Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Scott L Kominsky"'
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e66752 (2013)
Bone is the most common site of breast cancer metastasis and once established, it is frequently incurable. Critical to our ability to prevent and treat bone metastasis is the identification of the key factors mediating its establishment and understan
Externí odkaz:
https://doaj.org/article/9b838150f79542efaaebe51e2390d7ee
Autor:
Kristy L Weber, Michele Doucet, Adam Shaner, Nigel Hsu, David Huang, Jenna Fogel, Scott L Kominsky
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40799 (2012)
Pathological bone resorption is a source of significant morbidity in diseases affecting the skeleton such as rheumatoid arthritis, periodontitis, and cancer metastasis to bone. Evidence indicates that elevated levels of inflammatory mediators such as
Externí odkaz:
https://doaj.org/article/4b9673cece6c4b6e9d1bdb8312a1d9ed
Supplementary Fig. S3 from CITED2 Modulates Breast Cancer Metastatic Ability through Effects on IKKα
Effect of IKKα expression on breast cancer patient survival.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2990ab393b9a7384ce2a150fcc2ada70
https://doi.org/10.1158/1541-7786.22510821
https://doi.org/10.1158/1541-7786.22510821
cDNA microarray analysis of gene expression between shscramble and shCITED2-expressing MDA-MB-231 cells. Supplementary Fig. S1: Effect of CITED2 knockdown on metastasis to non-bone sites. Supplementary Fig. S2: Regulation of OPN, MMP9, uPA, SPARC, IL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::004d706e0d2133295757c169b6e8936d
https://doi.org/10.1158/1541-7786.22510818
https://doi.org/10.1158/1541-7786.22510818
Approximately 30% of patients with renal cell carcinoma (RCC) develop bone metastasis, which is characterized by extensive osteolysis leading to severe bone pain and pathologic fracture. Although the mechanism of RCC-induced osteolysis is unknown, st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ff904c372d52519e9d2f118f73c552c
https://doi.org/10.1158/0008-5472.c.6497366
https://doi.org/10.1158/0008-5472.c.6497366
Supplementary Figure 1 Legend from Macrophage Inflammatory Protein–1δ: A Novel Osteoclast Stimulating Factor Secreted by Renal Cell Carcinoma Bone Metastasis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ddc009871d5ed43e4ca8324b7430512
https://doi.org/10.1158/0008-5472.22374227
https://doi.org/10.1158/0008-5472.22374227
Supplementary Figure 1 from Macrophage Inflammatory Protein–1δ: A Novel Osteoclast Stimulating Factor Secreted by Renal Cell Carcinoma Bone Metastasis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1311b87c713e6b3165b825b9f757d92d
https://doi.org/10.1158/0008-5472.22374224
https://doi.org/10.1158/0008-5472.22374224
Autor:
Kristy L. Weber, Brittany Tusing, Michele Doucet, Swaathi Jayaraman, Scott L. Kominsky, Emily Swenson
Publikováno v:
Journal of Bone and Mineral Research. 31:1381-1390
CCL20 is a member of the macrophage inflammatory protein family and is reported to signal monogamously through the receptor CCR6. Although studies have identified the genomic locations of both Ccl20 and Ccr6 as regions important for bone quality, the
Publikováno v:
Oncology Letters
The transcriptional co-regulator Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain-2 (CITED2) may promote breast tumor growth; however, the mechanisms by which its effects are mediated remain to be fully elucidated. Tumor-
Autor:
David L. Huso, Saraswati Sukumar, Nguyen Nguyen, Lionel Feigenbaum, Pedram Argani, Manfred Gessler, Göran Landberg, Soonweng Cho, Scott L. Kominsky, Preethi Korangath, Wei Wen Teo, Adam Diehl, Liangfeng Han, Alan Rein
Publikováno v:
Cancer Research. 74:6509-6518
Acquired resistance to TGFβ is a key step in the early stages of tumorigenesis. Mutations in TGFβ signaling components are rare, and little is known about the development of resistance in breast cancer. On the other hand, an activated Notch pathway