Výsledky vyhledávání - "Scott L, Kincaid"

Combinatorial synthesis of substituted 3-(2-indolyl)piperidines and 2-phenyl indoles as inhibitors of ZipA–FtsZ interaction

Autor: Lee D, Jennings, Kenneth W, Foreman, Thomas S, Rush, Desiree H H, Tsao, Lidia, Mosyak, Scott L, Kincaid, Mohani N, Sukhdeo, Alan G, Sutherland, Weidong, Ding, Cynthia Hess, Kenny, Chantel L, Sabus, Hanlan, Liu, Elizabeth G, Dushin, Soraya L, Moghazeh, Pornpen, Labthavikul, Peter J, Petersen, Margareta, Tuckman, Steven A, Haney, Alexey V, Ruzin

Publikováno v: Bioorganic & Medicinal Chemistry. 12:5115-5131

The ZipA–FtsZ protein–protein interaction is a potential target for antibacterial therapy. The design and parallel synthesis of a combinatorial library of small molecules, which target the FtsZ binding area on ZipA are described. Compounds were d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41000540d428bfc3965e4aaf6d9608f0
https://doi.org/10.1016/j.bmc.2004.07.031

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Parallel synthesis and biological evaluation of 5,6,7,8-tetrahydrobenzothieno[2,3-d]pyrimidin-4(3H)-one cytotoxic agents selective for p21-deficient cells

Autor: Yanong D. Wang, Carl F. Beyer, Carolyn Discafani, Lee D. Jennings, Scott L. Kincaid, Girija Krishnamurthy, Sridhar K. Rabindran, John P. McGinnis, Miriam Miranda

Publikováno v: Bioorganicmedicinal chemistry letters. 15(21)

A novel series of inhibitors of cancer cell proliferation, selective against p21 cell cycle checkpoint-disrupted cells vs. cells with intact p21 checkpoint, were identified by high-throughput screening. Optimization of both ends of the lead molecule

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d2555d795fe1237613225f6a11922de
https://pubmed.ncbi.nlm.nih.gov/16143523

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Corrigendum to 'Combinatorial synthesis of substituted 3-(2-indolyl)piperidines and 2-phenyl indoles as inhibitors of ZipA–FtsZ interaction' [Bioorg. Med. Chem. 12 (2004) 5115–5131]

Autor: Steven A. Haney, Soraya L. Moghazeh, Thomas S. Rush, Pornpen Labthavikul, Margareta Tuckman, Peter Petersen, Lidia Mosyak, Lee D. Jennings, Mohani N. Sukhdeo, Weidong Ding, Alexey Ruzin, Hanlan Liu, Desiree H.H. Tsao, Scott L. Kincaid, Alan G. Sutherland, Cynthia Hess Kenny, Elizabeth G. Dushin, Chantel L. Sabus, Kenneth Foreman

Publikováno v: Bioorganic & Medicinal Chemistry. 13:5884

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::735e3bfe326d14a302214b1a9f4f55e5
https://doi.org/10.1016/j.bmc.2005.08.001

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