Spatiotemporal expression and control of haemoglobin in space

Autor: Josef Borg, Conor Loy, JangKeun Kim, Alfred Buhagiar, Christopher Chin, Namita Damle, Iwijn De Vlaminck, Alex Felice, Tammy Liu, Irina Matei, Cem Meydan, Masafumi Muratani, Omary Mzava, Eliah Overbey, Krista A. Ryon, Scott M. Smith, Braden T. Tierney, Guy Trudel, Sara R. Zwart, Afshin Beheshti, Christopher E. Mason, Joseph Borg

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)

Abstract It is now widely recognised that the environment in space activates a diverse set of genes involved in regulating fundamental cellular pathways. This includes the activation of genes associated with blood homeostasis and erythropoiesis, with

Externí odkaz: https://doaj.org/article/0b66a7ae76394b36a7d5a9bcfb0634e7

Cosmic kidney disease: an integrated pan-omic, physiological and morphological study into spaceflight-induced renal dysfunction

Autor: Keith Siew, Kevin A. Nestler, Charlotte Nelson, Viola D’Ambrosio, Chutong Zhong, Zhongwang Li, Alessandra Grillo, Elizabeth R. Wan, Vaksha Patel, Eliah Overbey, JangKeun Kim, Sanghee Yun, Michael B. Vaughan, Chris Cheshire, Laura Cubitt, Jessica Broni-Tabi, Maneera Yousef Al-Jaber, Valery Boyko, Cem Meydan, Peter Barker, Shehbeel Arif, Fatemeh Afsari, Noah Allen, Mohammed Al-Maadheed, Selin Altinok, Nourdine Bah, Samuel Border, Amanda L. Brown, Keith Burling, Margareth Cheng-Campbell, Lorianna M. Colón, Lovorka Degoricija, Nichola Figg, Rebecca Finch, Jonathan Foox, Pouya Faridi, Alison French, Samrawit Gebre, Peter Gordon, Nadia Houerbi, Hossein Valipour Kahrood, Frederico C. Kiffer, Aleksandra S. Klosinska, Angela Kubik, Han-Chung Lee, Yinghui Li, Nicholas Lucarelli, Anthony L. Marullo, Irina Matei, Colleen M. McCann, Sayat Mimar, Ahmed Naglah, Jérôme Nicod, Kevin M. O’Shaughnessy, Lorraine Christine De Oliveira, Leah Oswalt, Laura Ioana Patras, San-huei Lai Polo, María Rodríguez-Lopez, Candice Roufosse, Omid Sadeghi-Alavijeh, Rebekah Sanchez-Hodge, Anindya S. Paul, Ralf Bernd Schittenhelm, Annalise Schweickart, Ryan T. Scott, Terry Chin Choy Lim Kam Sian, Willian A. da Silveira, Hubert Slawinski, Daniel Snell, Julio Sosa, Amanda M. Saravia-Butler, Marshall Tabetah, Erwin Tanuwidjaya, Simon Walker-Samuel, Xiaoping Yang, Yasmin, Haijian Zhang, Jasminka Godovac-Zimmermann, Pinaki Sarder, Lauren M. Sanders, Sylvain V. Costes, Robert A. A. Campbell, Fathi Karouia, Vidya Mohamed-Alis, Samuel Rodriques, Steven Lynham, Joel Ricky Steele, Sergio Baranzini, Hossein Fazelinia, Zhongquan Dai, Akira Uruno, Dai Shiba, Masayuki Yamamoto, Eduardo A.C.Almeida, Elizabeth Blaber, Jonathan C. Schisler, Amelia J. Eisch, Masafumi Muratani, Sara R. Zwart, Scott M. Smith, Jonathan M. Galazka, Christopher E. Mason, Afshin Beheshti, Stephen B. Walsh

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)

Abstract Missions into Deep Space are planned this decade. Yet the health consequences of exposure to microgravity and galactic cosmic radiation (GCR) over years-long missions on indispensable visceral organs such as the kidney are largely unexplored

Externí odkaz: https://doaj.org/article/314b862fbe6c4c54a23cb008317e48c9

Immune system dysregulation preceding a case of laboratory-confirmed zoster/dermatitis on board the International Space Station

Autor: Satish K. Mehta, PhD, Rahul Suresh, MD, Keith Brandt, MD, Douglass M. Diak, PhD, Scott M. Smith, PhD, Sara R. Zwart, PhD, Grace Douglas, PhD, Mayra Nelman-Gonzalez, BA, Simon Clemett, PhD, Tyson Brunstetter, OD, PhD, Brian E. Crucian, PhD

Publikováno v: Journal of Allergy and Clinical Immunology: Global, Vol 3, Iss 2, Pp 100244- (2024)

A case report detailing, for the first time, a case of laboratory-confirmed zoster in an astronaut on board the International Space Station is presented. The findings of reduced T-cell function, cytokine imbalance, and increased stress hormones which

Externí odkaz: https://doaj.org/article/96aa0ae9bd194a88a651b2e6b4c4ff88

Impact of diet on human nutrition, immune response, gut microbiome, and cognition in an isolated and confined mission environment

Autor: Grace L. Douglas, Diane DeKerlegand, Holly Dlouhy, Nathan Dumont-Leblond, Eden Fields, Martina Heer, Stephanie Krieger, Satish Mehta, Bridgette V. Rooney, Manolito G. Torralba, Sara E. Whiting, Brian Crucian, Hernan Lorenzi, Scott M. Smith, Millennia Young, Sara R. Zwart

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-22 (2022)

Abstract Long-duration spaceflight impacts human physiology, including well documented immune system dysregulation. The space food system has the potential to serve as a countermeasure to maladaptive physiological changes during spaceflight. However,

Externí odkaz: https://doaj.org/article/753fcbc228d141d9ba576fd8e3bd77a1

Time-resolved molecular measurements reveal changes in astronauts during spaceflight

Autor: Minzhang Zheng, Jacqueline Charvat, Sara R. Zwart, Satish K. Mehta, Brian E. Crucian, Scott M. Smith, Jin He, Carlo Piermarocchi, George I. Mias

Publikováno v: Frontiers in Physiology, Vol 14 (2023)

From the early days of spaceflight to current missions, astronauts continue to be exposed to multiple hazards that affect human health, including low gravity, high radiation, isolation during long-duration missions, a closed environment and distance

Externí odkaz: https://doaj.org/article/501f4065ebfa4965ac8316afab332fac