Zobrazeno 1 - 10
of 306
pro vyhledávání: '"Scott L Diamond"'
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 1, p e1009850 (2022)
Modeling thrombus growth in pathological flows allows evaluation of risk under patient-specific pharmacological, hematological, and hemodynamical conditions. We have developed a 3D multiscale framework for the prediction of thrombus growth under flow
Externí odkaz:
https://doaj.org/article/b1124ba7ec364a959c468b28f2fd5f05
Publikováno v:
PLoS ONE, Vol 17, Iss 1, p e0262523 (2022)
Risk quantification algorithms in the ICU can provide (1) an early alert to the clinician that a patient is at extreme risk and (2) help manage limited resources efficiently or remotely. With electronic health records, large data sets allow the train
Externí odkaz:
https://doaj.org/article/f95d72ffcbfc47d69a62f24b01996bbf
Autor:
Jason Chen, Scott L Diamond
Publikováno v:
PLoS ONE, Vol 16, Iss 11, p e0260366 (2021)
A highly reduced extrinsic pathway coagulation model (8 ODEs) under flow considered a thin 15-micron platelet layer where transport limitations were largely negligible (except for fibrinogen) and where cofactors (FVIIa, FV, FVIII) were not rate-limit
Externí odkaz:
https://doaj.org/article/24a5a9b68f8e492d9294362b4a83f107
Publikováno v:
PLoS ONE, Vol 15, Iss 11, p e0242166 (2020)
A 400-estimator gradient boosting classifier was trained to predict survival probabilities of trauma patients. The National Trauma Data Bank (NTDB) provided 799233 complete patient records (778303 survivors and 20930 deaths) each containing 32 featur
Externí odkaz:
https://doaj.org/article/5123d911671f4947a28ec7bc5f072d6c
Autor:
Jason Chen, Scott L Diamond
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 8, p e1007266 (2019)
During thrombosis, thrombin generates fibrin, however fibrin reversibly binds thrombin with low affinity E-domain sites (KD = 2.8 μM) and high affinity γ'-fibrin sites (KD = 0.1 μM). For blood clotting on collagen/tissue factor (1 TF-molecule/μm2
Externí odkaz:
https://doaj.org/article/2ef6f5bd52eb41f9b49e72075d936e28
Autor:
Mei Yan Lee, Scott L Diamond
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 2, p e1004118 (2015)
Since platelet intracellular calcium mobilization [Ca(t)]i controls granule release, cyclooxygenase-1 and integrin activation, and phosphatidylserine exposure, blood clotting simulations require prediction of platelet [Ca(t)]i in response to combinat
Externí odkaz:
https://doaj.org/article/81e41c9bf1d34167a62984c3286146d8
Autor:
Catherine Moorwood, Olga Lozynska, Neha Suri, Andrew D Napper, Scott L Diamond, Tejvir S Khurana
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26169 (2011)
Duchenne muscular dystrophy (DMD) is a devastating muscle wasting disease caused by mutations in dystrophin, a muscle cytoskeletal protein. Utrophin is a homologue of dystrophin that can functionally compensate for its absence when expressed at incre
Externí odkaz:
https://doaj.org/article/3195a3450c9d4923b6df78d8c63f87ee
Publikováno v:
PLoS Computational Biology, Vol 6, Iss 9, p e1000950 (2010)
Blood function defines bleeding and clotting risks and dictates approaches for clinical intervention. Independent of adding exogenous tissue factor (TF), human blood treated in vitro with corn trypsin inhibitor (CTI, to block Factor XIIa) will genera
Externí odkaz:
https://doaj.org/article/2a94d3607e894bf3a92efad6aef3af8b
Autor:
Justin D Clifton, Edinson Lucumi, Michael C Myers, Andrew Napper, Kotaro Hama, Steven A Farber, Amos B Smith, Donna M Huryn, Scott L Diamond, Michael Pack
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e12386 (2010)
Pharmacological inhibition of dietary lipid absorption induces favorable changes in serum lipoprotein levels in patients that are at risk for cardiovascular disease and is considered an adjuvant or alternative treatment with HMG-CoA reductase inhibit
Externí odkaz:
https://doaj.org/article/241017dc0ee8441b831de9a65c6e0e9d
Publikováno v:
PLoS Computational Biology, Vol 5, Iss 3, p e1000298 (2009)
A defining characteristic of living cells is the ability to respond dynamically to external stimuli while maintaining homeostasis under resting conditions. Capturing both of these features in a single kinetic model is difficult because the model must
Externí odkaz:
https://doaj.org/article/728e13fac510443a95fa4237ae9d9cd4