:B007-B007
This abstract is being presented as a short talk in the scientific program. A full abstract is available in the Proffered Abstracts section (PR014) of the Conference Proceedings. Citation Format: Scott M. Leighow, Haider Inam, Justin R. Pritchard. De
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b14134a87a8e892fcb839a03aa366f6
https://doi.org/10.1158/1538-7445.evodyn22-b007
https://doi.org/10.1158/1538-7445.evodyn22-b007
SummaryTheoretical treatments of evolutionary dynamics tend to model the probability that a single “resistant” species will arise in a population. However, experimental studies have identified a diversity of mutations that can lead to genetic res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3485d8adf87deefe193c2cc48b59565b
Publikováno v:
Cell reports
Cell Reports, Vol 30, Iss 12, Pp 3951-3963.e4 (2020)
Cell Reports, Vol 30, Iss 12, Pp 3951-3963.e4 (2020)
SUMMARY Rationally designing drugs that last longer in the face of biological evolution is a critical objective of drug discovery. However, this goal is thwarted by the diversity and stochasticity of evolutionary trajectories that drive uncertainty i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d39154ddbf23ff2705f05d74af599440
http://europepmc.org/articles/PMC8000225
http://europepmc.org/articles/PMC8000225
Autor:
Bella I. Aminov, Victor M. Rivera, Justin R. Pritchard, Lawrence A. Loeb, Jerald P. Radich, Lan Beppu, Daniel S. Kim, Scott M. Leighow, Michael W. Schmitt, J. Graeme Hodgson
Purpose: Sequential treatment with targeted therapies can result in complex combinations of resistance mutations in drug targets. This mutational complexity has spurred the development of pan-target inhibitors, i.e., therapies for which no single tar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bd22e29e92a49811a7fd655a7f19e6a
https://europepmc.org/articles/PMC6214777/
https://europepmc.org/articles/PMC6214777/
Autor:
Scott M. Leighow, Justin R. Pritchard
Publikováno v:
Evolution, Medicine, and Public Health
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a781715c92ccc9ef8dddf52a9b6d49eb
https://doi.org/10.1093/emph/eoz013
https://doi.org/10.1093/emph/eoz013