Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Scott M, Landfear"'
Autor:
Scott M. Landfear
Publikováno v:
Pathogens, Vol 11, Iss 4, p 447 (2022)
Like other kinetoplastid protozoa, the flagellum in Leishmania parasites plays central roles throughout the life cycle. Discoveries over the past decade have begun to elucidate flagellar functions at the molecular level in both the insect vector stag
Externí odkaz:
https://doaj.org/article/a862caf176c44739a2d5775c1f213478
Publikováno v:
mSphere, Vol 3, Iss 4 (2018)
ABSTRACT Glucose transporters are important for viability and infectivity of the disease-causing amastigote stages of Leishmania mexicana. The Δgt1-3 null mutant, in which the 3 clustered glucose transporter genes, GT1, GT2, and GT3, have been delet
Externí odkaz:
https://doaj.org/article/3fe2dc0410634cc6989be263dd42631a
Autor:
Kristin L. Begley, Amy L. Rice, Jean-Claude Dujardin, Jonah Rector, Vivek M. Rangnekar, Corinne M. Fargo, David S. Watt, Yizhe Chen, Diana Ortiz, Liliia M. Kril, Vitaliy M. Sviripa, Ho Shin Kim, Scott M. Landfear, Malgorzata A. Domagalska, Jared T. Hammill, Chunming Liu, R. Kiplin Guy
Publikováno v:
Journal of Medicinal Chemistry
Leishmaniasis, a disease caused by protozoa of the Leishmania species, afflicts roughly 12 million individuals worldwide. Most existing drugs for leishmaniasis are toxic, expensive, difficult to administer, and subject to drug resistance. We report a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb60386e9c3a23c7edf6eb57fe754e45
http://europepmc.org/articles/PMC8404201
http://europepmc.org/articles/PMC8404201
Autor:
Diana Ortiz, W Armand Guiguemde, Jared T Hammill, Angela K Carrillo, Yizhe Chen, Michele Connelly, Kayla Stalheim, Carolyn Elya, Alex Johnson, Jaeki Min, Anang Shelat, David C Smithson, Lei Yang, Fangyi Zhu, R Kiplin Guy, Scott M Landfear
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 12, p e0006157 (2017)
Leishmaniasis is a parasitic infection that afflicts approximately 12 million people worldwide. There are several limitations to the approved drug therapies for leishmaniasis, including moderate to severe toxicity, growing drug resistance, and the ne
Externí odkaz:
https://doaj.org/article/fd582fbd68d94e90b34293f3995c292e
Publikováno v:
Mol Microbiol
Parasites are by definition organisms that utilize resources from a host to support their existence, thus, promoting their ability to establish long-term infections and disease. Hence, sensing and acquiring nutrients for which the parasite and host c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::059c00af0522ac4e91a5a3fa06da84ea
https://doi.org/10.1111/mmi.14635
https://doi.org/10.1111/mmi.14635
Autor:
Felice D. Kelly, Marco A. Sanchez, Kat Schmidt, Scott M. Landfear, Jess Hatfield, Khoa D. Tran
Publikováno v:
Journal of Biological Chemistry. 295:13106-13122
Previous studies in Leishmania mexicana have identified the cytoskeletal protein KHARON as being important for both flagellar trafficking of the glucose transporter GT1 and for successful cytokinesis and survival of infectious amastigote forms inside
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b2c52e1d2b187dd2adab743b136245f
https://doi.org/10.1074/jbc.ra120.014065
https://doi.org/10.1074/jbc.ra120.014065
Autor:
Jess A Millar, Raquel eValdés, Fenil R Kacharia, Scott M Landfear, Eric D. Cambronne, Rahul eRaghavan
Publikováno v:
Frontiers in Microbiology, Vol 6 (2015)
Coxiella burnetii is a bacterium that thrives in an acidic parasitophorous vacuole (PV) derived from lysosomes. Leishmania mexicana, a eukaryote, has also independently evolved to live in a morphologically similar PV. As Coxiella and Leishmania are h
Externí odkaz:
https://doaj.org/article/d8642306c2c5419189b97506f9ac34db
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0134432 (2015)
In a variety of eukaryotes, flagella play important roles both in motility and as sensory organelles that monitor the extracellular environment. In the parasitic protozoan Leishmania mexicana, one glucose transporter isoform, LmxGT1, is targeted sele
Externí odkaz:
https://doaj.org/article/00ce9c711a5742d59c834fb11786f39f
Autor:
Diana Ortiz, W Armand Guiguemde, Alex Johnson, Carolyn Elya, Johanna Anderson, Julie Clark, Michele Connelly, Lei Yang, Jaeki Min, Yuko Sato, R Kiplin Guy, Scott M Landfear
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0123598 (2015)
Development of resistance against current antimalarial drugs necessitates the search for novel drugs that interact with different targets and have distinct mechanisms of action. Malaria parasites depend upon high levels of glucose uptake followed by
Externí odkaz:
https://doaj.org/article/3157b6287d2b423eb876d7995bd2c64e
Autor:
Dan Zilberstein, Scott M. Landfear
Publikováno v:
Trends Parasitol
Kinetoplastid parasites such as trypanosomes and Leishmania must adapt to their environments to survive within their hosts, yet they do not express many of the well-established families of signal transduction receptors. Evidence suggests that other m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc9d783b9a89635580142f06e7272210
https://doi.org/10.1016/j.pt.2018.12.004
https://doi.org/10.1016/j.pt.2018.12.004