Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Scott L. Childs"'
Publikováno v:
CrystEngComm. 16:8984-8993
The objectives of the study were to screen and prepare cocrystals of anti-cholesterol drug ezetimibe (EZT) with the aim of increasing its solubility and dissolution rate. Thermodynamic phase diagra ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0def5906940a3091a20d79ea1bd8a773
https://doi.org/10.1039/c4ce01127a
https://doi.org/10.1039/c4ce01127a
Publikováno v:
Molecular Pharmaceutics. 10:3112-3127
Cocrystals have become an established and adopted approach for creating crystalline solids with improved physical properties, but incorporating cocrystals into enabling pre-clinical formulations suitable for animal dosing has received limited attenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f35c40acd22075db7d9019ad43a23d40
https://doi.org/10.1021/mp400176y
https://doi.org/10.1021/mp400176y
Autor:
Scott L. Childs, Michael J. Zaworotko
Publikováno v:
Crystal Growth & Design. 9:4208-4211
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92427645f2d36d5bb8899755ed55d361
https://doi.org/10.1021/cg901002y
https://doi.org/10.1021/cg901002y
Analysis of 50 Crystal Structures Containing Carbamazepine Using the Materials Module of Mercury CSD
Autor:
L. Sreenivas Reddy, Scott L. Childs, Peter A. Wood, Naír Rodríguez-Hornedo, Kenneth I. Hardcastle
Publikováno v:
Crystal Growth & Design. 9:1869-1888
A set of 50 crystal structures containing the molecule carbamazepine (CBZ) have been analyzed using the Materials module within Mercury CSD 2.0. The similarity relationships between all 50 structures were determined based on the analysis of packing m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee429c802508ef8300a2f097dd2fcd82
https://doi.org/10.1021/cg801056c
https://doi.org/10.1021/cg801056c
Publikováno v:
CrystEngComm. 11:418-426
Mechanochemical liquid-assisted grinding (LAG) and sonochemical (SonicSlurry) techniques have been compared as methods to construct four model pharmaceutical cocrystals involving theophylline and caffeine as pharmaceutical ingredients and L-malic or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c22c9e5479cc6aa57af52bb80887134
https://doi.org/10.1039/b815174a
https://doi.org/10.1039/b815174a
Publikováno v:
Crystal Growth & Design. 7:1291-1304
A crystal engineering method was used to investigate cocrystal formation of piroxicam with pharmaceutically acceptable carboxylic acids. Forming cocrystals of piroxicam can potentially result in solid forms with increased bioavailability. A total of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::712a0e9a62878cd6e22c6380ca7b0b65
https://doi.org/10.1021/cg060742p
https://doi.org/10.1021/cg060742p
Autor:
Simon Bates, Christine Schertz, David Jonaitis, Leonard J. Chyall, Jeanette T. Dunlap, Aeri Park, Rex Shipplett, Scott L. Childs, Barbara C. Stahly
Publikováno v:
Expert Opinion on Drug Discovery. 2:145-154
Modern drug development demands constant deployment of more effective technologies to mitigate the high cost of bringing new drugs to market. In addition to cost savings, new technologies can improve all aspects of pharmaceutical development. New tec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bae33ee842a41c0e81eb1fa000024e0
https://doi.org/10.1517/17460441.2.1.145
https://doi.org/10.1517/17460441.2.1.145
Publikováno v:
Journal of pharmaceutical sciences. 104(12)
This work examines cocrystal solubility in biorelevant media, (FeSSIF, fed state simulated intestinal fluid), and develops a theoretical framework that allows for the simple and quantitative prediction of cocrystal solubilization from drug solubiliza
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13e08cbe7f960d4944858912422e2a4b
https://pubmed.ncbi.nlm.nih.gov/26390213
https://pubmed.ncbi.nlm.nih.gov/26390213
Autor:
Jennifer Giordano, James Cassidy, Aeri Park, Manjunath S. Shet, Edward Patrick O'donnell, Daniel P. McNamara, Anthony Iarriccio, Richard Owen Mannion, Scott L. Childs
Publikováno v:
Pharmaceutical Research. 23:1888-1897
The bioavailability of a development candidate active pharmaceutical ingredient (API) was very low after oral dosing in dogs. In order to improve bioavailability, we sought to increase the dissolution rate of the solid form of the API. When tradition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf66ed019040f96c52bce2dca517f6c5
https://doi.org/10.1007/s11095-006-9032-3
https://doi.org/10.1007/s11095-006-9032-3
Publikováno v:
Crystal Growth & Design. 2:505-510
Crystallization studies of nabumetone (4-(6-methoxy-2-naphthalenyl)-2-butanone) performed in capillary tubes yielded a metastable polymorph. The single-crystal X-ray structure of this high-energy form is presented and compared to the structure of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b069e79d73285afb7e6b19cd2f40c1ab
https://doi.org/10.1021/cg0200311
https://doi.org/10.1021/cg0200311