Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Scott L, Lipnick"'
Autor:
Brett K. Beaulieu-Jones, Francesca Frau, Sylvie Bozzi, Karen J. Chandross, M. Judith Peterschmitt, Caroline Cohen, Catherine Coulovrat, Dinesh Kumar, Mark J. Kruger, Scott L. Lipnick, Lane Fitzsimmons, Isaac S. Kohane, Clemens R. Scherzer
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-11 (2024)
Abstract Characterization of Parkinson’s disease (PD) progression using real-world evidence could guide clinical trial design and identify subpopulations. Efforts to curate research populations, the increasing availability of real-world data, and a
Externí odkaz:
https://doaj.org/article/5b1ab7fff87c4cc3824c3db7cf2721f4
Autor:
William Yuan, Brett Beaulieu-Jones, Richard Krolewski, Nathan Palmer, Christine Veyrat-Follet, Francesca Frau, Caroline Cohen, Sylvie Bozzi, Meaghan Cogswell, Dinesh Kumar, Catherine Coulouvrat, Bruno Leroy, Tanya Z. Fischer, S. Pablo Sardi, Karen J. Chandross, Lee L. Rubin, Anne-Marie Wills, Isaac Kohane, Scott L. Lipnick
Publikováno v:
BMC Neurology, Vol 21, Iss 1, Pp 1-12 (2021)
Abstract Background Characterization of prediagnostic Parkinson’s Disease (PD) and early prediction of subsequent development are critical for preventive interventions, risk stratification and understanding of disease pathology. This study aims to
Externí odkaz:
https://doaj.org/article/9e6364d125584b15943a54481769b978
Autor:
William Yuan, Brett K. Beaulieu-Jones, Kun-Hsing Yu, Scott L. Lipnick, Nathan Palmer, Joseph Loscalzo, Tianxi Cai, Isaac S. Kohane
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
One of the primary tools that researchers use to predict risk is the case-control study. Here, the authors identify a flaw, temporal bias, that is specific to and uniquely associated with these studies that occurs when the study period is not represe
Externí odkaz:
https://doaj.org/article/f09efdb3737c425a8e69b209f85bbec0
Autor:
Methodios Ximerakis, Kristina M. Holton, Richard M. Giadone, Ceren Ozek, Monika Saxena, Samara Santiago, Xian Adiconis, Danielle Dionne, Lan Nguyen, Kavya M. Shah, Jill M. Goldstein, Caterina Gasperini, Ioannis A. Gampierakis, Scott L. Lipnick, Sean K. Simmons, Sean M. Buchanan, Amy J. Wagers, Aviv Regev, Joshua Z. Levin, Lee L. Rubin
Publikováno v:
Nature Aging. 3:327-345
Aging is a complex process involving transcriptomic changes associated with deterioration across multiple tissues and organs, including the brain. Recent studies using heterochronic parabiosis have shown that various aspects of aging-associated decli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8657f8805441eff3eb51264f9415b9f0
https://doi.org/10.1038/s43587-023-00373-6
https://doi.org/10.1038/s43587-023-00373-6
Autor:
Scott L Lipnick, Denis M Agniel, Rahul Aggarwal, Nina R Makhortova, Samuel G Finlayson, Alexandra Brocato, Nathan Palmer, Basil T Darras, Isaac Kohane, Lee L Rubin
Publikováno v:
PLoS ONE, Vol 14, Iss 3, p e0213680 (2019)
ObjectiveWe investigated the presence of non-neuromuscular phenotypes in patients affected by Spinal Muscular Atrophy (SMA), a disorder caused by a mutation in the Survival of Motor Neuron (SMN) gene, and whether these phenotypes may be clinically de
Externí odkaz:
https://doaj.org/article/f91043b306394e359bbb84cc9e3bcf10
Autor:
Methodios Ximerakis, Kristina M. Holton, Richard M. Giadone, Ceren Ozek, Monika Saxena, Samara Santiago, Xian Adiconis, Danielle Dionne, Lan Nguyen, Kavya M. Shah, Jill M. Goldstein, Caterina Gasperini, Scott L. Lipnick, Sean K. Simmons, Sean M. Buchanan, Amy J. Wagers, Aviv Regev, Joshua Z. Levin, Lee L. Rubin
Aging is a complex process involving transcriptomic changes associated with deterioration across multiple tissues and organs, including the brain. Recent studies using heterochronic parabiosis have shown that various aspects of aging-associated decli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::faa15dde94ef8da6cad65bafb306b3bd
https://doi.org/10.1101/2022.01.27.477911
https://doi.org/10.1101/2022.01.27.477911
Autor:
Samuel G, Finlayson, Matthew B A, McDermott, Alex V, Pickering, Scott L, Lipnick, Isaac S, Kohane
Publikováno v:
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing
Modeling the relationship between chemical structure and molecular activity is a key goal in drug development. Many benchmark tasks have been proposed for molecular property prediction, but these tasks are generally aimed at specific, isolated biomed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::25faa9cfd511a4f6d25b0a2b1039418e
https://pubmed.ncbi.nlm.nih.gov/33691024
https://pubmed.ncbi.nlm.nih.gov/33691024
Autor:
Methodios, Ximerakis, Scott L, Lipnick, Brendan T, Innes, Sean K, Simmons, Xian, Adiconis, Danielle, Dionne, Brittany A, Mayweather, Lan, Nguyen, Zachary, Niziolek, Ceren, Ozek, Vincent L, Butty, Ruth, Isserlin, Sean M, Buchanan, Stuart S, Levine, Aviv, Regev, Gary D, Bader, Joshua Z, Levin, Lee L, Rubin
Publikováno v:
Nature neuroscience. 22(10)
The mammalian brain is complex, with multiple cell types performing a variety of diverse functions, but exactly how each cell type is affected in aging remains largely unknown. Here we performed a single-cell transcriptomic analysis of young and old
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::da0e860102d58e106c1aae6eb44ab5f2
https://pubmed.ncbi.nlm.nih.gov/31551601
https://pubmed.ncbi.nlm.nih.gov/31551601
The Very Large Array has been used at five frequencies to study the structure and linear polarization of SS433 on scales as small as ~0.1" ~ 500 AU. Each jet consists of a sharp, curving ridge-line at the leading edge, plus significant trailing off-j
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5f7b4bb2a2397739042fc11d4bb1621
http://arxiv.org/abs/0712.2005
http://arxiv.org/abs/0712.2005